omation mbers - Society for Laboratory Automation and Screening
omation mbers - Society for Laboratory Automation and Screening
omation mbers - Society for Laboratory Automation and Screening
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WP040<br />
Fiona Payne<br />
Zinsser Analytic GmbH<br />
Eschborner L<strong>and</strong>strasse 135<br />
FrankfurtD-60489 Germany<br />
info@zinsser-analytic.com<br />
Aut<strong>omation</strong> Plat<strong>for</strong>m <strong>for</strong> Salt Prescreening <strong>and</strong> Polymorph <strong>Screening</strong> Studies<br />
211<br />
Co-Author(s)<br />
Werner Zinsser<br />
Polymorphism has become a concern in today’s pharmaceutical research labs as it affects a number of issues<br />
in pharmaceutical systems varying from processing characteristics to bioavailability. During thr pre-<strong>for</strong>mulation<br />
stage of drug development, polymorph screening is a tedious <strong>and</strong> time-consuming process. Zinsser Analytic<br />
has developed Crissy, an automated liquid <strong>and</strong> powder h<strong>and</strong>ling plat<strong>for</strong>m <strong>for</strong> salt pre-screening <strong>and</strong> polymorph<br />
screening studies. This plat<strong>for</strong>m automates the necessary steps <strong>for</strong> extensive crystallisation using different<br />
solvents, temperatures, concentrations, agitation <strong>and</strong> pH-measurement. A special Crissy reactor block has been<br />
designed to directly present the crystals to the XRPD system without any additional sampling steps. The top of<br />
the reactor bottoms is ideal <strong>for</strong> XRPD-detection. Cross contamination caused by electrostatic <strong>for</strong>ce moving the<br />
powders, is minimized as the detector block itself is grounded <strong>and</strong> the individual reactor cavities are separated in<br />
from each other the “up”-position.<br />
WP041<br />
Jonathan Petersen<br />
Molecular Devices Corp.<br />
Instrument R&D<br />
1311 Orleans Drive<br />
Sunnyvale, Cali<strong>for</strong>nia 94089<br />
jon_petersen@moldev.com<br />
Co-Author(s)<br />
AquaMax DW4: A Flexible Tool <strong>for</strong> Heterogeneous 1536 Assays<br />
Co-Author(s)<br />
Jeannie Nguyen<br />
Annegret Boge<br />
Gayle Teixeira<br />
The AquaMax DW4 is a new liquid h<strong>and</strong>ling instrument <strong>for</strong> assembly of screening assays in 96, 384 <strong>and</strong> 1536<br />
<strong>for</strong>mats. Because it can dispense up to four different assay components, the AquaMax can assemble assays of<br />
varying complexity. It is also a plate washer, thus enabling heterogeneous assays such as ELISAs. The AquaMax<br />
can dispense volumes as small as 0.5 µL to enable miniaturized assays, or up to 320 µL. The AquaMax has high<br />
throughput, making it suitable <strong>for</strong> screening applications. It can be used to dispense liquid reagents as well as<br />
suspensions of beads or cells. Both aspiration <strong>and</strong> dispensing are gentle enough <strong>for</strong> cellular assays that require<br />
washing. This combination of per<strong>for</strong>mance <strong>and</strong> flexibility makes the AquaMax Liquid H<strong>and</strong>ler a powerful tool<br />
<strong>for</strong> assembling assays <strong>for</strong> drug discovery. The poster will present basic per<strong>for</strong>mance data <strong>for</strong> the dispenser <strong>and</strong><br />
washer. It will also demonstrate the instrument’s utility in assembling homogeneous, heterogeneous, <strong>and</strong> cellular<br />
assays.<br />
POSTER ABSTRACTS
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