omation mbers - Society for Laboratory Automation and Screening
omation mbers - Society for Laboratory Automation and Screening
omation mbers - Society for Laboratory Automation and Screening
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TekCel Workshop Lunch 2 12:30 – 2:00 pm Room J2<br />
TekCel, Inc.<br />
103 South Street<br />
Hopkinton, Massachusetts 01748<br />
(508) 544-7000; (508) 544-7001 fax<br />
info@tekcel.com<br />
Stability of Compounds Stored in TekCel Plate Management System.<br />
Application of New Approaches <strong>for</strong> Ultra-High-Throughput Analysis of Compound Stability<br />
Presenter: James Connelly, Ph.D.<br />
Collections of compounds used <strong>for</strong> pharmaceutical lead generation are both a major asset <strong>and</strong> an opportunity<br />
<strong>for</strong> drug discovery. There<strong>for</strong>e, protection <strong>and</strong> preservation of this high-value resource is of supreme importance.<br />
Stability of compounds stored in DMSO solutions can be increased by application of conditions such as inert<br />
atmosphere <strong>and</strong> low temperature. The TekCel Plate Management System has been used <strong>for</strong> over 1.5 years to store<br />
combinatorial libraries at the Aventis Combinatorial Technologies Center. Increased surveillance <strong>and</strong> continuous<br />
QC of stored collections can be facilitated by new technology <strong>for</strong> ultra-high-throughput chromatography <strong>and</strong><br />
mass spectrometric analysis. Preliminary results on the application of new analytical technologies <strong>and</strong> the relative<br />
stability of these drug discovery samples will be presented.<br />
Thermo Electron Workshop Lunch 12:30 – 2:00 pm Room J3<br />
Thermo Electron<br />
5344 John Lucas Drive<br />
Burlington, Ontario L7L 6A6 Canada<br />
(905) 332-2000 x 319; (905) 332-1114 fax<br />
christy.jacobs@thermo.com<br />
Thermo Electron’s KingFisher ® – A Novel High Throughput Plat<strong>for</strong>m <strong>for</strong> Protein<br />
Purification Applications<br />
Thermo will be presenting a flexible customer solution <strong>for</strong> recombinant protein purification based on magnetic<br />
particles. This solution combines Thermo’s unique KingFisher purification technology <strong>and</strong> Dynal Biotech’s<br />
Dynabeads ® TALON ® , offering rapid protein purification with high-quality results. Purified proteins are ready <strong>for</strong><br />
use in a variety of downstream applications such as screening <strong>for</strong> new drugs <strong>and</strong> drug targets <strong>and</strong> studying DNAprotein<br />
or protein-protein interactions.<br />
Fully functional high-purity proteins can be isolated with excellent reproducibility <strong>and</strong> increased sensitivity.<br />
This robust <strong>and</strong> reliable method can purify up to 96 samples in less than 30 minutes. Data showing excellent<br />
per<strong>for</strong>mance of the new solution will be presented.<br />
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