14.01.2013 Views

1 BETA-CELL FAILURE IN DIABETES AND PRESERVATION BY ...

1 BETA-CELL FAILURE IN DIABETES AND PRESERVATION BY ...

1 BETA-CELL FAILURE IN DIABETES AND PRESERVATION BY ...

SHOW MORE
SHOW LESS

You also want an ePaper? Increase the reach of your titles

YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.

2<br />

14. Weyer C,Bogardus C,Mott DM,Pratley RE 1999 The natural history of insulin<br />

secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus<br />

J Clin Invest 104:787-794<br />

15, Gerich JE 2003 Contributions of insulin resistance and insulin-secretory defects to the<br />

pathogenesis of Type 2 diabetes mellitus. Mayo Clin Proc 78:447-456<br />

16.Elbein SC,Hasstedt SJ,Wegner K,Kahn SE 1999 Heritability of pancreatic β-cell<br />

function among nondiabetic members of Caucasian familial type 2 diabetic kindreds. J<br />

Clin Endocrinol Metab 84:1398-1403<br />

17.Elbein SC,Wegner K,Kahn SE 2000 Reduced β-cell compensation to the insulin<br />

resistance associated with obesity in members of Caucasian familial type 2 diabetic<br />

kindreds Diabetes Care 23:221-227<br />

18. Wajchenberg BL 2000 Subcutaneous and visceral adipose tissue :Their relation to the<br />

metabolic syndrome Endocr Rev 21:697-738<br />

19 Gerich JE 1998 The genetic basis of type 2 diabetes mellitus : impaired insulin<br />

secretion versus impaired insulin sensitivity Endocr Rev 19:491-503 .<br />

20.Gerich JE 2000 Clinical perspective.Insulin resistance is not necessarily an essential<br />

component of type 2 diabetes.J Clin Endocrinol Metab 85:2113-2115<br />

21. Donath MY,Halban PA 2004. Decreased beta-cell mass in diabetes:significance<br />

,mechanisms and therapeutic implications. Diabetologia 47:581-589<br />

22. Kahn SE 1996 Regulation of β-cell function in vivo:.from health to disease Diabetes<br />

Rev 4:372-389<br />

23 .Roder ME,Porte DJ,Schwartz RS,Kahn SE 1998 Disproportionately elevated proinsulin<br />

levels reflect the degree of impaired β cell secretory capacity in patients with noninsulindependent<br />

diabetes mellitus.J Clin Endocrinol Metab 83:604-608<br />

24. Gerich JE 2002 Is reduced first-phase insulin release the earliest detectable abnormality<br />

in individuals destined to develop type 2 diabetes ? Diabetes 51(Suppl 1):S117-S121<br />

25. Mitrakou A,Kelley D,Mokan M,Veneman T,Pangburn T,Reilly J,Gerich JE 1992 Role<br />

of reduced suppression of glucose production and diminished early insulin release in<br />

impaired glucose tolerance N Engl J Med 326:22-29<br />

26. Bergstrom RW,Wahl PW,Leonetti DL,Fujimoto WY 1990 Association of fasting<br />

glucose levels with delayed secretion of insulin after oral glucose in subjects with glucose<br />

intolerance.J Clin Endocrinol Metab 71:1447-1453

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!