New Directions In STD Treatment - University of Hawaii

New Directions In STD Treatment - University of Hawaii New Directions In STD Treatment - University of Hawaii

16.01.2013 Views

Diagnostic Tests for Syphilis � Darkfield / DFA-TP � PCR � VDRL/RPR � FTA-abs / TP-PA (MHA-TP) � EIA

Syphilis EIA Tests �Treponemal test but test performance may be inferior to TP-PA (Captia and TrepChek) � Specificity concerns �Can be used for screening but if positive then need quantitative RPR/VDRL �Advantages if comparable sensitivity and specificity � Not miss prozones � Low cost �Both IgM and IgG tests available � No clinical value of IgM in adult syphilis diagnosis

Syphilis EIA Tests<br />

�Treponemal test but test performance may be<br />

inferior to TP-PA (Captia and TrepChek)<br />

� Specificity concerns<br />

�Can be used for screening but if positive then<br />

need quantitative RPR/VDRL<br />

�Advantages if comparable sensitivity and<br />

specificity<br />

� Not miss prozones<br />

� Low cost<br />

�Both IgM and IgG tests available<br />

� No clinical value <strong>of</strong> IgM in adult syphilis diagnosis

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