Course Syllabus - North Carolina State University College of ...

Course Syllabus
Fundamentals of Biomedical Sciences
CBS565
Fall, 2012 (updated 7 Aug 2012)
Course Director: Jeffrey A Yoder, Ph.D.; (919) 515-7406; jeff_yoder@ncsu.edu
Note: this syllabus is subject to change, particularly in the lecture topics. Students will be notified in
class of any changes.
Textbook: there is no required textbook for this course, but suggested reference materials include
� Textbook of Veterinary Physiologcial Chemistry (updated Second edition), Larry
R. Engelking. 2010. ISBN-10: 0123848520 | ISBN-13: 978-0123848529
� Molecular Biology of the Cell, 5 th Edition Alberts et al., ISBN = 978-0-8153-
4105-5 or 978-0-8153-4106-2.
� Anatomy and Physiology, 3 rd Edition. Marieb and Hoehn (eds.) 2007. ISBN =
978-0805347739.
� Pathologic Basis of Veterinary Disease, 4 th Edition. McGavin and Zachary
(eds.) 2007. ISBN = 0-3230-2870-5.
� Comparative Pharmacokinetics: Principles, Techniques & Applications, -
Riviere, 2003 (or 1999), ISBN = 0-8138-2931-3
� Veterinary Pharmacology and Therapeutics, 8 th Edition. Adams (Ed). 2001,
ISBN = 978-0813817439
� Veterinary Pharmacology and Therapeutics, 9 th Edition. Riviere and Papichs
(Eds). 2009
� Rodent Necropsy Procedures
These texts will be on “reserve” at the circulation desk of the CVM library
throughout the semester.
Handouts: Handouts will be provided as hardcopies in class or on-line as pdfs.
Course Web-Page: A course web page (NCSU Learning Management System) will be maintained
throughout the semester and will include pdf versions of the syllabus, course schedule, handouts and
lecture notes (when available). The web-page can be accessed at http://moodle.wolfware.ncsu.edu/
Class location: Room 101 of the Research Building (except on Sept 27 which meets in room 256),
College of Veterinary Medicine, NCSU.
Class time: Tuesday and Thursday. 3:30-4:45PM
Student Learning Objectives:
This course is designed to facilitate the students’ ability to gain a broad understanding of biomedical
research and molecular techniques. Through this course, students will gain:
� a foundation of knowledge for advanced courses applicable to a graduate degree in
Comparative Biomedical Sciences (e.g. CBS 762/770/787/795I, GN 703, BCH 703, etc.),
� information in comparative animal sciences (immunology, genomics, physiology,
pharmacokinetics),
� an understanding of infectious and emerging zoonotic diseases,
� an understanding of the role of epidemiology and public health in comparative biomedical
sciences,
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Course Overview:
A. Goals. This is a 3 credit, graduate level course designed for incoming CBS graduate students
and advanced undergraduate students interested in gaining a broad understanding of:
comparative genomics, comparative immunology, comparative physiology, pharmacokinetics,
emerging zoonotic diseases, the role of epidemiology and public health in comparative
biomedical sciences and translational research models and methods. This course will also
provide an overview of current technologies relevant to comparative biomedical research and
a foundation for implementing the scientific method (experimental design, data analyses,
statistics).
B. Class participation (5%). There will be frequent in-class discussions of assigned readings
(including research or review articles). Your participation in these discussions and discussion
in general is worth 5% of your final grade.
C. Written Review (20%). A written report is worth 20% of your final grade. This assignment can
be considered a “mini-review article”. Each student will submit a written Review based on a
topic suggested by an instructor (details will be discussed in class). The Research Proposal
should be 1500-2500 words, cite current literature and include figures and tables as needed.
Incorrect spelling, grammar and punctuation can influence this grade.
PLAGIARISM WILL NOT BE TOLERATED – MAKE SURE YOU UNDERSTAND THE
DEFINITION OF PLAGIARISM. The University policy on academic integrity can be found in
the Code of Student Conduct (found at
http://www.ncsu.edu/policies/student_services/student_discipline/POL11.35.1.php). We expect
students to complete this assignment on an individual basis. In addition, plagiarism (quoting
authority as your own without referencing a citation or source) will not be tolerated in the
preparation of this assignment.
D. Exams (75%). There will be 3 exams. Each exam is worth 25% of your final grade.
E. Grades:
Assignment of grades will be on the following basis:
A+ : 98 - 100% B+ : 87 - 89% C+ : 77 - 79% D+: 67 - 69%
A : 93 - 97% B : 83 - 86% C : 73 - 76% D : 63 - 66%
A- : 90 - 92% B- : 80 - 82% C- : 70 - 72% D- : 60 - 62%
F: Below 60%
Grades can be accessed via the course web page (http://moodle.wolfware.ncsu.edu/).
F. Attendance: Class attendance is mandatory. If you miss a class for any reason, you are
responsible to get notes from another student. Students who anticipate the necessity of being
absent from class due to the observation of a major religious observance must provide notice
of the dates to the Course Director, in writing, by the second class meeting. Please see
http://www.ncsu.edu/policies/academic_affairs/courses_undergrad/REG02.20.3.php for
additional details about university policies on attendance.
G. Disabilities. Reasonable accommodations will be made for students with recognized
disabilities. Students with disabilities are invited to schedule an appointment (by the second
class meeting) with the course director to discuss appropriate accommodations. In order to
take advantage of available accommodations, students must register with Disabilities Services
for Students at 1900 Student Health Center, Campus Box 7509, 515-7653,
http://www.ncsu.edu/provost/offices/affirm_action/dss/. For more information about NC State’s
policy on working with students with disabilities, please see:
http://www.ncsu.edu/policies/academic_affairs/courses_undergrad/REG02.20.1.php
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H. Cell Phones: Please turn off all cell phones, beepers, pagers etc. during class.
