2008 Annual Report - Chemical and Biomolecular Engineering ...

L. James Lee
Professor, Ph.D., University
of Minnesota, 1979. Polymer
and Composite Engineering,
Nanobiotechnology, BioMEMS,
Microfluidics, BioMEMS/NEMS.
Malcolm E. Pruitt Award, Council of
Chemical Research
Engineering/Technology Award, Society of Plastics Engineers
Books and Book Chapters
Guan, J., He, H., Yu, B., Lee, L.J., “Polymeric Nanostructures
for Controlled Drug and Gene Delivery” in Biomedical
Nanostructures, Edited by K.E. Gonsalves, C.T. Laurencin, C.
Halberstadt and L.S. Nair, John Wiley & Sons, Inc., pp. 115-
137, 2008.
Guan, J., Pan, X., Lee, L.J. and Lee, R.J., “Therapeutic
Gene Delivery” in Biopharmaceutical Drug Design and
Development, Edited by S. Wu-Pong and Y. Rojanasakul,
Humana Press, Ch. 8, 2008.
Refereed Papers
X. Pan, J. Guan, J-W Yoo, A.J. Epstein, L.J. Lee and R.J. Lee,
“Cationic Lipid Coated Magnetic Nanoparticles Associated
with Transferrin for Gene Delivery,” International Journal of
Pharmaceutics, 358, 263-270 (2008).
P. Pradhan, J. Guan, D. Lu, P. G. Wang, L.J. Lee and R.J. Lee,
“A Facile Microfluidic Method for Production of Liposomes,”
Anticancer Research, 28, 943-948 (2008).
R. Lapalombella, X. Zhao, G. Triantafillou, B. Yu, Y. Lin,
G. Lozanski, C. Cheney, N. Heerema, D. Jarjoura, A.
Lehman, L.J. Lee, R. Lee , M.A. Caligiuri, N. Muthusamy
and J.C. Byrd, “A Novel Raji-Burkitt’s Lymphoma Model for
Preclinical and Mechanistic Evaluation of CD52-Targeted
Immunotherapeutic Agents,” Clinical Cancer Research, 14,
569-578 (2008).
N-R. Chiou, L.J. Lee, A.J. Epstein, “Porous Membrane
Controlled Polymerization of Nanofibers of Polyaniline and
Its Derivatives,” Journal of Materials Chemistry, 18, 2085-
2089 (2008).
S. Wang, J. Guan and L.J. Lee, “Flow Guided Dynamic
Assembly,” ChemPhysChem, 9, 967-973 (2008).
S. Wang, X. Hu and L.J. Lee “Electrokinetics Induced
Asymmetric Transport in Polymeric Nanonozzles,” Lab on a
Chip, 8, 573-581 (2008).
K. Park, J. Jang, D. Irimia, J. Sturgis, L.J. Lee, P. Robinson,
M. Toner and R. Bashir, “Living Cantilever Arrays for
Characterization of Mass of Single Live Cells in Fluids,” Lab
on a Chip, 8, 1034-1041 (2008).
G. Zhou, L.J. Lee and J. Castro, “Nanoclay and Long Fiber
Reinforced Composites based on Epoxy and Phenolic Resins,”
Journal of Applied Polymer Science, 108 (6), 3720-3726
(2008).
Z. Guo, J. Yang, M.E. Berg, M.J. Wingert, D.L. Tomasko,
L.J. Lee and T. Daniel, “Comparison of Carbon Nanofibers
and Activated Carbon on Carbon Dioxide Foaming of
Polystyrene,” Journal of Cellular Plastics, 44, 453-468 (2008).
H. Chen, M-L Cheng, Y.C. Jean, L.J. Lee and J. Yang, “Effect
of CO2 Exposure on Free Volumes in Polystyrene Studied
by Positron Annihilation Spectroscopy,” Journal of Polymer
Science, Part B: Polymer Physics, 46, 388-405 (2008).
L-T Huang, P-S Hsu, S.C. Chen, J-Y Lai and L.J. Lee, “PTFE
Paste Extrusion and Membrane Pore Size Control,” Advances
in Polymer Technology, 26(3), 163-172 (2008).
X. Zhang, H. He and L.J. Lee, “A Biodegradable,
Immunoprotective, Dual Nanoporous Capsule for Cell-Based
Therapies,” Biomaterials, published on-line (2008).
X. Yang, C.G. Koh, S. Liu, X. Pan, R. Santhanam, B. Yu, Y.
Peng, J. Pang, S. Golan, Y. Talmon, Y. Jin, N. Muthusamy,
J.C. Byrd, K.K. Chan, L.J. Lee, G. Marcucci and R.J. Lee,
“Transferrin Receptor-Targeted Lipid Nanoparticles for
Delivery of an Antisense Oligodeoxyribonucleotide against
Bcl-2,” Molecular Pharmaceutics, published on-line (2008).
S. Movva, G. Zhou, D. Guerra, and L.J. Lee, “Effect of Carbon
Nanofibers on Mold Filling in a Vacuum Assisted Resin
Transfer Molding System,” J. Composite Materials, 42 (24)
(2008).
Y. Yuan, H. He, and L.J. Lee, “Protein A-based Immobilization
of Antibody onto A Polymeric Microfluidic Device for
Enzyme-linked Immunosorbent Assay,” Bioengineering and
Biotechnology, 102(3), 891-901 (2009).
Patents
J. Guan, L.J. Lee and D. Hansford, “Fabrication of Polymeric
Micro-Devices for Drug Delivery by Surface Patterning and
Self-Folding,” U.S. Patent 7,364,675, April 29, 2008.
L J. Lee, S. Wang, Y. Xie, C. Zeng, C-G Koh and Z. Fei, “Drug
and Gene Delivery by Polymer Nanonozzle and Nanotip Cell
Patch for ,” Invention disclosed, PCT Publication No. WO
2007/053802 A2, published on May 10, 2007, U.S. Patent
Application No. 2008/0248575 A1 filed on Oct. 9, 2008.
N-R Chiou, L.J. Lee, J. Yang and S-K Yeh, “Surfactant-
Free Synthesis and Foaming of Liquid Blowing Agent-
Containing Activated Carbon Nano/Microparticulate
Polymer Composites,” U.S. Provisional Patent Application No.
61/130,061 filed on May 28, 2008.
Current Projects and Grants
$12,900,000 - Lee, L. James (PI) 2004-2009 Nanoscale Science
and Engineering Center for Affordable Nanoengineering of
Polymer Biomedical Devices, National Science Foundation.
$22,489,845 - Lee, L. James (PI) 2005-2008 Center for
Multifunctional Polymer Nanomaterials and Devices, Ohio
Department of Development Third Frontier Program.
$360,000 - Lee, L. James (co-PI) 2006-2008 Evaluating the
Impacts of Nanomanufacturing via Thermodynamic and Life
Cycle Analysis, EPA.
29