omation mbers - Society for Laboratory Automation and Screening

WP015
Diane Johnson
Pfizer Global Development and Research
Material Management
Eastern Point Road, Box 7031-10
Groton, Connecticut 06340
diane_l_johnson@groton.pfizer.com
199
Co-Author(s)
Steve Brinkman, William Heineman,
Craig Hines, Michele Kelly,
Kim Matus
Pfizer Global Research and Development Material Management Global Center of Emphasis:
Global Liquid Operations at the Groton Kings Heights Technology Center
Material Management global liquid operations focuses around a two Centers of Emphasis (CoE) model; one CoE
in Europe (Sandwich) and one CoE in the US (Kings Heights Technology Center, Groton Connecticut). The CoE
storage and distribution model optimizes liquid compound handling access, speed, and efficiency by centralizing
production functions. The Material Management-CoE model provides for redundant processing, storage and
distribution capability at two sites for all of Pfizer Global Research and Development. Vital to the success of the
CoE concept and global ordering was the adoption a uniform set of business rules and the deployment of a
global ordering platform. Groton Material Management remains committed to providing high quality compound
stewardship, storage, and processing together with corresponding data necessary to support Pfizer Global
Research and Development needs.
WP016
Mike Jones
Cambridge Antibody Technology Automation
Milstein Building, Granta Park
Cambridge, Cambridgeshire CB1 6GH United Kingdom
mike.jones@cambridgeantibody.com
Automated DNA Sequencing: Quality Not Quantity
Co-Author(s)
Richard Stevens
Kate Goode
The DNA Chemistry facility at Cambridge Antibody Technology (CAT) is responsible for sequencing 20,000
antibody fragments per month. The quality of the sequence data returned to the scientist is critical for identifying
unique antibodies for further analysis. Good quality data means that the downstream process of analysing
sequences is significantly reduced. Automated workstations have been set up to improve the efficiency and
quality of the results, and the pass rate for first time submitted sequences is 90% or greater. Automated systems
provide reproducibility through the process, along with a greatly reduced error rate than would normally be seen
if the process was done manually. Flexibility, diversity, and a short process time frame have dictated the use of a
workstation approach rather than a large fully automated system, with the same machine used for different parts
of the process. This means that if any piece of equipment is down then the process does not come to a stand still.
Here we show how we have automated DNA sequencing in the laboratory with a Tecan Genesis workstation, a
Tecan Miniprep and a Perkin Elmer Evolution P3 pipettor.
POSTER ABSTRACTS