2 - TI Pharma

More documents

Recommendations

Info

Chapter 5 Glucocorticoids, islet-cell function & ANS We conclude that, in addition to reducing insulin sensitivity, prolonged prednisolone treatment dose-dependently impairs islet-cell function in healthy males. Our data furthermore suggest that changes in ANS balance may contribute to these GC-related changes. Funding: This paper was written within the framework of the Dutch Top Institute <strong>Pharma</strong> T1.106. Drs. Renate van Genugten is supported by the EFSD/MSD Clinical Research Programme 2008. The authors thank dr. M.W. Heymans of the department of Epidemiology and Biostatistics of the VU University Medical Center for his help with the statistical analyses. 106
Page 2:
Diabetogenic Effects of Glucocortic
Page 6:
VRIjE UNIVERSITEIT Diabetogenic Eff
Page 10:
Leescommissie: prof.dr. M. Boers pr
Page 14:
Chapter 12 Angiopoietine-like prote
Page 22:
Chapter 1 General Introduction and
Page 26:
Figure 1. Overview of the therapeut
Page 30:
inding to the intracellular GR, fol
Page 34:
further explored the effects of bot
Page 38:
17. Kaplan SA, Shimizu CS. Effects
Page 46:
Chapter 2 Novel Insights into Gluco
Page 50:
1. INTRoDUCTIoN Glucocorticoid (GC)
Page 54:
which GCs enhance gene transcriptio
Page 58:
after GC-treatment has been propose
Page 62:
oral), the vulnerability of the pop
Page 66:
4.2. Glucocorticoids modulate adipo
Page 70:
metabolism by reducing the expressi
Page 74:
At older age, these mice developed
Page 78:
mice with adipose tissue-specific 1
Page 82:
REFERENCES 1. McMahon M, Gerich j,
Page 86:
31. Henriksen jE, Alford F, Vaag A,
Page 90:
60. Opherk C, Tronche F, Kellendonk
Page 94:
89. Seckl jR, Morton NM, Chapman KE
Page 98:
118. Matsumoto K, Yamasaki H, Akaza
Page 106:
PART Glucocorticoids and islet-cell
Page 112:
Chapter 3 Glucocorticoids induce be
Page 116:
Page 120:
Page 124:
Page 128:
Page 132:
Page 136:
Page 140:
Page 144:
Page 152:
Chapter 4 Glucocorticoids impair be
Page 156:
Chapter 4 Glucocorticoids impair be
Page 160: Chapter 4 Glucocorticoids impair be
Page 184: Chapter 5 Glucocorticoids, islet-ce
Page 214: REFERENCES 1. Schacke H, Docke WD,
Page 218: 29. Hamamdzic D, Duzic E, Sherlock
Page 222: Supplementary Figure 3. Patient flo
Page 230: Chapter 6 Glucocorticoid Receptor G
Page 234: Excess glucocorticoid (GC) levels i
Page 238: Figure 1. Schematic overview of the
Page 242: N363S (rs6195) AA 222 766 (722-812)
Page 246: possibility to have missed subtle e
Page 250: 14. Russcher H, Smit P, van den Akk
Page 254: SUPPLEMENTAL FILES Supplementary Fi
Page 258: Supplemental Table 2. Major inclusi
Page 262:
Haplotype 5 0 223 767 (724-813) 248
Page 268:
Chapter 7 GLP-1 prevents glucocorti
Page 272:
Page 276:
Page 280:
Page 284:
Page 288:
Page 292:
Page 298:
PART Mechanisms of glucocorticoid-i
Page 304:
Chapter 8 Glucocorticoids affect in
Page 308:
Page 312:
Page 316:
Page 320:
Page 324:
Page 328:
Page 332:
Page 336:
Page 340:
Page 344:
Page 350:
Chapter 9 Glycosphingolipid Metabol
Page 354:
INTRoDUCTIoN Glucocorticoids (GCs)
Page 358:
Experimental protocol: The design o
Page 362:
oxidative phosphorylation (OXPHOS)
Page 366:
Table 3. Mitochondrial respiration
Page 370:
