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44. Schakman O, Gilson H, Thissen jP. Mechanisms of glucocorticoid-induced myopathy. j Endocrinol. 2008;197(1):1-10. 45. Dessein PH, joffe BI. Insulin resistance and impaired beta cell function in rheumatoid arthritis. Arthritis Rheum. 2006;54(9):2765-75. 46. Willi SM, Kennedy A, Wallace P, Ganaway E, Rogers NL, Garvey WT. Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin. Diabetes. 2002;51(10):2895-902. 47. Rosen j, Miner jN. The search for safer glucocorticoid receptor ligands. Endocr Rev 2005;26(3):452- 64. 169 8 Chapter 8
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Diabetogenic Effects of Glucocortic
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VRIjE UNIVERSITEIT Diabetogenic Eff
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Leescommissie: prof.dr. M. Boers pr
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Chapter 12 Angiopoietine-like prote
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Chapter 1 General Introduction and
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Figure 1. Overview of the therapeut
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inding to the intracellular GR, fol
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further explored the effects of bot
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17. Kaplan SA, Shimizu CS. Effects
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Chapter 2 Novel Insights into Gluco
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1. INTRoDUCTIoN Glucocorticoid (GC)
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which GCs enhance gene transcriptio
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after GC-treatment has been propose
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oral), the vulnerability of the pop
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4.2. Glucocorticoids modulate adipo
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metabolism by reducing the expressi
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At older age, these mice developed
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mice with adipose tissue-specific 1
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REFERENCES 1. McMahon M, Gerich j,
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31. Henriksen jE, Alford F, Vaag A,
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60. Opherk C, Tronche F, Kellendonk
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89. Seckl jR, Morton NM, Chapman KE
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118. Matsumoto K, Yamasaki H, Akaza
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PART Glucocorticoids and islet-cell
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Chapter 3 Glucocorticoids induce be
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Chapter 4 Glucocorticoids impair be
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Chapter 5 Glucocorticoids, islet-ce
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Chapter 6 Glucocorticoid receptor S
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Chapter 7 Glucagon-Like Peptide-1 R
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Glucocorticoids (GCs) are diabetoge
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glucagon, acetaminophen and exenati
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C-peptide (AUC CP ) tended to be lo
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Figure 2. The effect of prednisolon
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Page 290: REFERENCES 1. van Raalte DH, Ouwens
Page 294: SUPPLEMENTAL FIGURES Supplemental F
Page 302: Chapter 8 Low-dose Glucocorticoid T
Page 306: Glucocorticoids (GCs) are the corne
Page 310: Experimental protocol - clamp: Afte
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Page 318: Lipid Metabolism: Lipolysis in the
Page 322: Figure 3. The effect of prednisolon
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Page 350: Chapter 9 Glycosphingolipid Metabol
Page 354: INTRoDUCTIoN Glucocorticoids (GCs)
Page 358: Experimental protocol: The design o
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Page 366: Table 3. Mitochondrial respiration
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prednisolone 30 mg group, and the c
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REFERENCES 1. Schacke H, Docke WD,
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29. Kabayama K, Sato T, Saito K, Lo
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Chapter 10 Glucocorticoid Treatment
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Glucocorticoids (GCs) represent the
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capillary recruitment. Capillary re
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elatively small numbers in each gro
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Table 2. Metabolic parameters and b
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Table 3. Capillary density before a
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Prednisolone and insulin signaling
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DISCUSSIoN This is the first study
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glucose uptake suggesting that the
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15. de jongh RT, Serne EH, RG Ij, d
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SUPPLEMENTARy MATERIAL Supplemental
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Chapter 11 Glucocorticoids alter Su
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Glucocorticoids (GCs) are important
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Adipose tissue was washed with ster
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Figure 1. Effects of glucocorticoid
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Impaired insulin action in adipose
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REFERENCES 1. van Raalte DH, Ouwens
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30. Ouchi N, Parker JL, Lugus JJ, W
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Chapter 12 Angptl4 in glucocorticoi
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PART Metabolic Effects of Glucocort
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Chapter 13 Glucocorticoids in acute
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Chapter 14 Glucose Tolerance, Insul
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INTRoDUCTIoN Rheumatoid arthritis (
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independent ethics committee approv
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Glucose tolerance state: The preval
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Data represent means ± standard de
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**** Number of DMARDs (both synthet
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Effect modification: As compared to
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described here, may even be underes
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15. Wolfe F, Michaud K. Corticoster
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PART Discussion V
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Chapter 15 General Discussion Gluco
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Chapter 15 General Discussion Studi
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Chapter 15 General Discussion Figur
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Chapter 15 General Discussion AMP-a
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Chapter 15 General Discussion shown
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Chapter 15 General Discussion decre
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Chapter 15 General Discussion Inter
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Chapter 15 General Discussion Mecha
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Chapter 15 General Discussion and a
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Chapter 15 General Discussion and p
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Chapter 15 General Discussion short
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Chapter 15 General Discussion Table
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Chapter 15 General Discussion REFER
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Chapter 15 General Discussion 30. S
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Chapter 15 General Discussion 58. L
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Chapter 15 General Discussion 88. F
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Chapter 15 General Discussion 119.
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Nederlandse Samenvatting Diabetogen
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het bleek ook heel effectief bij de
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door prednisolon behandeling. In di
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In deel 4 van mijn proefschrift bes
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Dankwoord Acknowledgements
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Geachte Dr. Ouwens, beste Margriet.
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Dr. Kersten, beste Sander, veel dan
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Biography
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Daniël Henri van Raalte was born o
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List of Publications 1. van Genugte
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List of Publications 20. van Raalte
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List of co-author affiliations Andr
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List of co-author affiliations Jos
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List of co-author affiliations Timo
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Color Figures Chapter 1 Figure 1. O
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