The Mitochondrial Free Radical Theory of Aging - Supernova: Pliki

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Table 3.3. Reactions involving or protecting against LECs
The Mitochondrial Free Radical Theory of Aging
no. type reagent(s) product(s) notes
1 a Q• — + O2 Q + O2• —
2 d O2• — + H + HO2• mainly at pH < 4.7 2
3 f HO2• O2• — + H + mainly at pH < 4.7 2
4 c O2• — + O2• — + 2H + O2 + H2O2 catalyzed by SOD
5 c HO2• + O2• — +H + 1 O2 + H2O2 not catalyzed
6 c HO2• + HO2• 1 O2 + H2O2 not catalyzed
7 a O2• — + Fe 3+
O2 + Fe 2+ • Cu 2+ can replace Fe 3+
8 a H2O2 + Fe 2+ • + H + HO• + H2O + Fe 3+ Cu + •,Q• — can
replace Fe 2+
9 g H2O2 + H2O2 2H2O + O2 catalyzed by CAT
10 g H2O2 + 2GSH 2H2O + GSSG catalyzed by GPx
11 g GSSG + NADPH +H + 2GSH + NADP + catalyzed by GR
12 b GSH + L• GS• + LH
13 e GS• + GS• GSSG
14 b HO• + LH H2O +L•
15 b HO2• + LH H2O2 + L•
16 b La• + LbH LaH + Lb•
17 d L• + O2 LOO•
18 b LaOO• + LbH LaOOH +Lb•
19 a LOOH + Fe 2+ • + H +
LO• + H2O + Fe 3+
20 f LaO• Ld• + LcO
Cu + •,Q• — can
replace Fe 2+
21 e La• + Lb• Lc cross-linking