Dames & Moore, 1999 - USDA Forest Service
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Dames & Moore, 1999 - USDA Forest Service

Dames & Moore, 1999 - USDA Forest Service Dames & Moore, 1999 - USDA Forest Service

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TABLE 7.1-4 TOXICITY CRITERIA AND BIOCONCENTRATION FACTORS USED FOR CALCULATION OF METHOD B LEVELS HOLDEN MINE BASELINE RISK ASSESSMENT Inhalation Inhalation Cancer Bioconcentration Oral Reference Reference Dose Potency Factor (per Parameter Factor (unitless) Source Dose (rnglkgday) Source (mgkgday) Source mglkgday) Source ......................... .- ..-............ ......... ..-..... - ......... ..... - ......... . - . .. .............. --gg&@-. ......... . , ....................... . ................................. A- ...................... Aluminum .............. 231 NCEA Suppwt Value ORNL . ! ........ ARenic 50 c-c .. _. ........ ... ... . .... ... -.I--. _ _ .. _ ........... _ " (19961 ........... Batium -. ............... loo' .............................. conservative estimate 0:OT ... - 0.OWl CLARC 1 (1986) ........ . ClARC11(]996? ..... . . ............ .- .. Beryllium 8.40 CLARC I1 (1896) ............. ............... _- _ . .. . ^ .............-..-.. -- Cadmium . .. . _ .... ................................... __ ........ . __ 6.1 CLARC 1 (1998) _. . .... -._ ......... - Chmium Vl 41.00 ........ ....... . _. .. - . -- . - . c-c l1 (I9? . . . . .- Manganese 100- Conservative estimate ... .......... . .. __ 0.047~ .... CLARC 11 (1996) .-. 0.0000143 CLARC __-_- 11 (1986) . .-..-- ....................-.... ........... Mercury, inorganic 5500 SPHEM __ 0.0000857 CLARC 1 (1996) .......... .. . . .. . _ . ...... .... . Molybdenum ....................... _ loo' ?%. . _. . $-!!! !?996! - .- -. - -- - N'Ee! . _ .-................ _- Selenium . - .................. ... . . ?:005.. ... - Uranium . . ?.a'? . e7. . . . . . . . . . . ............ .. 9.000'. . Aroda ........ 1254 - ...... O.OWO2.. ... . ___. ... ...................... 16 ...................... Conservative estimate . . . ..... ..........-.. ............. .. .... . ....... CLARC 1 (1898) -Nickel ~efinefy Dust ...................... --_ ...... -. ......... - .. - .- .......... - ............-.. ..0P . - -....-....- - .... -- .. - . SPHEM. ..-.... CLAA': !!.(1.9?! ..... - ... - -_ ............................................. 100. . . . . . . . . . cm~~Native es~mate . . . . . c-C.!1!1.?g6) -. ................................. ..... - . . . . . . .................................................. .. ....... ... ......-..... . . . . . . . . . . . . . . . . . . . . - ....... - ................. ......................... . . . . . . . . . . . . . . - !?!' ... -. ORN!- ..- E!~.!! (!M! .... - ........... ....................... ... ........................... 51286 ORNL - . ._ IS.. .. ...... . -. . .. ...... .- ...... ........ . . - .. . ..... ............................ Diesel Range Hydnxarbons . -. .. ........... - .................... .............-..-... -. .... -. ......... . - 0.001428 CIARC 1 (1kj --' . ..... -..- . - - . . . . . Noles: ORNL =Oak Ridge National Laboratory. ESIEMM-WR. 1996.. SPHEM = Supedund Public Heallh Evaluation Manual. EPA 54011-861060. 1986 NCEA = USEPA NCEA support value. IRIS = Integrated Risk Inlormation System 'A wry conservative defaull BCF of 100 was assumed 'RID adjusted downward by a fador of 3 to aocaunt for nondietary exposure as discussed in CLARCII H:Uiolden\DraM~nal nrpt\S-AHhra\Tables\7-1-(abl.ds (Table 7 14) 7/20/99 Page 1 of 1

