2 - TI Pharma

Supplementary Table 2. Metabolic parameters during the two-step hyperinsulinemic-euglycemic clamp
before and during two-week treatment with placebo, prednisolone 7.5 mg or prednisolone 30 mg.
Glucose step 1
(mmol/l)
Glucose step 2
(mmol/l)
Insulin step 1
(pmol/l)
Insulin step 2
(pmol/l)
Glucagon step 1
(pmol/l)
Glucagon step 2
(pmol/l)
NEFA step 1
(mmol/l)
NEFA step 2
(mmol/l)
Pre-treatment On-treatment P1 P2 P3
PLB 5.0±0.1 5.0±0.2
7.5 4.9±0.1 4.9±0.2
0.389 NA NA
30 5.0±0.2 5.0±0.1
PLB 5.1±0.2 5.1±0.2
7.5 5.1±0.2 5.0±0.1
0.860 NA NA
30 5.0±0.2 5.0±0.2
PLB 172±36 179±35
7.5 171±26 161±32
0.398 NA NA
30 165±33 151±39
PLB 529±74 571±102
7.5 531±73 522±81
0.055 NA NA
30 497±86 481±105
PLB 41±8 36±5
7.5 48±6 52±13
0.016 0.232 0.02
30 38±9 58±20
PLB 31±8 32±7
7.5 35±8 41±12
0.156 NA NA
30 32±8 44±15
PLB 0.03 (0.02-0.04) 0.03 (0.02-0.04)
7.5 0.03 (0.02-0.05) 0.05 (0.04-0.1) < 0.0001 0.034 0.0002
30 0.02 (0.02-0.03) 0.12 (0.09-0.16)
PLB