Klaas Martinus Pos Publications 2006-2012 - CEF-MC
Klaas Martinus Pos Publications 2006-2012 - CEF-MC
Klaas Martinus Pos Publications 2006-2012 - CEF-MC
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<strong>Klaas</strong> <strong>Martinus</strong> <strong>Pos</strong><br />
<strong>Publications</strong> <strong>2006</strong>-<strong>2012</strong><br />
(last updated 09/<strong>2012</strong>)<br />
Bohnert JA, Schuster S, Seeger MA, Fahnrich E, <strong>Pos</strong> KM, Kern WV (2008) Site-directed mutagenesis<br />
reveals putative substrate binding residues in the Escherichia coli RND efflux pump AcrB. J Bacteriol<br />
190:8225-8229<br />
Brandstatter L, Sokolova L, Eicher T, Seeger MA, Briand C, Cha HJ, Cernescu M, Bohnert J, Kern<br />
WV, Brutschy B, <strong>Pos</strong> KM (2011) Analysis of AcrB and AcrB/DARPin ligand complexes by LILBID MS.<br />
BBA-Biomembranes 1808:2189-2196<br />
Camargo SMR, Singer D, Makrides V, Huggel K, <strong>Pos</strong> KM, Wagner CA, Kuba K, Danilczyk U, Skovby<br />
F, Kleta R, Penninger JM, Verrey F (2009) Tissue-specific amino acid transporter partners ACE2 and<br />
collectrin differentially interact with hartnup mutations. Gastroenterology 136:872-882<br />
Eicher T, Cha HJ, Seeger MA, Brandstatter L, El-Delik J, Bohnert JA, Kern WV, Verrey F, Grutter MG,<br />
Diederichs K, <strong>Pos</strong> KM (<strong>2012</strong>) Transport of drugs by the multidrug transporter AcrB involves an access<br />
and a deep binding pocket that are separated by a switch-loop. P Natl Acad Sci USA 109:5687-92<br />
Furrer EM, Ronchetti MF, Verrey F, <strong>Pos</strong> KM (2007) Functional characterization of a NapA Na+/H+<br />
antiporter from Thermus thermophilus. FEBS Lett 581:572-578<br />
Gauntlett JC, Gebhard S, Keis S, Manson JM, <strong>Pos</strong> KM, Cook GM (2008) Molecular analysis of BcrR,<br />
a membrane-bound bacitracin sensor and DNA-binding protein from Enterococcus faecalis. J Biol<br />
Chem 283:8591-8600<br />
Oberfeld B, Ruffieux-Daidie D, Vitagliano JJ, <strong>Pos</strong> KM, Verrey F, Staub O (2011) Ubiquitin-specific<br />
protease 2-45 (Usp2-45) binds to epithelial Na(+) channel (ENaC)-ubiquitylating enzyme Nedd4-2. Am<br />
J Physiol-Renal Physiol 301:F189-F196<br />
Oswald C, <strong>Pos</strong> KM (2011) Drug resistance: A periplasmic ménage à trois. Chem Biol 18:405-407<br />
Pietras Z, Lin HT, Surade S, Luisi B, Slattery O, <strong>Pos</strong> KM, Moreno A (2010) The use of novel organic<br />
gels and hydrogels in protein crystallization. J Appl Crystallogr 43:58-63<br />
<strong>Pos</strong> KM (2009) Drug transport mechanism of the AcrB efflux pump. BBA-Proteins Proteom 1794:782-<br />
793<br />
Ramadan T, Camargo SMR, Herzog B, Bordin M, <strong>Pos</strong> KM, Verrey F (2007) Recycling of aromatic<br />
amino acids via TAT1 allows efflux of neutral amino acids via LAT2-4F2hc exchanger. Pflug Arch Eur<br />
J Phy 454:507-516<br />
Ramadan T, Camargo SMR, Summa V, Hunziker P, Chesnov S, <strong>Pos</strong> KM, Verrey F (<strong>2006</strong>) Basolateral<br />
aromatic amino acid transporter TAT1 (Slc16A10) functions as an efflux pathway. J Cell Physiol<br />
206:771-779<br />
Reimer D, <strong>Pos</strong> KM, Thines M, Grun P, Bode HB (2011) A natural prodrug activation mechanism in<br />
nonribosomal peptide synthesis. Nat Chem Biol 7:888-890<br />
Seeger MA, Diederichs K, Eicher T, Brandstatter L, Schiefner A, Verrey F, <strong>Pos</strong> KM (2008) The AcrB<br />
efflux pump: Conformational cycling and peristalsis lead to multidrug resistance. Curr Drug Targets<br />
9:729-749<br />
Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, <strong>Pos</strong> KM (<strong>2006</strong>) Structural asymmetry of<br />
AcrB trimer suggests a peristaltic pump mechanism. Science 313:1295-1298<br />
Seeger MA, von Ballmoos C, Eicher T, Brandstatter L, Verrey F, Diederichs K, <strong>Pos</strong> KM (2008)<br />
Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB.<br />
Nat Struct Mol Biol 15:199-205
Seeger MA, von Ballmoos C, Verrey F, <strong>Pos</strong> KM (2009) Crucial role of Asp408 in the proton<br />
translocation pathway of multidrug transporter AcrB: Evidence from site-directed mutagenesis and<br />
carbodiimide labeling. Biochemistry 48:5801-5812<br />
Vargiu AV, Collu F, Schulz R, <strong>Pos</strong> KM, Zacharias M, Kleinekathofer U, Ruggerone P (2011) Effect of<br />
the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by<br />
molecular dynamics simulations. J Am Chem Soc 133:10704-10707