HYPERTENSION MANAGEMENT AND STROKE PREVENTION ...

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54 Algorithm for Treatment of Stage 1 Hypertension (SBP 140–159 or DBP 90–99 mmHg) Thiazide-type diuretics for most. May consider ACEI, ARB, BB, CCB, or combination. Hypertension Lifestyle Modifications Not at Goal Blood Pressure (100 mmHg) 2-drug combination for most (usually thiazide-type diuretic and ACEI, or ARB, or BB, or CCB) Not at Goal Blood Pressure Optimize dosages or add additional drugs until goal blood pressure is achieved. Consider consultation with hypertension specialist. With Compelling Indications Drug(s) for the compelling indications Other antihypertensive drugs (diuretics, ACEI, ARB, BB, CCB) as needed.
55 Diuretic Use Pre- Pre and Post-ALLHAT Post ALLHAT NRxs 1,800,000 1,600,000 1,400,000 1,200,000 1,000,000 800,000 600,000 400,000 200,000 0 IMS New Prescriptions for Diuretic Sub-classes (Unallocated) Jan- 02 Feb- 02 Mar- 02 Apr- 02 May- 02 Jun- 02 Jul- 02 Aug- 02 Sep- 02 Oct- 02 No v- 02 Dec- 02 Thiazide Potassium-sparing Loop Jan- 03 Feb- 03 Mar- 03 NRxs 1,200,000 1,000,000 800,000 600,000 400,000 200,000 - Jan- 02 New Prescriptions for Chlorthalidone & Hydrochlorothiazide (Unallocated) Feb- 02 Mar- 02 Apr- 02 May- 02 Jun- 02 Jul- 02 Aug- 02 Sep- 02 Oct- 02 Nov- 02 Dec- 02 Jan- 03 CHLORTHALIDONE HYDROCHLOROTHIAZIDE Feb- 03 Mar- 03
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HYPERTENSION MANAGEMENT AND STROKE
Page 3 and 4: 3 Hypertension Treatment by Drug Cl
Page 5 and 6: 5 ALLHAT Antihypertensive Trial Des
Page 7 and 8: 7 ALLHAT Pre-Specified Outcomes All
Page 9 and 10: 9 ALLHAT Inclusion Criteria for Ant
Page 11 and 12: 11 ALLHAT ALLHAT Inclusion Criteria
Page 13 and 14: 13 ALLHAT High-risk hypertensive pa
Page 15 and 16: 15 ALLHAT Step 2 Agents: Reserpine
Page 17 and 18: 17 Cumulative Event Rate 0.30 0.25
Page 19 and 20: 19 ALLHAT 100.0 80.0 60.0 % 40.0 20
Page 21 and 22: 21 ALLHAT mm Hg BP 150 145 140 135
Page 23 and 24: 23 Percent ALLHAT 80 60 40 20 0 59
Page 25 and 26: 25 ALLHAT Cumulative Stroke Rate .1
Page 27 and 28: 27 ALLHAT Cumulative Mortality Rate
Page 29 and 30: 29 ALLHAT Total 1.04 (0.99, 1.09) A
Page 31 and 32: 31 ALLHAT Total 1.38 (1.25, 1.52) A
Page 33 and 34: 33 ALLHAT AHT: TOTAL CHD AND ALL CA
Page 35 and 36: 35 ALLHAT Antihypertensive Trial: I
Page 38 and 39: 38 ALLHAT vs. ANBP-2 • Randomized
Page 40 and 41: Primary Adjudicated Events - Ramipr
Page 42 and 43: DOES OBSERVED BP REDUCTION ACCOUNT
Page 44 and 45: Quartiles ≤124 125-139 140-150 15
Page 46 and 47: SUBGROUP RESULTS BY OTHER DRUG THER
Page 48 and 49: 48 Blood Pressure Classification BP
Page 50 and 51: 50 New Features and Key Messages
Page 52 and 53: 52 New Features and Key Messages (C
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