New Directions In STD Treatment - University of Hawaii

New Directions In STD Treatment - University of Hawaii New Directions In STD Treatment - University of Hawaii

16.01.2013 Views

Gonorrhea – Treatment Issues � Fluoroquinolones NOT recommended for: � Acquisition in CA or Hawaii or other areas with high prevalence of FQ resistance � MSM � Any foreign acquisition- Europe, Middle East, Asia, Pacific � Limited options in cephalosporin allergic patients: � Spectinomycin is no longer manufactured � CDC recommends desensitization* � Could be a special case to consider azithromycin* * Discussed at the 2006 Guidelines Meeting

Gonorrhea Treatment of Urogenital Infections if Fluoroquinolone Resistance Recommended regimens: � Ceftriaxone 125 mg IM x 1* � Cefixime 400 mg PO x 1* Alternative regimens: � Spectinomycin 2 g IM x 1** � Single-dose cephalosporin regimens � Cefpodoxime 400 mg po x 1 � Cefuroxime 1 g po x 1 Azithromycin 2 gm is not recommended by CDC Co-treat for chlamydia unless ruled out by NAAT * suspension may be available ** currently not manufactured *Preferred and only recommended regimen for pharyngeal infection

Gonorrhea <strong>Treatment</strong> <strong>of</strong> Urogenital<br />

<strong>In</strong>fections if Fluoroquinolone Resistance<br />

Recommended regimens:<br />

� Ceftriaxone 125 mg IM x 1*<br />

� Cefixime 400 mg PO x 1*<br />

Alternative regimens:<br />

� Spectinomycin 2 g IM x 1**<br />

� Single-dose cephalosporin regimens<br />

� Cefpodoxime 400 mg po x 1<br />

� Cefuroxime 1 g po x 1<br />

Azithromycin 2 gm is not recommended by CDC<br />

Co-treat for chlamydia unless ruled out by NAAT<br />

* suspension may be available<br />

** currently not manufactured<br />

*Preferred and only recommended<br />

regimen for pharyngeal infection

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