The Mitochondrial Free Radical Theory of Aging - Supernova: Pliki
The Mitochondrial Free Radical Theory of Aging - Supernova: Pliki
The Mitochondrial Free Radical Theory of Aging - Supernova: Pliki
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204<br />
Ethidium bromide 103<br />
Eukaryotes 6<br />
Evolution <strong>of</strong> lifespan<br />
see lifespan, evolution <strong>of</strong><br />
Exercise 115<br />
Exotherms<br />
see poikilotherms<br />
Extrinsic mortality rate 61<br />
Eye 56-58, 192<br />
see also muscle, extraocular<br />
see also pigmented epithelium<br />
F<br />
Facultative aerobes 103<br />
FAD<br />
see flavin adenine dinucleotide<br />
FADH 2<br />
see flavin adenine dinucleotide<br />
Fatty acids 12, 14, 47-50<br />
breakdown 12<br />
import into mitochondria 14<br />
structure 48<br />
Fatty acyl CoA dehydrogenase 16, 18-19, 140<br />
FCCP 145<br />
Fecundity (maintenance)<br />
see negligible senescence, fecundity in<br />
Feedback 58-60<br />
negative 58-59<br />
positive 60<br />
Fenton chemistry 39-42, 108<br />
Ferricyanide 104, 108<br />
Ferritin 108<br />
Fibroblasts 30, 56<br />
cell division rate in vivo 30<br />
Finch CE, 72<br />
Flavin adenine dinucleotide 11, 14, 105-106,<br />
140, 183<br />
Flies<br />
see Drosophila<br />
FLP recombination 181<br />
Foam cell 54<br />
<strong>Free</strong> radicals 25, 35-44, 65-67<br />
defined 35<br />
properties<br />
Fridovich I 2<br />
Fruit flies<br />
see Drosophila<br />
Fusion (mitochondrial)<br />
see mitochondrial fusion<br />
G<br />
Galactose 183<br />
<strong>The</strong> <strong>Mitochondrial</strong> <strong>Free</strong> <strong>Radical</strong> <strong>The</strong>ory <strong>of</strong> <strong>Aging</strong><br />
GDP<br />
see guanosine diphosphate<br />
General import pore<br />
see Tom proteins<br />
Gene therapy (general) 170-171, 179<br />
error rate 177<br />
Gene therapy (mitochondrial)<br />
see nuclear complementation <strong>of</strong> mtDNA<br />
Genetic code (<strong>of</strong> mtDNA)<br />
see mitochondrial DNA, genetic code<br />
Genetic drift 119-120, 125<br />
Germ-line transformation 171<br />
Gingold E 94, 98, 160<br />
Glia (cell division rate in vivo) 30<br />
Glomeruli 58<br />
Glucose 54, 73, 103, 105, 183<br />
as energy source<br />
see glycolysis<br />
as reductant<br />
see glycation<br />
Glutamate/aspartate carrier 123<br />
Glutathione peroxidase 108, 110, 122<br />
Glutathione reductase 122<br />
Glycation 56, 60, 73, 88<br />
reversal 88<br />
Glycerol 47-48<br />
Glycerophosphate shuttle<br />
see s,n-glycerophosphate shuttle<br />
Glycolysis 12-13<br />
Glycoproteins 56<br />
Glycoxidation 60<br />
Gompertz B 186<br />
Gompertz distribution 196-197<br />
Grotthuss mechanism<br />
see conduction by protons<br />
GTP<br />
see guanosine triphosphate<br />
Guanine 25-26, 55<br />
Guanosine diphosphate 15, 105<br />
Guanosine triphosphate 15, 105, 123<br />
Guthrie A 144<br />
H<br />
Haemin 108-109<br />
Haemoglobin 108<br />
Haemopexin 108<br />
Haldane JBS 70<br />
Haptoglobin 108<br />
Harman D 2, 65-67, 75, 121<br />
HDL<br />
see high density lipoprotein<br />
Head group (<strong>of</strong> a phospholipid) 47, 142<br />
Healthspan<br />
see lifespan, in good health