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Priv.-Doz. Dr. med. Dipl. Phys. Rotraut Mößner

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<strong>Priv</strong>.-<strong>Doz</strong>. <strong>Dr</strong>. <strong>med</strong>. <strong>Dipl</strong>. <strong>Phys</strong>. <strong>Rotraut</strong> <strong>Mößner</strong><br />

Klinische Tätigkeit: Leiterin der Spezialsprechstunde für Psoriasis und Psoriasisarthritis<br />

Klinische Studien bei der Psoriasis<br />

Allgemeine Ambulanz<br />

Sonographie der Haut<br />

Phlebologie<br />

Weitere Tätigkeiten: Leiterin des Mykologischen Labors<br />

Forschungsschwerpunkt: Systemtherapeutika bei der Psoriasis<br />

Genetische Grundlagen der Psoriasis<br />

PPARgamma Agonisten beim Malignen Melanom<br />

Genetische Grundlagen des Malignen Melanoms<br />

Ausgewählte Publikationen: Psoriasis und Autoimmunerkrankungen<br />

1. Mössner R, Schön MP, Reich K: TNF-antagonists in the therapy of<br />

psoriasis. Clinics in Dermatology (im <strong>Dr</strong>uck)<br />

2. Kingo K, Mössner R, Rätsep R, Raud K, Krüger U, Silm H, Vasar E,<br />

Reich K, Koks S. Association analysis of IL20RA and IL20RB genes in<br />

psoriasis. Genes Immun (im <strong>Dr</strong>uck)<br />

3. Mössner R, Thaci D, Mohr J, Paetzold S, Bertsch HP, Krüger U, Reich<br />

K. Manifestation of palmoplantar pustulosis during or after infliximab<br />

therapy for plaque-type psoriasis – report of 5 cases. Archives Derm<br />

Res (im <strong>Dr</strong>uck)<br />

4. Radtke MA, Mössner R, Augustin M, Reich K: Psoriasis-Arthritis -<br />

Therapeutische Strategien: je früher desto besser. Der Deutsche<br />

Dermatologe 6:1-4 (2007)<br />

5. Radtke MA, Mössner R, Augustin M, Reich K: Psoriasis Arthritis: Klinik,<br />

Pathogenese und Diagnostik. Der Deutsche Dermatologe 5:2-8 (2007)<br />

6. Kingo K, Mössner R, Kõks S, Rätsep R, Krüger U, Vasar E, Reich K,<br />

Silm H. Association analysis of IL19, IL20 and IL24 genes in<br />

palmoplantar pustulosis. BJD 156: 646-52 (2007)<br />

7. Mössner R, Reich K: Biologics in der Therapie der Psoriasis –<br />

unerwünschte Effekte an der Haut. Allergo Journal 15: 492-500 (2006)<br />

8. Mössner R, Reich K: Infliximab in the treatment of psoriasis. Expert<br />

Rev Dermatol 1: 515-26 (2006)<br />

9. Mössner R, Kingo K, König IR, Krüger U, Ziegler U, Neumann Ch, Silm<br />

H, Westphal GA, Reich K: Association of TNFA–238 and –308 promoter<br />

polymorphisms with psoriasis vulgaris but not with pustulosis<br />

palmoplantaris in an Estonian population. J Invest Dermatol 124: 282-4<br />

(2005)<br />

10. Mössner R, Reich K: Pathogenetische Aspekte der Psoriasis-Arthritis.<br />

Haut 1: 19-24 (2005)<br />

11. Mössner R, Reich K: Infliximab: Stellenwert in der Therapie der<br />

Psoriasis. Hautarzt 56: 831-8 (2005)<br />

12. Mössner R, Kaiser R, Matern P, Krüger U, Westphal GA, Brockmöller<br />

J, Ziegler A, Neumann Ch, König I, Reich K: Variations in the genes<br />

encoding the peroxisome proliferator-activated receptors a and g in<br />

psoriasis. Arch Dermatol Res 296: 1-5 (2004)


