2 - TI Pharma

Chapter 2 Glucocorticoids: metabolic side effects
104. Hamamdzic D, Duzic E, Sherlock jD, Lanier SM. Regulation of alpha 2-adrenergic receptor expression
48
and signaling in pancreatic beta-cells. Am J Physiol 1995;269(1Pt 1):E162-71.
105. Philippe j, Missotten M. Dexamethasone inhibits insulin biosynthesis by destabilizing insulin
messenger ribonucleic acid in hamster insulinoma cells. Endocrinology. 1990;127(4):1640-5.
106. Ranta F, Avram D, Berchtold S, Dufer M, Drews G, Lang F, Ullrich S. Dexamethasone induces cell death
in insulin-secreting cells, an effect reversed by exendin-4. Diabetes. 2006;55(5):1380-90.
107. Longano CA, Fletcher HP. Insulin release after acute hydrocortisone treatment in mice. Metabolism.
1983;32(6):603-8.
108. Wang ZL, Bennet WM, Wang RM, Ghatei MA, Bloom SR. Evidence of a paracrine role of neuropeptide-Y
in the regulation of insulin release from pancreatic islets of normal and dexamethasone-treated rats.
Endocrinology. 1994;135(1):200-6.
109. Mulder H, Ahren B, Stridsberg M, Sundler F. Non-parallelism of islet amyloid polypeptide (amylin)
and insulin gene expression in rats islets following dexamethasone treatment. Diabetologia.
1995;38(4):395-402.
110. Ohneda M, johnson jH, Inman LR, Unger RH. GLUT-2 function in glucose-unresponsive beta cells of
dexamethasone-induced diabetes in rats. j Clin Invest. 1993;92(4):1950-6.
111. Grill V, Rundfeldt M. Abnormalities of insulin responses after ambient and previous exposure to
glucose in streptozocin-diabetic and dexamethasone-treated rats. Role of hyperglycemia and
increased B-cell demands. Diabetes. 1986;35(1):44-51.
112. Delaunay F, Khan A, Cintra A, Davani B, Ling ZC, Andersson A, Ostenson CG, Gustafsson j, Efendic S,
Okret S. Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids. j
Clin Invest. 1997;100(8):2094-8.
113. Davani B, Portwood N, Bryzgalova G, Reimer MK, Heiden T, Ostenson CG, Okret S, Ahren B, Efendic
S, Khan A. Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic beta-cells
develop diabetes. Diabetes. 2004;53 Suppl 1:S51-9.
114. Kalhan SC, Adam PA. Inhibitory effect of prednisone on insulin secretion in man: model for
duplication of blood glucose concentration. j Clin Endocrinol Metab. 1975;41(3):600-10.
115. Van Raalte DH, Mari A, Bunck MC, Nofrate V, Dokter W, Nassander U et al. Acute and 2-week exposure
to prednisolone impair different aspects of beta-cell function in healthy men. Eur j Endocrinol.
2010;162(4):729-35.
116. Beard jC, Halter jB, Best jD, Pfeifer MA, Porte D, jr. Dexamethasone-induced insulin resistance
enhances B cell responsiveness to glucose level in normal men. Am j Physiol. 1984;247(5 Pt
1):E592-6.
117. Grill V, Pigon j, Hartling SG, Binder C, Efendic S. Effects of dexamethasone on glucose-induced insulin
and proinsulin release in low and high insulin responders. Metabolism. 1990;39(3):251-8.