HYPERTENSION MANAGEMENT AND STROKE PREVENTION ...

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ALLHAT vs. ANBP-2
• Randomized double-blind vs. PROBE design
• ACEI vs. thiazide-type diuretic, n = 24,309 vs. 6,083
• Number of patients with events
– CVD: n = 6,455 vs. 823
– CHD: n = 3,956 vs. 368
– Stroke: n = 1,132 vs. 219
– Heart failure: n = 1,482 vs. 147
• Treatment differences consistent across gender
subgroup vs. differences noted only in men
• SBP slightly lower with diuretic in both trials