NCI National Clinical Trials Network (NCTN) Program Guidelines

PART 4: Appendices Section IV – Cost Components for Budget Preparation for Network Group Ops
& SDMC Centers, Lead Academic Sites, & Canadian Trials Network
C. Guidelines for Estimating Type 1 Application Total Cost Budget Request for
Pediatric Network Group Operations Center and SDMC
TOTAL COST FOR PATIENT ENROLLMENT DATA/BIOSPECIMEN COLLECTION/MGT COSTS FOR PEDIATRIC NETWORK
GROUP
Total Cost Credit Value for Type 1 Application $500 $500 $500 $500 $500
"Per Case Management" Funding Category
Screening Only
(Pts screened
on study but
did not go on
to
intervention)
Biospecimens
Basic
Therapeutic
Intervention
(Including
Any Pilot/Hx
Studies)
Advanced
Imaging
Intervention
Page 213 of 241
High-
Performance
Intervention
Credit Multiplier for Category 1 1 4.5 2 8.0
Value of "Per Case Mgt" Funding Category
(Credit Value x Credit Multiplier)
$500 $500 $2,250 $1,000 $4,000
# of Patients Enrolled by Pediatric Sites - High Performance Sites 574 2800 N/A 71 2800
Total Cost "Per Case Mgt" Funding
(# Patients x Value of "Per Case Mgt" Funding)
$287,000 $1,400,000 N/A $71,000 $ 11,200,000
# of Patients Enrolled by Pediatric Sites - Other Sites 267 1300 1300 33 N/A
Total Cost "Per Case Mgt" Funding
$133,500
(# Patients x Value of "Per Case Mgt" Funding)
$650,000 $2,925,000 $33,000 N/A
Total Cost to Cover "Per Case Mgt" Funding for All Pediatric Sites By Category $420,500 $2,050,000 $2,925,000 $104,000 $ 11,200,000
Total Cost for "Per Case Mgt" Funding for All Pediatric Sites for All Categories $16,699,500
# Patients on Intervention (High-Performance, Adv Imaging, & Basic
Therapeutic) 4204
# Patients on Non-Intervention (Biospecimens & Screening) 4941
Total Cost for Financial Mgt of All Pediatric Sites for Intervention Studies
20% Used (Total Cost "Per Case Mgt" Funding for Intervention Studies x 0.20) $2,845,800
Total Cost for Financial Mgt of All Pediatric Sites for Non-Intervention Studies
10% Used (Total Cost "Per Case Mgt" Funding-Non-Intervention Studies x 0.10) $247,050
Total Cost for Scientific Leadership/Coordination at High-Performance Sites
20% Used (Total Cost "Per Case Mgt” Funding-Intervention Studies x 0.20) $2,254,200
Total Cost for Scientific Leadership/Coordination at High-Performance Sites
10% Used (Total Cost "Per Case Mgt" Funding-Non-Intervention Studies x 0.10) $168,700
Total Cost for "Per Case Mgt" Funding, Financial Mgt of All Pediatric Sites, and
Scientific Leadership/Coordination at High-Performance Sites $22,215,250
% Accrual Threshold for Pediatric High Performance Sites
% Intervention Accrual from High-Performance Sites (Therapeutic+50%
Advanced Imaging)/ All Intervention Accrual from All Sites (Therapeutic+50%
Advanced Imaging) 68.3%
Please Note: Figures in RED above denote correction to figures in Version 1.0 of the Guidelines Dated 7/23/2012 due to
$100 error in initial figures for “Screened Only” patients at High-Performance Sites ($287,100 corrected to $287,000)
and a $200 error in initial figures for “Screened Only” patients at Other Sites ($133,300 corrected to $133,500).
Budget continued on next page