Application Compendium - Agilent Technologies
Application Compendium - Agilent Technologies
Application Compendium - Agilent Technologies
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Authors<br />
Melissa Dunkle, Gerd Vanhoenacker,<br />
Frank David, Pat Sandra<br />
Research Institute for Chromatography,<br />
President Kennedypark 26,<br />
8500 Kortrijk, Belgium<br />
Martin Vollmer<br />
<strong>Agilent</strong> <strong>Technologies</strong>, Inc.<br />
Waldbronn, Germany<br />
Determination of phthalate<br />
migration from toys<br />
Using the <strong>Agilent</strong> 1260 Infi nity Analytical SFC System<br />
with an <strong>Agilent</strong> 6130 Single Quadrupole LC/MS<br />
<strong>Application</strong> Note<br />
Consumer Products<br />
90000<br />
80000<br />
70000<br />
60000<br />
50000<br />
40000<br />
30000<br />
20000<br />
10000<br />
0<br />
Abstract<br />
DBP<br />
DEHP<br />
DiNP, DiDP<br />
BBzP<br />
2 4 6 8 10 12 14 min<br />
Supercritical fl uid chromatography (SFC) can be used for the determination of<br />
polymer additives such as phthalates that can migrate or leach out of plastics.<br />
In this <strong>Application</strong> Note, the analysis of phthalates in a migration test from<br />
PVC toys is performed using the <strong>Agilent</strong> 1260 Infi nity Analytical SFC System<br />
in combination with an <strong>Agilent</strong> 6130 Single Quadrupole LC/MS. The SFC/MS<br />
approach facilitated identifi cation and quantifi cation of mixed isomer<br />
phthalates in less than 15 minutes analysis time with good repeatability.