The Mitochondrial Free Radical Theory of Aging - Supernova: Pliki

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MOLECULAR BIOLOGY INTELLIGENCE UNIT 9 The Mitochondrial Free Radical Theory of Aging Aubrey D.N.J. de Grey Department of Genetics University of Cambridge R.G. LANDES COMPANY AUSTIN, TEXAS U.S.A.
ISBN: 1-57059-564-X MOLECULAR BIOLOGY INTELLIGENCE UNIT The Mitochondrial Free Radical Theory of Aging Copyright © 1999 R.G. Landes Company R.G. LANDES COMPANY Austin, Texas, U.S.A. All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Printed in the U.S.A. Please address all inquiries to the Publishers: R.G. Landes Company, 810 South Church Street, Georgetown, Texas, U.S.A. 78626 Phone: 512/ 863 7762; FAX: 512/ 863 0081 While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein. Library of Congress Cataloging-in-Publication Data The Mitochondrial Free Radical Theory of Aging/ Aubrey D.N.J. de Grey p. cm. -- (Molecular biology intelligence unit) Includes bibliographical references and index ISBN 1-57059-564-X (alk. paper) 1. Aging--molecular aspects. 2. Mitochondrial pathology. 3. Mitochondrial DNA-- Abnormalities. 4. Free radicals (Chemistry)-- Pathophysiology. I. Title II. Series [DNLM: 1. DNA, Mitochondrial -- metabolism. 2. Aging. 3. Free Radicals -metabolism. 4. Lipids -- metabolism. QU 58.5 D278m 1999] Qp86.D4 1999 571.8'7819 -- dc21 DNLM/DLC 99-27037 for Library of Congress CIP
Page 1: COMPANY de Grey The Mitochondrial F
Page 5 and 6: 7. The Status of Gerontological The
Page 7 and 8: 17. Conclusion: The Role of the Ger
Page 9 and 10: I cannot overstate my profound grat
Page 11 and 12: CHAPTER 1 Introduction 1.1. What Is
Page 13 and 14: Introduction Some may feel that all
Page 15 and 16: 6 The Mitochondrial Free Radical Th
Page 17 and 18: 8 The Mitochondrial Free Radical Th
Page 19 and 20: 10 The Mitochondrial Free Radical T
Page 27 and 28: 18 Fig. 2.7. The respiratory chain.
Page 33 and 34: 24 Fig. 2.9. Types of protein impor
Page 35 and 36: 26 Fig. 2.10. Why the DNA bases pai
Page 43 and 44: CHAPTER 3 An Introduction to Free R
Page 45 and 46: An Introduction to Free Radicals Ta
Page 51 and 52: An Introduction to Free Radicals Fi
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An Introduction to Free Radicals Re
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48 The Mitochondrial Free Radical T
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CHAPTER 6 History of the Mitochondr
Page 73 and 74:
History of the Mitochondrial Free R
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CHAPTER 7 The Status of Gerontologi
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The Status of Gerontological Theory
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The Status of Gerontological Theory
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CHAPTER 8 The Search for How Mutant
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The Search for How Mutant mtDNA is
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CHAPTER 9 The Search for How So Few
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The Search for How So Few Anaerobic
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CHAPTER 10 Frequently-Asked Questio
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Frequently-Asked Questions The effe
Page 125 and 126:
Frequently-Asked Questions Table 10
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Frequently-Asked Questions through
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Frequently-Asked Questions has been
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Frequently-Asked Questions SOS, sin
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Frequently-Asked Questions for almo
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Frequently-Asked Questions Fig. 10.
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Frequently-Asked Questions Fig. 10.
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Frequently-Asked Questions of elect
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Frequently-Asked Questions Referenc
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Frequently-Asked Questions 45. Clay
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CHAPTER 11 A Challenge from Textboo
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A Challenge from Textbook Bioenerge
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160 The Mitochondrial Free Radical
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CHAPTER 14 Ablation of Anaerobic Ce
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Ablation of Anaerobic Cells: Techni
Page 181 and 182:
CHAPTER 15 Transgenic Copies of mtD
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Transgenic Copies of mtDNA: Techniq
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CHAPTER 16 Prospective Impact on th
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Prospective Impact on the Healthy H
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Prospective Impact on the Healthy H
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Index Symbols “~”, 19 A Acetald
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Index Copper 35, 107 see also trans
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Index Heart comparison to man-made
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Index genetic code 23, 115-118, 177
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Index Perhydroxyl radical 41, 122,
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Index protonation see protonation (
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MOLECULAR BIOLOGY INTELLIGENCE UNIT
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