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Fiflow® BTX<br />
<strong>Liquid</strong> <strong>Surgery</strong> <strong>Without</strong> <strong>Scars</strong><br />
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Biochemistry along with photographic tricks of “Soft Focus”<br />
are traditionally used in cosmetics as methods to soften the<br />
signs of wrinkle appearance.<br />
So far most anti-wrinkle products give weak results, and most<br />
biochemical compounds simply don’t satisfy the consumers,<br />
as they very often change to use a different product<br />
without committing to any of them long term. Consumers<br />
are looking for immediate signs of skin improvement, as<br />
well as permanent amelioration in skin structure with<br />
disappearance of age lines.<br />
To obtain good visible results, many women and men<br />
have decided to use more efficient methods than topical<br />
applications, leading to a dramatic increase of the number of<br />
face surgeries. However, they are not without risks, and need<br />
to be renewed frequently to maintain the young look.<br />
The trend today is to postpone surgeries as much as possible<br />
and use softer efficient methods to reduce wrinkles. Today<br />
FDA has approved BOTOX® Cosmetics as an aesthetic<br />
treatment to temporarily improve the appearance of<br />
glabellar lines by targeting the muscles that cause them with<br />
local injections.<br />
BOTOX® Cosmetics is not without risks either. BOTOX®<br />
(Botulinum toxin) is a toxin and can be potent in high<br />
concentration. Only small, diluted amounts of BOTOX®<br />
are used in treatments to reduce facial wrinkles. The most<br />
common side effects are headache and temporary redness<br />
or bruising of the skin. There is a chance that non-targeted<br />
muscles could be affected and weakened. This could cause<br />
drooping of the eyelid if BOTOX® seeps below the eyebrow<br />
and into the muscle that controls eyelid function. The effect<br />
is not permanent, but can be found most disturbing, as it<br />
only goes away as BOTOX® wears off, in about 5-6 months.<br />
We were inspired to create even an easier solutions than<br />
BOTOX® Cosmetics with high efficiency and user friendly<br />
usage. Fiflow® BTX is a raw material, which in cosmetic<br />
formulations acts in multiple levels imparting BOTOX®-like<br />
effects without surgeries, injections or unwanted side effects.<br />
Fiflow® BTX<br />
Fiflow® BTX<br />
Fiflow® BTX is based on a blend of medical grade<br />
perfluorocarbons (PFC), which are not drugs, as they only act<br />
as gas carriers. The performance of Fiflow® BTX is based on<br />
four mechanisms permitting strong and fast visible results,<br />
and more importantly, long term improvement of age lines.<br />
First mechanism: very fast penetration of the dermis and<br />
long half-life with different molecular weights. An old trick<br />
in cosmetic formulations is to use esters or oils, which<br />
penetrate quickly and instantaneously reduce the wrinkles.<br />
As they have small molecular weights, they increase the lipid<br />
content of the skin, increasing the volume of the dermis. This<br />
effect does not last long, as esters penetrate quickly to the<br />
deeper skin levels, retransforming the dermis volume back<br />
to normal. Fiflow® BTX is developed based on a combination<br />
of PFCs with variable molecular weighths and half-lives, to<br />
maximise the acting time in the dermis. Low molecular weight<br />
PFCs penetrate quickly allowing immediate visible results.<br />
High molecular weight PFCs penetrate slower maintaining<br />
the initial results and further treating the dermis. The halflive<br />
of a Fiflow® BTX is eleven days, which is the time how<br />
long the results can last after stopping the application.<br />
Second mechanism: instant skin volume increase based on<br />
volume structure of PFCs and their omniphobic properties.<br />
PFCs are not watersoluble nor oil soluble materials, hence<br />
called omniphobic. The inclusion of them in the intercellular<br />
cement, which is constituted from water, phospholipids and<br />
lipids as lamellar flat 2D liquid crystals, creates volume by 3D<br />
hexagonal micelle structure. This phenomena is comparable<br />
to ice versus water; ice is structured, volumised water. Based<br />
on skin surface studies, Fiflow® BTX increases the volume of<br />
dermis by 10 –15%, reducing the appearance of fine lines.<br />
Third mechanism: BOTOX®-type strong muscular relaxation.<br />
Deep wrinkles in the facial area are due to muscular effect,<br />
as the muscles get tense and shorten due to small electrical<br />
impulses. This can be reduced with insulating the muscles<br />
from electrical forces by dielectrics. Fiflow® BTX is a<br />
dielectric, and when used as a topical application, it will allow<br />
the glabellar muscles to relax and let them to find the natural<br />
position. This will immediately improve the skin appearance<br />
and reduce the wrinkles, which can be easily demonstrated<br />
by half-face tests.<br />
Number and depth of wrinkles decreases dramatically after 28-day Fiflow® BTX treatment.