I. Participating Faculty: This course will be team taught by faculty in the CBS and related
Programs and include:
a. Baynes, Ronald 513-6261 ronald_baynes@ncsu.edu
b. Blikslager, Anthony 513-7725 anthony_blikslager@ncsu.edu
c. Correa, Maria 513-6253 maria_correa@ncsu.edu
d. Cullen, John 513-7720 john_cullen@ncsu.edu
e. Davis, Jen 513-6720 jennifer_davis@ncsu.edu
f. Fuller, Fred 515-7396 fred_fuller@ncsu.edu
g. Kennedy-Stoskopf, Suzanne 515-8111 suzanne_stoskopf@ncsu.edu
h. Law, Mac 515-7411 mac_law@ncsu.edu
i. Posner, Lysa 513-6558 lysa_posner@ncsu.edu
j. Saker, Korinn 513-6488 korinn_saker@ncsu.edu
k. Sherry, Barb 515-4480 barbara_sherry@ncsu.edu
l. Swanson, Cliff 513-6298 cliff_swanson@ncsu.edu
m. Thakur, Sid 513-0729 sid_thakur@ncsu.edu
n. Yoder, Jeff 515-7406 jeff_yoder@ncsu.edu
Course Evaluations:
Online class evaluations will be available for students to complete during the last 2 weeks of fall and
become unavailable before finals begin.
Students will receive an email message directing them to a website where they can login using their
Unity ID and complete evaluations. All evaluations are confidential; instructors will not know how any
one student responded to any question, and students will not know the ratings for any instructors.
Evaluation website: https://classeval.ncsu.edu/
Student help desk: classeval@ncsu.edu
More information about ClassEval: http://www.ncsu.edu/UPA/classeval/
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COURSE SCHEDULE – FALL 2012
Class Day 2011 Subject Reading lecturer
1 Th Aug 16
2 Tu Aug 21
3 Th Aug 23
CELL BIOLOGY – Structure and metabolism of
carbohydrates, protein and lipids
CELL BIOLOGY – Carbohydrate and lipid in
clinical and basic research
CELL BIOLOGY – Protein in clinical and basic
research
4 Tu Aug 28 CELL BIOLOGY – Transcriptional control
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TBA Saker
TBA Saker
TBA Saker
Alberts et al: Ch. 6: p 329-366; Ch. 7:
411-432; 440-447; 450-453
5 Th Aug 30 CELL BIOLOGY – Translational control Alberts et al: Ch. 6: p 336-410 Yoder
6 Tu Sept 4 PHYSIOLOGY – Cardiac Marieb & Hoehn (as reference) Swanson
7 Th Sept 6 PHYSIOLOGY – Pulmonary Marieb & Hoehn (as reference) Swanson
8 Tu Sept 11 PHYSIOLOGY – Renal Marieb & Hoehn (as reference) Posner
9 Th Sept 13 PHYSIOLOGY –Gastrointestinal
10 Tu Sept 18 EXAM 1
Blikslager Physiol Rev. 2007. 87:545-
64. AND Tomlinson et al. J Am Vet
Med Assoc. 2004. 224:1446-52
Yoder
Blikslager
11 Th Sept 20 PATHOLOGY – Basic pathology techniques TBA Cullen
12 Tu Sept 25 PATHOLOGY – Rodent necropsy techniques TBA Cullen
13* Th Sept 27* PATHOLOGY – Cell injury and cell death * McGavin and Zachary: Ch 1 Law
14 Tu Oct 2 PATHOLOGY – General pathology McGavin and Zachary: Ch 1 Law
Th Oct 4 NO CLASS – FALL BREAK
15 Tu Oct 9
INFECTIOUS DISEASE –
Introduction/Parasitology
TBA Fuller
16 Th Oct 11 INFECTIOUS DISEASE –Virology NA Sherry
17 Tu Oct 16 INFECTIOUS DISEASE – Bacteriology TBA Fuller
18 Th Oct 18
19 Tu Oct 23 EXAM 2
20** Th Oct 25**
21 Tu Oct 30
22 Th Nov 1
INFECTIOUS DISEASE – Immune responses to
infectious agents
PHARMACOLOGY – Drug Absorption and
Distribution
PHARMACOLOGY – Drug Clearance
(Metabolism & Excretion)
PHARMACOLOGY – Drug Receptor Interaction
& Protein Binding
23 Tu Nov 6 PHARMACOLOGY – Adverse drug reactions
24 Th Nov 8
25 Tu Nov 13
POPULATION MEDICINE – Ecology of
infectious disease
POPULATION MEDICINE – Epidemiology
Molecular Tools
TBA Fuller
Riviere: Chs 3 & 4 in Riviere and/or
Adams: Ch 3
Riviere: Chs 5 and 6 and/or
Adams: Ch 3
Baynes
Baynes
Adams: Ch 2 Baynes
Drug Reports; Kaufman & Shapiro;
Edwards and Aronson; Meyer
TBA
Davis
Kennedy-
Stoskopf
TBA Thakur
26 Th Nov 15 POPULATION MEDICINE – Statistics/methods TBA Correa
27*** Tu Nov 20***
POPULATION MEDICINE –Ecology of
infectious disease
Th Nov 22 NO CLASS – THANKSGIVING
Tu Nov 27 NO CLASS
28 Th Nov 29 EXAM 3
* Class meets in room 256
** A topic for your written Report must be finalized with the course director by Thursday, Oct 25, 2012.
*** A written Report is due on Tues, Nov 20, 2012. Details will be announced in class.
TBA
Kennedy-
Stoskopf