The Mitochondrial Free Radical Theory of Aging - Supernova: Pliki

A Challenge from Textbook Bioenergetics and Free Radical Chemistry
Fig. 11.7. Routes of proton flow according to the electrodic hypothesis.
continue until δpc and δpm have been completely dissipated. This can be depicted another
way (Fig. 11.7): the currents at C and D are required to equal those at A and B, but if there
is a δpc or δpm they cannot.
11.3.7. Resuscitation of the Electrodic Hypothesis
This story (so far) closes with my very recent contribution, 30 which proposes to resolve
this difficulty and thereby render the electrodic model admissible again. The dissipation of
δpc and δpm can be avoided if the proton current that they drive is somehow compensated
by a separate current the other way. I realized that it was an oversimplification to reduce the
system to just the mitochondrial membrane, the respiratory chain and the ATPase, because
steady-state OXPHOS also requires the steady-state operation of several metabolite carriers.
The one of most interest is the phosphate carrier, which has a high rate of turnover (once
per ATP molecule generated in the matrix) and also, crucially, transports phosphate in
153