2 - TI Pharma

Supplementary Figure 3. Kinetic equations for the steady-state (a) and for the non-steady state (b).
Where: R a = rate of appearance; TTR tracer = tracer/tracee ratio of the tracer infused (=1); I tracer = tracer
infusion rate; TTR p = tracer/tracee ratio in plasma; TTR exo = tracer/tracee ratio of exogenous glucose
infusion; I exo : infusion rate of exogenous glucose; R d = rate of disappearance; R a (t)= average R a between t=1
and t=2; TTR p (t)= average TTR p between t=1 and t=2; pV= distribution volume; C unl (t)= average plasma
concentration tracee between t=1 and t=2; dTTR p (t)/dt = change in plasma TTR p between t=1 and t=2;
R d (t) = average R d between t=1 and t=2; dC unl (t)/dt = change in tracee concentration between t=1 and t=2;
EP(t) = average endogenous production between t=1 and t=2; I unl = tracee infusion rate.
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Chapter 8