omation mbers - Society for Laboratory Automation and Screening

3:30 pm Wednesday, February 4 HT Chemistry – New Strategies Room B3
Mark Bradley
University of Southampton
Highfield, Southampton
Hants, SO17 1BJ United Kingdom
mb14@soton.ac.uk
Real Time Combinatorial Arrays and Assays for Proteases, Kinases, and Transfection Agents
This presentation will cover the interactions between biology, chemistry and chemical technology and will
include: (a). New, highly sensitive method for protease (or kinase) analysis and screening, with the potential to
screen 100,000 substrates in a single pass. (b). Chip based library screening and cellular binding assays. (c). The
development of highly efficient molecular transporters for both single cells and slice cultures and array based
screening of libraries of molecular transporters to enable the development of “transfection chips”.
4:00 pm Wednesday, February 4 HT Chemistry – New Strategies Room B3
Thomas Smith
GlaxoSmithKline
New Frontiers Science Park (North)
Third Avenue
Harlow, Essex, CM19 5AW United Kingdom
thomas_j_smith@gsk.com
High Throughput Drug Discovery
The pharmaceutical industry is coming under increasing pressure to deliver new medicines and speed up the drug
discovery process. Hence, chemists are looking for ways to improve their methods of compound production. The
traditional one product at a time approaches are now giving way to faster and more cost effective, high throughput
chemistry methodologies. Routinely, robotic chemical synthesisers are used to carry out parallel reactions on
multiple substrates. Hundreds to thousands of compounds can now be prepared, analyzed and purified in
the time taken to prepare just a few by conventional methods. The presentation will focus on the automation
and technology used at GSK to achieve high throughput compound production and purification as well as the
importance of integrating the many components of this complex process.
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PODIUM ABSTRACTS