omation mbers - Society for Laboratory Automation and Screening
omation mbers - Society for Laboratory Automation and Screening
omation mbers - Society for Laboratory Automation and Screening
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IDBS Workshop 12:00 – 1:30 pm Room C3<br />
IDBS<br />
2 Occam Court, Surrey Research Park<br />
Guild<strong>for</strong>d GU2 7QB, United Kingdom<br />
44 (0) 1483 595 010; 44 (0) 1483 595 001 fax<br />
mstrangwick@id-bs.com<br />
Practical Methods <strong>and</strong> Business Rules <strong>for</strong> Automating Potency Data Processing<br />
This workshop will discuss business rules <strong>for</strong> processing potency data. Key questions that will be addressed<br />
include:<br />
QC of controls/st<strong>and</strong>ards<br />
• What calculations? • What limits?<br />
Fitting data to a model<br />
• Which model(s)? • What parameter settings?<br />
• Data point weighting/exclusion methods? • Allow extrapolation?<br />
• Significance level <strong>for</strong> activity? • What goodness-of-fit calculations <strong>and</strong> limits?<br />
• What combination of descriptors most<br />
completely describes activity?<br />
Assay Variability<br />
• What calculations? • What limits?<br />
The implementation <strong>and</strong> en<strong>for</strong>cement of business rules <strong>for</strong> high-throughput processing will also be considered.<br />
Millipore Corporation Workshop Lunch 12:00 – 1:30 pm Room J4<br />
Millipore Corporation<br />
290 Concord Road<br />
Billerica, Massachusetts 01821<br />
(800) 645-5476; (800) 645-5439 fax<br />
Starting From Scratch: Implementation of an Automated High Throughput Method <strong>for</strong><br />
Determining Aqueous Compound Solubility in Drug Discovery<br />
There is growing awareness of the importance of measuring aqueous solubility in compound profiling, medicinal<br />
chemistry, <strong>and</strong> especially in conjunction with lead optimization. Methods that are currently available to measure<br />
solubility have insufficient throughput <strong>and</strong> may require too much compound to be useful <strong>for</strong> most screening <strong>and</strong><br />
early ADME applications. In<strong>for</strong>mation will be presented that can be used to implement, automate, <strong>and</strong> validate<br />
a robust, reliable, <strong>and</strong> high throughput method <strong>for</strong> determining aqueous compound solubility based on the use<br />
of a new, 96-well device, MultiScreen* Solubility Filter Plate. Discussion topics will include sample requirements,<br />
detailed protocols, aut<strong>omation</strong> <strong>and</strong> analytical options, <strong>and</strong> the ability to per<strong>for</strong>m on-line data acquisition <strong>and</strong><br />
analysis. Data detailing assay per<strong>for</strong>mance, sample throughput, <strong>and</strong> correlation with established, low throughput<br />
methodologies will be presented.<br />
239<br />
INDUSTRY WORKSHOPS
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