TABLE 7.1-5 CARCINOGEN CLASSIFICATIONS AND TOXIC EFFECTS ENDPOINTS HOLDEN MINE BASELINE RISK ASSESSMENT Parameter Carcinogen Classification TO& Effedts Endpoint ._ . --- . -. ....... jwdMml§ . Aluminum Arsenic Barium A - . Skin -- - lesions --A - ..... Cardiovascular toxicity . Beryllium -.- Cadmium Calcium - Chromium III ---- - Chromium - . - -. - VI Copper _ 02 _ __ ... - 01 Nephrotoxicity -- ,pp-----.-.L. . . - - _ . - . . .... . - - - - -. - - .- . -- - . A .I_.____ ^ . -- .. D Gastrointestinal . toxicity - - ..... - Iron -. -- - - - . - - . - . Lead 82 Neurotoxicity - - - - .. . -. ...... -- Magnesium .-. Manganese D Neurotoxicity pp - - -- -- ---. - - Mercury, inorganic D Neurotoxicity, nephrotoxicity - - - . . Molybdenum Nephrotoxicity - -- . . Nickel, refinery dust A -. -. - .. Nidtel, soluble salts - .- - - - -- Weight - -- --. - . Potassium - - - -- - . - .- - ... Selenium D Clinical selenosis -- -- .- - -_ -- . - - - Silver D Skin lesions ___- __-I_ . Sodium .... 7. Thallium, soluble salts __ ... ....... Uranium, soluble salts ' Weight, nephrotoxicity ____I.__._.._____________I__ - ....-. Zinc ___ D Hernotoxicity - .. .... _ . ____ ._.I____.__._..___._II. ... _.-_- -- ...-.. -. - - -- - - -. .- -. - . - - . - - - -- -- .- -. - -- .. - -- - .- Cyanide. Total . D Weight, thyroid, neurotoxicity . - . .. .. . _..____.I/__ -. --_ -. -. - _ -- -.. - ..... -- - ..-... - .. - ... -. . - . -. ..... -- .......................... -- . -. . - - - .... Aroclor . 1016 .... . Weight .I_.__._._---.---- .. Aroclor 1221 . . .......__....__..__...___._-__._-_..___.._..._.I..__... __ ................. a , . . . . kcl lor 1232 ..._._.....__.__....__.---._I. . ... _ .. . .. .__ ... .... __ ^ ... .. . Aroclor ... 1242 _- .............. _._ ................ ..........-........ _ .... .. Aroclor __ _. _ 1248 . __ . . ._._ ..... __ .............................. . __ . Aroclor ...... 1254 .... Oculartoxicity, immunotoxicity . -. _ . . . . _..-_.I_ . ._ .......... -. ...... ........ rocl lor 1260 -. . -- .- - .. - - . - . - -- . -. ..... -- - - ..-.-.-... ..... . - .. -. ..... - .......... - ...........-..... - . .- ... PCBS, total _____ Bi I-_.-.- __ _- .......... ----. -- . _ ..... __ . ._ ._._ -. .... - .... - .- .... :-. -. . -. . .-_ -- .. ..... .- ..... ~asoline Range Hydrocarbons Diesel Range Hydrocarbons Motor Oil ........... - .. - - - - - - -- . . . . . _ ........ . . . . . . . - ... - .... - - .......... - . - . ...... ......... . .... . ...... - -. _ - .. - -. -. - .- .- - 7