13. Mössner R, Tings T, Beckmann I, Neumann Ch, Paulus W, Reich K. A<br />

close-up look at autoimmune muscle disorders: Association of Lambert-<br />

Eaton myasthenic syndrome with dermatomyositis. Scand J Rheum 33:<br />

271-5 (2004)<br />

14. Mössner R, Beckmann I, Hallermann C, Neumann Ch, Reich K:<br />

Granulocyte colony-stimulating factor (G-CSF)-induced psoriasiform<br />

dermatitis resembles psoriasis with regard to abnormal cytokine<br />

expression and epidermal activation. Exp Dermatol 13: 340-6 (2004)<br />

15. Reich K, Mössner R, König IR, Westphal GA, Ziegler A, Neumann Ch:<br />

Promoter polymorphisms of the genes encoding tumor necrosis factoralpha<br />

and interleukin-1beta are associated with different subtypes of<br />

psoriasis characterized by early and late disease onset. J Invest<br />

Dermatol 118: 155-63 (2002)<br />

16. Reich K, Hummel KM, Beckmann I, Mössner R, Neumann Ch:<br />

Treatment of severe psoriasis and psoriatic arthritis with leflunomide. Br<br />

J Dermatol 146: 335-336 (2002)<br />

Neurodermitis und Kontaktekzem<br />

1. Reich K, Westphal G, König IR, Mössner R, Krüger U, Ziegler A,<br />

Neumann Ch , Schnuch A. Association of allergic contact dermatitis with<br />

a promoter polymorphism in the IL16 gene. J Allergy Clin Immunol. 112:<br />

1191-4 (2003)<br />

2. Westphal GA, Schnuch A, Mössner R, König IR, Kränke B, Hallier E,<br />

Ziegler A, Reich K. Cytokine gene polymorphisms in allergic contact<br />

dermatitis. Contact Dermatitis 48: 93-8 (2003)<br />

3. Jung Th, Mössner R, Neumann C. Naïve CD4+ T cells from patients<br />

with atopic dermatitis show an aberrant maturation towards IL-4producing<br />

skin-homing CLA+ cells. Exp Dermatol 12: 555-62 (2003)<br />

4. Reich K, Westphal GA, König IR, Mössner R, Schupp P, Gutgesell C,<br />

Hallier E, Ziegler A, Neumann Ch. Cytokine gene polymorphisms in<br />

atopic dermatitis. Br J Dermatol. 148: 1237-41 (2003)<br />

5. Jung Th, Mössner R, Dieckhoff K, Heidrich S, Neumann Ch.<br />

Mechanisms of deficient IFN-g production in atopic diseases. IFN-g<br />

production by CD4+ effector T cells generated from naive precursors is<br />

restored by priming in the presence of high doses of IL-2 or IL-12.<br />

Clinical Experimental Allergy 29: 912-919 (1999)<br />

Melanom<br />

1. Mössner R, Anders N, König IR, Krüger U, Schmidt D, Berking C,<br />

Ziegler A, Brockmöller J, Kaiser R, Volkenandt M, Westphal GA, Reich<br />

K. Variations of the melanocortin-1 receptor and the glutathione-S<br />

transferase T1 and M1 genes in cutaneous malignant melanoma. Arch<br />

Dermatol Res 298: 371-9 (2007)<br />

2. Mössner R, Schulz U, Krüger U, Middel P, Schinner S, Füzesi L,<br />

Neumann Ch, Reich K. Agonists of peroxisome proliferator-activated<br />

receptor gamma inhibit cell growth in malignant melanoma. J Invest<br />

Dermatol 119: 576-82 (2002)<br />

3. Mössner R, Jankowski F, König IR, Krüger U, Anders N, Westphal G,<br />

Berking C, Brockmöller J, Ziegler A, Kaiser R, Volkenandt M, Reich K.<br />

Variations in the peroxisome proliferator-activated receptor-gamma<br />

gene and melanoma risk. Cancer Letters 246: 218-23 (2007)


Signaltransduktion<br />

1. Gillis KD, Mössner R, Neher E. Protein kinase C enhances exocytosis<br />

from chromaffin cells by increasing the size of the readily releasable<br />

pool of secretory granules. Neuron 16: 1209-1220 (1996)

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