prednisolone 30 mg group, and the c
Page 374:
REFERENCES 1. Schacke H, Docke WD,
Page 378:
29. Kabayama K, Sato T, Saito K, Lo
Page 386:
Chapter 10 Glucocorticoid Treatment
Page 390:
Glucocorticoids (GCs) represent the
Page 394:
capillary recruitment. Capillary re
Page 398:
elatively small numbers in each gro
Page 402:
Table 2. Metabolic parameters and b
Page 406:
Table 3. Capillary density before a
Page 410:
Prednisolone and insulin signaling
Page 414:
DISCUSSIoN This is the first study
Page 418:
glucose uptake suggesting that the
Page 422:
15. de jongh RT, Serne EH, RG Ij, d
Page 426:
SUPPLEMENTARy MATERIAL Supplemental
Page 434:
Chapter 11 Glucocorticoids alter Su
Page 438:
Glucocorticoids (GCs) are important
Page 442:
Adipose tissue was washed with ster
Page 446:
Figure 1. Effects of glucocorticoid
Page 450:
Impaired insulin action in adipose
Page 454:
REFERENCES 1. van Raalte DH, Ouwens
Page 458:
30. Ouchi N, Parker JL, Lugus JJ, W
Page 464:
Chapter 12 Angptl4 in glucocorticoi
Page 468:
Page 472:
Page 476:
Page 480:
Page 484:
Page 488:
Page 494:
PART Metabolic Effects of Glucocort
Page 500:
Chapter 13 Glucocorticoids in acute
Page 504:
Page 508:
Page 512:
Page 516:
Page 520:
Page 524:
Page 528:
Page 534:
Chapter 14 Glucose Tolerance, Insul
Page 538:
INTRoDUCTIoN Rheumatoid arthritis (
Page 542:
independent ethics committee approv
Page 546:
Glucose tolerance state: The preval
Page 550:
Data represent means ± standard de
Page 554:
**** Number of DMARDs (both synthet
Page 558:
Effect modification: As compared to
Page 562:
described here, may even be underes
Page 566:
15. Wolfe F, Michaud K. Corticoster
Page 574:
PART Discussion V
Page 580:
Chapter 15 General Discussion Gluco
Page 584:
Chapter 15 General Discussion Studi
Page 588:
Chapter 15 General Discussion Figur
Page 592:
Chapter 15 General Discussion AMP-a
Page 596:
Chapter 15 General Discussion shown
Page 600:
Chapter 15 General Discussion decre
Page 604:
Chapter 15 General Discussion Inter
Page 608:
Chapter 15 General Discussion Mecha
Page 612:
Chapter 15 General Discussion and a
Page 616:
Chapter 15 General Discussion and p
Page 620:
Chapter 15 General Discussion short
Page 624:
Chapter 15 General Discussion Table
Page 628:
Chapter 15 General Discussion REFER
Page 632:
Chapter 15 General Discussion 30. S
Page 636:
Chapter 15 General Discussion 58. L
Page 640:
Chapter 15 General Discussion 88. F
Page 644:
Chapter 15 General Discussion 119.
Page 648:
Page 652:
Page 658:
Nederlandse Samenvatting Diabetogen
Page 662:
het bleek ook heel effectief bij de
Page 666:
door prednisolon behandeling. In di
Page 670:
In deel 4 van mijn proefschrift bes
Page 678:
Dankwoord Acknowledgements
Page 682:
Geachte Dr. Ouwens, beste Margriet.
Page 686:
Dr. Kersten, beste Sander, veel dan
Page 694:
Biography
Page 698:
Daniël Henri van Raalte was born o
Page 704:
List of Publications 1. van Genugte
Page 708:
List of Publications 20. van Raalte
Page 716:
List of co-author affiliations Andr
Page 720:
List of co-author affiliations Jos
Page 724:
List of co-author affiliations Timo
Page 732:
Color Figures Chapter 1 Figure 1. O
show all

2 - TI Pharma

Create successful ePaper yourself

Delete template?

Save as template?