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the united republic of tanzania health sector hiv and aids strategic plan

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C). HIV, STI <strong>and</strong> TB drugs resistance <strong>and</strong> drug side effects<br />

Situation analysis<br />

As <strong>the</strong> HIV <strong>and</strong> AIDS programmes are scaled up, <strong>the</strong>re is a risk <strong>of</strong> emergence <strong>of</strong> HIV drug resistance. This<br />

risk needs to be identified early so that appropriate measures are instituted.<br />

It must be borne in mind that before <strong>the</strong> start <strong>of</strong> <strong>the</strong> CTC, already <strong>the</strong>re were clients on ARVs. These had<br />

used <strong>the</strong> ARVs without <strong>the</strong> benefit <strong>of</strong> any guidelines! Therefore, <strong>the</strong>re is a fear <strong>of</strong> having a pool <strong>of</strong> people<br />

with resistant organisms.<br />

There is need to monitor STI <strong>and</strong> TB drug susceptibility patterns to inform policies on management <strong>of</strong> STIs<br />

<strong>and</strong> possible emergence <strong>of</strong> multi-resistant TB.<br />

Achievements<br />

There are internationally validated indicators for early identification <strong>of</strong> HIV drug resistance which<br />

<strong>the</strong> country has adopted.<br />

Tanzania has initiated <strong>and</strong> implemented surveillance <strong>of</strong> HIV drug resistance in one region.<br />

Activities on HIV drug resistance monitoring have been initiated<br />

Availability <strong>of</strong> pharmacovigilance system for all pharmaceutical products<br />

Challenges<br />

Challenges<br />

Availability • Surveillance activities on <strong>the</strong> epidemic concerning drugs resistance monitoring<br />

(for STI <strong>and</strong> ARV) are inadequate.<br />

• There is no sufficient capacity to carry out STI drug susceptibility monitoring<br />

• Insufficient capacity to correctly identify <strong>and</strong> report on side effects <strong>of</strong> HIV drugs<br />

Quality • The staff in <strong>health</strong> facilities have not been empowered to carry out<br />

pharmacovigilance activities for ARVs<br />

Equity, Gender <strong>and</strong> sustainability considerations<br />

The cost involved in conducting regular surveillance activities <strong>and</strong> coverage <strong>of</strong> all facilities especially in<br />

rural areas is big.<br />

Strategic objective<br />

To streng<strong>the</strong>n <strong>and</strong> sustain HIV drug resistance activities, STI drug resistance monitoring <strong>and</strong><br />

pharmacovigilance <strong>of</strong> HIV drugs<br />

Strategies<br />

Conduct STI drug <strong>and</strong> TB drug susceptibility monitoring<br />

Carry out HIV Drug resistance prevention activities,<br />

HIV Drug resistance surveillance <strong>and</strong> monitoring<br />

Streng<strong>the</strong>n a mechanism for tracking <strong>and</strong> providing feedback on ADR associated with HIV <strong>and</strong><br />

AIDS, STI <strong>and</strong> OIs medication.<br />

Train <strong>health</strong> personnel on ARV adverse drug reactions (ADR)<br />

Targets<br />

4 Zonal laboratories to perform STI drug resistance testing<br />

1 special hospital <strong>and</strong> 1 referral hospital perform TB drug resistance testing<br />

HIV drug resistance monitoring activities to be done in all <strong>health</strong> facilities providing ART<br />

services<br />

HIV drug resistance surveillance testing in 1 HIV Reference lab<br />

Indicators<br />

Number <strong>of</strong> STI susceptibility monitoring done<br />

Number <strong>of</strong> HIV drug surveillance,<br />

Number <strong>of</strong> monitoring <strong>and</strong> reports <strong>of</strong> ADRs<br />

58 |FINAL COMBINED-HSHSP 2008-2012: June 24 th 2007

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