TABLE 7.1-5<br />

CARCINOGEN CLASSIFICATIONS AND TOXIC EFFECTS ENDPOINTS<br />

HOLDEN MINE<br />

BASELINE RISK ASSESSMENT<br />

Parameter Carcinogen Classification<br />

TO& Effedts Endpoint<br />

._ . --- . -. .......<br />

jwdMml§<br />

.<br />

Aluminum<br />

Arsenic<br />

Barium<br />

A<br />

- .<br />

Skin<br />

-- - lesions<br />

--A - .....<br />

Cardiovascular toxicity .<br />

Beryllium<br />

-.-<br />

Cadmium<br />

Calcium -<br />

Chromium III ----<br />

-<br />

Chromium - . - -. - VI<br />

Copper<br />

_ 02 _ __ ... -<br />

01 Nephrotoxicity<br />

--<br />

,pp-----.-.L. .<br />

.<br />

- - _ . - . . .... .<br />

- - - - -. - - .- . -- - .<br />

A<br />

.I_.____ ^ . -- ..<br />

D Gastrointestinal . toxicity - - .....<br />

-<br />

Iron -. -- - - - . - - . - .<br />

Lead 82 Neurotoxicity<br />

- - - - .. . -. ......<br />

-- Magnesium<br />

.-.<br />

Manganese D Neurotoxicity<br />

pp - - -- -- ---. - -<br />

Mercury, inorganic D Neurotoxicity, nephrotoxicity - - - . .<br />

Molybdenum<br />

Nephrotoxicity<br />

- --<br />

. .<br />

Nickel, refinery dust A -. -. - ..<br />

Nidtel, soluble salts - .- - - - -- Weight - -- --. - .<br />

Potassium - - - -- - . - .- - ...<br />

Selenium D Clinical selenosis<br />

-- -- .- - -_ -- . - - -<br />

Silver D Skin lesions<br />

___- __-I_ .<br />

Sodium .... 7.<br />

Thallium, soluble salts __ ... .......<br />

Uranium, soluble salts '<br />

Weight, nephrotoxicity<br />

____I.__._.._____________I__ - ....-.<br />

Zinc ___ D Hernotoxicity - ..<br />

.... _ . ____ ._.I____.__._..___._II. ... _.-_- -- ...-..<br />

-. - - -- - - -. .- -. - . - - . - - - -- -- .- -. - -- .. - -- - .-<br />

Cyanide. Total<br />

.<br />

D Weight, thyroid, neurotoxicity . -<br />

. .. .. . _..____.I/__ -. --_<br />

-. -. - _ -- -.. - ..... -- - ..-... - .. - ... -. . - . -. ..... -- .......................... -- . -. . - - - ....<br />

Aroclor<br />

.<br />

1016<br />

.... .<br />

Weight<br />

.I_.__._._---.---- ..<br />

Aroclor 1221<br />

. . .......__....__..__...___._-__._-_..___.._..._.I..__... __ ................. a , . . . .<br />

kcl lor 1232<br />

..._._.....__.__....__.---._I. . ... _ .. . .. .__ ... .... __ ^ ... .. .<br />

Aroclor ... 1242 _- .............. _._ ................ ..........-........ _ .... ..<br />

Aroclor __ _. _ 1248<br />

. __ . . ._._ ..... __ .............................. . __ .<br />

Aroclor<br />

......<br />

1254<br />

....<br />

Oculartoxicity, immunotoxicity<br />

. -. _ . . . . _..-_.I_ . ._ .......... -. ......<br />

........ rocl lor 1260<br />

-. . -- .- - .. - - . - . - -- . -. ..... -- - - ..-.-.-... ..... . - .. -. ..... - .......... - ...........-..... - . .- ...<br />

PCBS, total _____ Bi<br />

I-_.-.- __ _-<br />

.......... ----. -- . _ ..... __ . ._ ._._ -. ....<br />

- .... - .- .... :-. -. . -. . .-_ -- .. ..... .- .....<br />

~asoline Range Hydrocarbons<br />

Diesel Range Hydrocarbons<br />

Motor Oil<br />

........... - .. - - - - - - -- .<br />

. . . . _ ........ . . . . . . .<br />

- ... - .... - - .......... - . - . ...... ......... . .... . ......<br />

- -. _ - .. - -. -. - .- .- -<br />

7

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