Catalytic Synthesis and Characterization of Biodegradable ...

Chapter 1
parameters. Moreover, the morphology of the composites will also be changed with different
PPy content (Figure 1.5.7). The fibroblasts exhibited improved attaching and growth on the
PPy nanoparticle-PLA composites membranes under the simulated of current compared to
that cultured without simulation. The composites provided a new way to design electroactive,
biocompatible and biodegradable materials with simple blending approach.
Figure 1.5.7 SEM images of the surface of PPy nanoparticle-PLA composite membranes with
various PPy content: (A) 5%, (B) 7%, (C) 9%, and (D) 17%. 117
Many cells, especially nerve cell, have filaceous parts which will exhibit different
topography. And the topography of culture substrate will influence the growth and
differentiation of these cells. Some studies have explored the effect of surface topography of
electroactive materials on cell culture. For instance, patterning of 1 and 2 μm wide PPyPSS
microchannels can be fabricated using electron beam lithography. 131 Then the embryonic
hippocampal neurons were seeded on this matrix and found to polarize (i.e., define an axon)
faster, exhibiting a two-fold increase in the number of cells with axons compared to cells
cultured on unmodified PPyPSS (Figure 1.5.8). For instance, patterning of 1 and 2 μm wide
PPyPSS microchannels can be fabricated using electron beam lithography. 131 Then the
embryonic hippocampal neurons were seeded on this matrix and found to polarize (i.e., define
an axon) faster, exhibiting a two-fold increase in the number of cells with axons compared to
cells cultured on unmodified PPyPSS (Figure 1.5.8).
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