NCI National Clinical Trials Network (NCTN) Program Guidelines

PART 2: Submission of Competing New Applications Section I - Application Submission Instructions
photocopies in one package to the Center for Scientific Review at the address listed below. The
original must be signed by the Project Director/Principal Investigator (PD(S)/PI(S)) and an
authorized organizational or institutional official.
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD 20892-7710 (U.S. Postal Service Express or regular mail)
Bethesda, MD 20817 (for express/courier service; non-USPS service)
At the time of submission, two (2) identical, single-sided paper copies of the original application and
one (1) CD containing appendix material (if allowed for the NCTN key component) must be sent to the
address listed below. Please Note: One of the two copies of the application sent to the NCI Referral
Office may be a CD with a bookmarked PDF file (as outlined in the PHS 398). All appendix material (if
allowed for the NCTN key component) must be prepared as bookmarked PDF files on a CD following
the instructions in the PHS 398 form.
Referral Officer
Division of Extramural Activities
National Cancer Institute
6116 Executive Boulevard, Room 8041, MSC 8329
Bethesda, MD 20892-8329 (for U.S. Postal Service regular or express mail)
Rockville, MD 20852 (for non-USPS delivery)
Telephone: (301) 496-3428
FAX: (301) 402-0275
Email: ncirefof@dea.nci.nih.gov
D. Appendix Material for All Key Components of the NCTN Program
Per the NIH/NCI policy on what may be submitted as appendix materials
(http://grants.nih.gov/grants/guide/notice-files/NOT-OD-10-077.html), the information provided
below specifies if appendix materials are allowed as part of the application for the key component
of the NCTN Program as well as the type of appendix material that may be included. All appendix
materials for paper applications submitted on the PHS 398 form must be submitted as book marked
PDF files on CDs. A summary listing of all the items included in the appendix is encouraged but not
required. When including a summary, it should be the first file on the CD.
Follow the standard instructions for preparing the CDs:
� Use PDF format only. The files should prepared as PDF version no higher than 1.4 for
compatibility with NIH programs and software.
� Where possible, applicants should avoid creating PDF files from scanned documents. NIH
recommends producing the documents electronically using text or word-processing software
and then converting the document to PDF format. Scanned document images should be
checked for legibility.
� Label each disk with the date, Principal Investigator’s Name, Grant Number (if available),
grant title, and applicant institution.
� If burning CD-ROM disks on a Mac, select the ISO 9660 format.
� Do not use compression techniques for the electronic files.
� Do not use password protection, encryption, digital signature and/or digital certification in
the PDF files.
Applications for key components of the NCTN Program are scanned by central NIH offices to produce
black and white images and black and white double sided copies for the reviewers. Figures in the
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