Catalytic Synthesis and Characterization of Biodegradable ...

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Chapter 1 synthesized hyaluronic acid (HA)-doped PPy and explored its tissue engineering applications. 129 In vivo studies showed that the introducing of HA into PPy films improved the biocompatibility of PPy and promoted the vascularization. It should be noted that both conductivity and the film surface are often greatly changed when biologically active molecules are used as dopants. 129, 130 For example, the morphology and conductivity of polypyrrole-based films with different dopants were systematically studied. It was concluded that larger biomolecule dopants can significantly decrease conductivity and affect more obviously on morphology compared to small dopants. However, the exact effects of particular dopants are not very predictable (Figure 1.5.5). Figure 1.5.5 Morphology of thick PPy films as assessed using scanning electron microscopy (SEM) (top) and corresponding cyclic voltammograms (CVs), indicating electrical activity of the materials (bottom). (A) PPyCl. (B) PPy doped with poly(vinyl sulfate). (C) PPy doped with dermatan sulfate. (D) PPy doped with collagen (inset: thin film of collagen-doped PPy). A narrow ‐ 24 ‐
- 25 - Polymerization and Applications of Biodegradable Polyesters CV spectrum correlates to decreased electroactivity. Scale bars are 100 μm. 130 PPy can not be further covalently modified due to there are no functional pendent or terminal groups on its chain. This limitation can be overcome by doping with polymers having functional groups. A good example of this technique is conducted by Song et al. In their report, PPy was doped with poly(glutamic acid) (PGlu), which has pendent carboxylic acid groups could further react with amino of polylysine and/or laminin. Dorsal root ganglion (DRG) neurons were observed to preferentially adhere to and extend neurites on the PPy surfaces modified with polylysine and/or laminin (Figure 1.5.6). 130 Figure 1.5.6 Phase contrast and fluorescence images of DRGs adhered to the surface of pPy-X, where X = 1. pLys, 2. Lmn, and 3. pLys-Lmn. Cell nuclei were labeled with DAPI (blue florescence). All images were taken at 10× magnification and the 200 μm scale bar applies to all images shown. 130 PPy is not biodegradable in nature and many works were carried out to blend it with biodegradable polymeric materials to obtain partially absorbable materials. For example, PPy nanoparticle was blended with PLA to fabricate a composite which is both biodegradable and conductive. 117 Altering the content of PPy in the composites will result in the changes of both
Page 1 and 2: Catalytic Synthesis and Characteriz
Page 3 and 4: Preface Biodegradable polyesters ha
Page 5 and 6: Chapter 3 Polymerization of Lactic
Page 7 and 8: Chapter 1 Polymerization and Applic
Page 9 and 10: - 3 - Polymerization and Applicatio
Page 13 and 14: 1.2.2 Aluminum Catalysts - 7 - Poly
Page 17 and 18: 1.3 Polylactide 1.3.1 Introduction
Page 19 and 20: - 13 - Polymerization and Applicati
Page 21 and 22: 1.3.4 Application of PLA Figure 1.3
Page 27 and 28: 1.5.1.4 Polyaniline (PANi) - 21 - P
Page 29: - 23 - Polymerization and Applicati
Page 47 and 48: 1.6.1 Radical Polymers for Organic
Page 51 and 52: initialization of the device by app
Page 55 and 56: 1.6.2.4 Others - 49 - Polymerizatio
Page 63 and 64: 182. R. B. Weller, J. Invest. Derma
Page 65 and 66: Chapter 2 Synthesis and Electrochem
Page 67 and 68: Synthesis and Electrochemistry of S
Page 79: Synthesis and Electrochemistry of S
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Chapter 3 3.1 Introduction Poly(lac
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Chapter 3 polydispersity index (PDI
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Chapter 3 aluminum based complexes
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Chapter 3 3.5 Conclusions Co(III) c
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Chapter 3 22. Z. H. Tang, X. S. Che
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Chapter 4 4.1 Introduction Stimulus
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Chapter 4 the proton of methenyl gr
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Chapter 4 attributed to the amide g
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Chapter 4 4.4 Thermal Properties Th
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Chapter 4 Figure 4.8 MTT assay for
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Chapter 4 The 1 H NMR and 13 C NMR
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Chapter 4 Cell viability (%) = (Asa
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Chapter 5 Synthesis of Triblock Cop
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5.2 Synthesis of Triblock Copolymer
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Sample Table 1. Feed and result com
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= 25 μm. B: MTT assay for the cyto
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‐ 109 ‐ Synthesis of Triblock C
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‐ 111 ‐ Synthesis of Triblock C
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Chapter 6 6.1 Introduction Since th
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Chapter 6 6.3 Synthesis of MPEG-b-P
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Chapter 6 used to characterize the
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Chapter 6 Figure 6.6 Cyclic voltamm
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Chapter 6 vivo cytotoxicity was als
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Chapter 6 NMR. Characterization of
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Chapter 6 CO2 for 24 h. RSC96 cells
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Chapter 7 Conclusion and Future Pro
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‐ 131 ‐ Conclusion and Future P
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‐ 133 ‐ Conclusion and Future P
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13. Xuan Pang, Xuesi Chen, Xiuli Zh
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Acknowledgments The present thesis
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