Fourth mechanism: cell cleaning from Carbon Dioxide<br />
refreshing the cellular metabolism. Skin’s uptake of Oxygen<br />
starts to decline at age of 20 and is reduced by 50 % by<br />
age of 50.<br />
Oxygen is compulsory to the skin. Urban pollutions have<br />
lowered the overall level of oxygen in the environment<br />
to ca. 21%. This level is about half of what the air use to<br />
contain. Further, the skin is the last organ where inhaled<br />
oxygen travels, because oxygen depletion of the skin is not<br />
as detrimental as to other organs. Oxygen depletion and<br />
Carbon Dioxide accumulation lead to poor cell respiration<br />
which causes dehydration, uneven skin tone and dull skin. It<br />
is probably the largest contributor to the pre-mature aging<br />
of the skin, as Carbon Dioxide hinders or stops bio-pathways<br />
for cell metabolism.<br />
PFCs are the best gas carriers known to science. Fiflow® BTX<br />
can solubilise Oxygen and Carbon Dioxide, mimicking the<br />
function of hemoglobin. Fiflow® BTX carries Oxygen into the<br />
dermis, where it will diffuse from a region of higher partial<br />
O2 pressure to a region of lower partial O2 pressure. As<br />
Carbon Dioxide is more soluble in Fiflow® BTX than Oxygen,<br />
it will immediately replace Oxygen in Fiflow® BTX and will<br />
be carried out by it. This will allow cells to breathe normally<br />
and refresh their biological functions, leading to much better<br />
skin appearance. In medical world, pre-matured babies are<br />
saved thanks to PFCs, as in liquid breathing Oxygen is carried<br />
by PFCs to their brains and permanent damages are avoided.<br />
Efficacy Testing<br />
The Oxygen carrying capacity is directly comparable to<br />
the concentration of PFC used. The more PFCs are used in<br />
the cosmetic formula, the more Oxygen can be found in<br />
the skin. The Oxygen content of the skin can be measured<br />
transcutaneously by the means of polarizable probe by an<br />
Oxymonitor, results presented in the graph.<br />
Images of skin topography analyses before and after Fiflow® BTX<br />
treatment. Skin volumising effect 10-15% after 7 days treatment.<br />
A 14 day panel test was made with 30 women, aged 35-40<br />
years with visible wrinkles around eyes. An emulsion with<br />
10% Fiflow® BTX was applied twice a day for one week. After<br />
seven days the treatment was finished and the moisture<br />
of the skin was measured, as well as the skin profile was<br />
analysed. The moisture content was increased gradually<br />
during the period, reaching 52% increase. The moisture<br />
content remains at high level for eleven days, which is the<br />
half-life of Fiflow® BTX.<br />
The skin topography analyses were made to analyse the<br />
efficiency of Fiflow® BTX. The evolution of the skin surface<br />
during anti-aging treatment is determined by comparition<br />
relief parameters obtained by the shadow casting method.<br />
The number of wrinkles, depth of the wrinkles and the length<br />
of the wrinkles were analysed and as a results a 10-50%<br />
increase in volume was found after seven days topical<br />
treatment of 10% Fiflow® BTX.<br />
3D structure of Fiflow® BTX<br />
Oxygen contents found in the dermis<br />
as a function of quantity of PFC
©2004<br />
Technical properties<br />
Fiflow® BTX is transparent, highly volatile liquid, which<br />
carriers gases, penetrates quickly in the skin, forms an<br />
incredible soft film, which can be sensed hours after<br />
application. The density of Fiflow® BTX is very high and if it<br />
is used in very low viscosity bases, it can sink to the bottom.<br />
