2 - TI Pharma

Figure 3. The effect of prednisolone treatment on protein metabolism. a Valine turnover in the basal state,
was not affected by prednisolone treatment. b Overall, valine turnover was increased during step 1 of
the hyperinsulinemic-euglycemic clamp by prednisolone treatment. This seemed driven by prednisolone
30 mg in post-hoc analysis, but failed to reach statistical significance. c A similar pattern was observed
during step 2 of the clamp, where overall prednisolone treatment increased valine turnover, however
in post-hoc testing, no significance was reached for either dose as compared to placebo. Data represent
mean ± SEM. Black bars, before treatment; white bars, day 14 of treatment. Between-group changes from
baseline were tested by Kruskal-Wallis (indicated by top line). Posthoc tests were done by Mann-Whitney
U with Bonferroni correction for multiple testing (indicated by line with brackets). *P