omation mbers - Society for Laboratory Automation and Screening
omation mbers - Society for Laboratory Automation and Screening
omation mbers - Society for Laboratory Automation and Screening
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
3:00 pm Thursday, February 5 Aut<strong>omation</strong> Applications in Process R&D Room A2<br />
Rick Sidler<br />
Merck Research Laboratories<br />
R800-C260<br />
P.O. Box 2000<br />
Rahway, New Jersey 07065<br />
rick_sidler@merck.com<br />
Parallel <strong>Screening</strong> <strong>and</strong> Optimization of Catalytic High-Pressure Reactions<br />
The application of selective catalytic reactions <strong>for</strong> the preparation of pharmaceutically interesting compounds is a<br />
bourgeoning field. The variety of accessible reaction types, coupled with recently developed catalyst <strong>and</strong> lig<strong>and</strong><br />
systems, challenge the researcher’s ability to screen <strong>and</strong> optimize these reactions. In addition, many of these<br />
interesting reactions employ conditions of high pressure, coupled with air <strong>and</strong>/or moisture sensitive catalysts<br />
to effect chemo-, diastereo-, or enantio-selective trans<strong>for</strong>mations. We have applied customized hardware <strong>and</strong><br />
software solutions to allow <strong>for</strong> efficient screening, optimization, <strong>and</strong> analysis of these reactions.<br />
3:00 pm Tuesday, February 3 Genomics – Analytical Room A1<br />
Robert Cotter<br />
Johns Hopkins University<br />
725 North Wolfe Street<br />
Baltimore, Maryl<strong>and</strong> 21205<br />
rcotter@jhmi.edu<br />
95<br />
Co-Author(s)<br />
Ben D. Gardner<br />
Sara McGrath<br />
Miniaturizing the Time-of-Flight Mass Spectrometer While Maintaining High Per<strong>for</strong>mance<br />
The time-of-flight mass spectrometer is unique in its ability to maintain high mass range when its size is reduced.<br />
Since sensitivity is also high, the major limitation in per<strong>for</strong>mance is mass resolution. In an approach developed in<br />
our laboratory a pulsed extraction, high order energy-focusing source is used to focus ions at the end of a three<br />
inch flight tube with mass resolutions up to 1200. In addition, a novel TOF mass spectrometer in which source <strong>and</strong><br />
analyzer are combined in a single non-linear <strong>and</strong> time-dependent field has been developed. This instrument does<br />
not require extraction lenses or grids, <strong>and</strong> the electric field is defined by an “endcap” geometry. These instruments<br />
are currently being used <strong>for</strong> bioagent detection <strong>and</strong> proteomics studies.<br />
PODIUM ABSTRACTS
Change language