A quick shake will instantly re-emulsify it and disperse it<br />
homogeniously in the product, as bi-phase products do.<br />
Fiflow® BTX and Gases<br />
PFCs always carry gases, which in normal conditions is air.<br />
They can specifically be enriched with some gases, like Oxygen<br />
and Nitrogen. We offer Fiflow® BTX also loaded with Oxygen<br />
and we can measure the exact value of solubilised Oxygen<br />
with the Oxygen meter. Oxygen loading is necessary to obtain<br />
most efficient results, but as air contains 21% Oxygen, Fiflow®<br />
BTX naturally acts as an Oxygen carrier. Nitrogen loading<br />
can be a solution for products, which are Oxygen sensitive to<br />
create an inert atmosphere. Then, of course, the air in Fiflow®<br />
BTX has to be replaced completely by Nitrogen.<br />
Gas loaded Fiflow® BTX requires a special, hermetic packaging<br />
with a pump. If this type of packaging is not used, the<br />
Oxygen level will go down slowly but surely, and Oxygen will<br />
be replaced by air. Also this phenomena has to be considered<br />
in the production. Oxygen loaded Fiflow® BTX has to be<br />
added in the emulsion in the end when cooled down, like<br />
fragrances. The vessel should be covered immediately to avoid<br />
unnecessary Oxygen loss and packed as soon as possible.<br />
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Cosmetics Innovations and Technologies Sarl<br />
Fiflow® BTX in formulations<br />
Formulating with Fiflow® BTX is extremely easy. It can be<br />
mixed into the emulsion base directly at cool temperature<br />
to avoid evaporation. No preparative actions are necessary.<br />
Fiflow® BTX forms instantly a third phase in any emulsion,<br />
as it is a completely insoluble material. It is very inert and<br />
compatible with all cosmetic raw materials. Fiflow® BTX is<br />
safe and does not cause any sensitation or allergic reactions.<br />
Fiflow® BTX can be used in emulsions, gels and even in<br />
transparent emulsions, in skin care and colour care. As<br />
technical service we offer formulations for anti-age and antiwrinkle<br />
products for serums, neck products, masks, water<br />
free emulsions, etc. An interesting new consumer group is<br />
men, who look for solutions for younger looks in comfortable<br />
and easy to use products.<br />
Fiflow® BTX offers a mechanism, which has been proven to<br />
work by many medical applications. Easy to understand and<br />
even easier to use.<br />
INCI Name: Perfluorohexane (and)<br />
Perfluoroperhydrophenanthrene (and) Perfluorodecalin<br />
JCIC: Perfluoropolyether<br />
Typical use level: 5-20%.<br />
6 rue Jules Pasdeloup • 28109 Dreux Cedex • FRANCE<br />
www.creationscouleurs.com info@creationscouleurs.com<br />
+33 (0)2 37 42 18 34
Fiflow® BTX Cream at 10%(N° 1904-2/2005)<br />
Panel test on 4 females<br />
Applicaton of the Fiflow® BTX cream for eye area on four females, ages 53, 46, 35 and 28.<br />
The photos were taken just before application and 90 seconds after application.<br />
53 years, before 53 years, after<br />
46 years, before * 46 years, after *<br />
35 years, before 35 years, after
28 years, before 28 years, after<br />
Long term effects on using Fiflow® BTX Cream at 10% level<br />
Test started 9/2005 Test finished 3/2007<br />
The Fiflow® BTX Cream product was applied once a day, every day during 18 moths. A significant<br />
improvement of skin structure can be seen. The test person is a 45 year old female,<br />
who uses only Fiflow® BTX Cream.<br />
Note: the 46 year-old woman uses the tested cream daily. The photos show the imme-<br />
diate and the long-term effect of the cream on the 46-year-old woman.