omation mbers - Society for Laboratory Automation and Screening

TP023
Katherine Dains
Adeline Scientific
Research
1534 Plaza Lane, Suite 119
Burlingame, California 94010
kdains@earthlink.net
157
Co-Author(s)
Wensheng Chen
Information and Data Management Software for Tracking Patient, Research, and Analysis
Data in Small to Medium Clinical and Research Labs
We have developed software for information and data management for use in the small- to medium-sized life
science research labs. The system is user configurable, uncomplicated, and affordable. Most commercial data
management software products available require sophisticated IT setup, in-house personnel or outside contractors
to control and maintain the system. Our system will appeal to many laboratories that require flexibility and
specificity to their laboratory needs without the complexity and cost of a large and expensive product. At the
center of the system is a configuration tool that can be set up to handle various laboratory data management
workflows such as recruitment and tracking of research study candidates and related genetic studies. This
intelligence tool is made possible through a proprietary data model cartridge technology. After completing the
configuration process, the user can choose to deploy the data system or to merge data with existing systems. The
system is designed with three-tier architecture in the form of web applications thus allowing for easy upgrades and
remote access. Along with the simple web-based architecture, user-configurable data loading tools are provided
that will adapt to most data importing tasks. Information can be entered and tracked over long periods of time,
as well as easily retrieved through the web-based reporting structure. The system is built to support all major
database products. We will present details on the architecture, detailed design specifications, and test results from
collaborating research labs.
TP024
Juan Jose Diaz-Mochon
University of Southampton
Chemistry
Highfield Campus
Southampton SO17 1BJ United Kingdom
jjd29@soton.ac.uk
Novel PNA-Peptoid Conjugates as Antisense Drugs
Co-Author(s)
Laurent Bialy, Boon-ek Yingyongnarongkul,
Adam Belson, Mark Bradley
Peptide Nucleic Acid (PNA) has been developed in the last decade as a new DNA mimic which hybridises
complementary DNA or RNA sequences with higher affinity than its counterparts. PNA presents a 2aminoethylglycine
backbone instead of the DNA sugar-phosphonate moiety. This uncharged backbone allows
PNA to display a stronger hybridisation with DNA or RNA and to be easily synthesised. These features prompted
investigators to develop PNA analogues as promising candidates for the antisense therapy strategies. Antisense
drugs target genes that are active or over expressed in certain pathological processes thus disrupting the synthesis
of disease-responsible proteins. However, the main drawback has been their lack of cellular permeability that
has avoided their further development as efficient antisense drugs. A few promising PNA-conjugates have been
reported but new models are necessary to improve cellular permeability and overall drug-like features. Herein a
new type of PNA-conjugates with higher cellular permeability is introduced. These novel PNA oligomers are bound
to peptoids that have been reported as successful transfection agents. A library of PNA analogues has been
synthesised on solid phase using a novel deprotection strategy, and it has been tested on GFP-transfected cell
cultures. Furthermore, this library will also be tested using a cell-based microchip assay.
POSTER ABSTRACTS