HYPERTENSION MANAGEMENT AND STROKE PREVENTION ...
HYPERTENSION MANAGEMENT AND STROKE PREVENTION ... HYPERTENSION MANAGEMENT AND STROKE PREVENTION ...
20 ALLHAT Percent 100 80 60 40 20 0 Use of Blinded (Step 1) Drug and Number of Antihypertensive Drugs Prescribed On 1 Drug On 2 Drugs On 3 Drugs On Step 1 Drug 0 12 24 36 48 60 Months of Follow-Up @ 5 years: 62% were on >2 2 drugs 30% were on 1 drug with BP
21 ALLHAT mm Hg BP 150 145 140 135 130 Chlorthalidone Amlodipine Lisinopril 0 1 2 3 4 5 6 Years Compared to chlorthalidone: SBP significantly higher in the amlodipine group (~1 mm Hg) and the lisinopril group (~2 mm Hg). BP Results by Treatment Group mm Hg BP 90 85 80 75 70 0 1 2 3 4 5 6 Years Compared to chlorthalidone: DBP significantly lower in the amlodipine group (~1 mm Hg).
- Page 1 and 2: HYPERTENSION MANAGEMENT AND STROKE
- Page 3 and 4: 3 Hypertension Treatment by Drug Cl
- Page 5 and 6: 5 ALLHAT Antihypertensive Trial Des
- Page 7 and 8: 7 ALLHAT Pre-Specified Outcomes All
- Page 9 and 10: 9 ALLHAT Inclusion Criteria for Ant
- Page 11 and 12: 11 ALLHAT ALLHAT Inclusion Criteria
- Page 13 and 14: 13 ALLHAT High-risk hypertensive pa
- Page 15 and 16: 15 ALLHAT Step 2 Agents: Reserpine
- Page 17 and 18: 17 Cumulative Event Rate 0.30 0.25
- Page 19: 19 ALLHAT 100.0 80.0 60.0 % 40.0 20
- Page 23 and 24: 23 Percent ALLHAT 80 60 40 20 0 59
- Page 25 and 26: 25 ALLHAT Cumulative Stroke Rate .1
- Page 27 and 28: 27 ALLHAT Cumulative Mortality Rate
- Page 29 and 30: 29 ALLHAT Total 1.04 (0.99, 1.09) A
- Page 31 and 32: 31 ALLHAT Total 1.38 (1.25, 1.52) A
- Page 33 and 34: 33 ALLHAT AHT: TOTAL CHD AND ALL CA
- Page 35 and 36: 35 ALLHAT Antihypertensive Trial: I
- Page 38 and 39: 38 ALLHAT vs. ANBP-2 • Randomized
- Page 40 and 41: Primary Adjudicated Events - Ramipr
- Page 42 and 43: DOES OBSERVED BP REDUCTION ACCOUNT
- Page 44 and 45: Quartiles ≤124 125-139 140-150 15
- Page 46 and 47: SUBGROUP RESULTS BY OTHER DRUG THER
- Page 48 and 49: 48 Blood Pressure Classification BP
- Page 50 and 51: 50 New Features and Key Messages
- Page 52 and 53: 52 New Features and Key Messages (C
- Page 54 and 55: 54 Algorithm for Treatment of Stage
21<br />
ALLHAT<br />
mm Hg BP<br />
150<br />
145<br />
140<br />
135<br />
130<br />
Chlorthalidone Amlodipine Lisinopril<br />
0 1 2 3 4 5 6<br />
Years<br />
Compared to chlorthalidone:<br />
SBP significantly higher in the<br />
amlodipine group (~1 mm Hg) and<br />
the lisinopril group (~2 mm Hg).<br />
BP Results by Treatment Group<br />
mm Hg BP<br />
90<br />
85<br />
80<br />
75<br />
70<br />
0 1 2 3 4 5 6<br />
Years<br />
Compared to chlorthalidone:<br />
DBP significantly lower in the<br />
amlodipine group (~1 mm Hg).
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