HYPERTENSION MANAGEMENT AND STROKE PREVENTION ...

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2 ALLHAT AHT RATIONALE • 50-60 million hypertensive patients in US • Estimated Cost: $37 billion annually • Drugs FDA approved on ability to lower BP • CCB & ACE-I shown to reduce CVD-2001 • Are they all equal-clinical outcomes/AEs? • Which drug should be used first? – Relative Efficacy-unknown – Relative Cost-known
3 Hypertension Treatment by Drug Class % of Treated Patients on Medication 60 50 40 30 20 10 0 Diuretics ß-Blocker Blocker ACE Inhibitors CCBs Calcium Channel Blockers Beta Blockers Diuretics ACE Inhibitors ARBs ARBs 1978 1981 1984 1987 1990 Year 1993 1996 1999 2002 IMS Health NDTI, 1978-2002 1978 2002
Page 1: HYPERTENSION MANAGEMENT AND STROKE
Page 5 and 6: 5 ALLHAT Antihypertensive Trial Des
Page 7 and 8: 7 ALLHAT Pre-Specified Outcomes All
Page 9 and 10: 9 ALLHAT Inclusion Criteria for Ant
Page 11 and 12: 11 ALLHAT ALLHAT Inclusion Criteria
Page 13 and 14: 13 ALLHAT High-risk hypertensive pa
Page 15 and 16: 15 ALLHAT Step 2 Agents: Reserpine
Page 17 and 18: 17 Cumulative Event Rate 0.30 0.25
Page 19 and 20: 19 ALLHAT 100.0 80.0 60.0 % 40.0 20
Page 21 and 22: 21 ALLHAT mm Hg BP 150 145 140 135
Page 23 and 24: 23 Percent ALLHAT 80 60 40 20 0 59
Page 25 and 26: 25 ALLHAT Cumulative Stroke Rate .1
Page 27 and 28: 27 ALLHAT Cumulative Mortality Rate
Page 29 and 30: 29 ALLHAT Total 1.04 (0.99, 1.09) A
Page 31 and 32: 31 ALLHAT Total 1.38 (1.25, 1.52) A
Page 33 and 34: 33 ALLHAT AHT: TOTAL CHD AND ALL CA
Page 35 and 36: 35 ALLHAT Antihypertensive Trial: I
Page 38 and 39: 38 ALLHAT vs. ANBP-2 • Randomized
Page 40 and 41: Primary Adjudicated Events - Ramipr
Page 42 and 43: DOES OBSERVED BP REDUCTION ACCOUNT
Page 44 and 45: Quartiles ≤124 125-139 140-150 15
Page 46 and 47: SUBGROUP RESULTS BY OTHER DRUG THER
Page 48 and 49: 48 Blood Pressure Classification BP
Page 50 and 51: 50 New Features and Key Messages
Page 52 and 53:
52 New Features and Key Messages (C
Page 54 and 55:
54 Algorithm for Treatment of Stage
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