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Chapter 3 Glucocorticoids induce beta-cell ER stress SUPPLEMENTARy FILES Supplementary Table 1. List of Antibodies Primary antibody Supplier Reference Dilution cleaved caspase 3 R&D systems Mab835 1:1000 Insulin Santa Cruz Biotechnology sc-9168 1:1000 Insulin receptor β-subunit Santa Cruz Biotechnology sc-711 1:1000 IRE1α Cell Signaling Technology 3294 1:1000 PDX1 Santa Cruz Biotechnology sc-14664 1:1000 peIF2α-S51 Cell Signaling Technology 9721 1:1000 pPERK-T980 Santa Cruz Biotechnology 32577 1:1000 XBP1s Biolegend 619502 1:1000 XBP1t Abcam ab37151 1:1000 Supplementary Table 2. Primer sequences Gene Accession no Forward primer Reverse primer HPRT NM012583 5’-ggtccttttcaccagcaagct-3’ 5’-tgacactggcaaaacaatgca-3’ Insulin 1 NM019129 5’-gcagaagcgtggcattgtg-3’ 5’-ggtggactcsagttgcagtagttctc-3’ Insulin 2 NM019130 5’-gctggccctgctcatcct-3’ 5’-ccaccaagtgagaaccacaaag-3’ PDX1 NM022852 5’-ggtatagccagcgagatgct-3’ 5’-tcagttgggagcctgattct-3’ XBP1s NM001004210 5’-gagtccgcagcaggtg-3’ 5’-gcgtcagaatccatggga-3’ XBP1t NM001004210 5’-gagcagcaagtggtggattt-3’ 5’-tctcaatcacaagcccatga-3’ 72
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Diabetogenic Effects of Glucocortic
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VRIjE UNIVERSITEIT Diabetogenic Eff
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Leescommissie: prof.dr. M. Boers pr
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Chapter 12 Angiopoietine-like prote
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Chapter 1 General Introduction and
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Figure 1. Overview of the therapeut
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inding to the intracellular GR, fol
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further explored the effects of bot
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17. Kaplan SA, Shimizu CS. Effects
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Chapter 2 Novel Insights into Gluco
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1. INTRoDUCTIoN Glucocorticoid (GC)
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which GCs enhance gene transcriptio
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after GC-treatment has been propose
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oral), the vulnerability of the pop
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4.2. Glucocorticoids modulate adipo
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metabolism by reducing the expressi
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At older age, these mice developed
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mice with adipose tissue-specific 1
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REFERENCES 1. McMahon M, Gerich j,
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31. Henriksen jE, Alford F, Vaag A,
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60. Opherk C, Tronche F, Kellendonk
Page 94: 89. Seckl jR, Morton NM, Chapman KE
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Page 106: PART Glucocorticoids and islet-cell
Page 112: Chapter 3 Glucocorticoids induce be
Page 150: Chapter 4 Acute and 2-Week Exposure
Page 154: Glucocorticoids (GCs), such as pred
Page 158: meal beginning immediately after th
Page 162: Table 1 (Acute study). Subject char
Page 166: Figure 3. A two-week treatment with
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Page 182: Chapter 5 Islet-cell Dysfunction In
Page 186: Glucocorticoids (GCs) are the corne
Page 190: Hyperinsulinemic-euglycemic clamp a
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called the potentiation factor rati
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iAUC: β=0.126; P=0.638; R 2 =0.119
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Figure 3. Postprandial responses at
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Safety and tolerability: One subjec
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towards withdrawal of vagal activit
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REFERENCES 1. Schacke H, Docke WD,
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29. Hamamdzic D, Duzic E, Sherlock
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Supplementary Figure 3. Patient flo
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Chapter 6 Glucocorticoid Receptor G
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Excess glucocorticoid (GC) levels i
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Figure 1. Schematic overview of the
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N363S (rs6195) AA 222 766 (722-812)
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possibility to have missed subtle e
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14. Russcher H, Smit P, van den Akk
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SUPPLEMENTAL FILES Supplementary Fi
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Supplemental Table 2. Major inclusi
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Haplotype 5 0 223 767 (724-813) 248
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Chapter 7 GLP-1 prevents glucocorti
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PART Mechanisms of glucocorticoid-i
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Chapter 8 Glucocorticoids affect in
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Chapter 9 Glycosphingolipid Metabol
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INTRoDUCTIoN Glucocorticoids (GCs)
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Experimental protocol: The design o
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oxidative phosphorylation (OXPHOS)
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Table 3. Mitochondrial respiration
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prednisolone 30 mg group, and the c
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REFERENCES 1. Schacke H, Docke WD,
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29. Kabayama K, Sato T, Saito K, Lo
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Chapter 10 Glucocorticoid Treatment
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Glucocorticoids (GCs) represent the
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capillary recruitment. Capillary re
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elatively small numbers in each gro
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Table 2. Metabolic parameters and b
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Table 3. Capillary density before a
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Prednisolone and insulin signaling
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DISCUSSIoN This is the first study
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glucose uptake suggesting that the
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15. de jongh RT, Serne EH, RG Ij, d
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SUPPLEMENTARy MATERIAL Supplemental
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Chapter 11 Glucocorticoids alter Su
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Glucocorticoids (GCs) are important
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Adipose tissue was washed with ster
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Figure 1. Effects of glucocorticoid
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Impaired insulin action in adipose
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REFERENCES 1. van Raalte DH, Ouwens
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30. Ouchi N, Parker JL, Lugus JJ, W
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Chapter 12 Angptl4 in glucocorticoi
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PART Metabolic Effects of Glucocort
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Chapter 13 Glucocorticoids in acute
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Chapter 14 Glucose Tolerance, Insul
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INTRoDUCTIoN Rheumatoid arthritis (
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independent ethics committee approv
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Glucose tolerance state: The preval
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Data represent means ± standard de
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**** Number of DMARDs (both synthet
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Effect modification: As compared to
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described here, may even be underes
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15. Wolfe F, Michaud K. Corticoster
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PART Discussion V
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Chapter 15 General Discussion Gluco
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Chapter 15 General Discussion Studi
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Chapter 15 General Discussion Figur
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Chapter 15 General Discussion AMP-a
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Chapter 15 General Discussion shown
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Chapter 15 General Discussion decre
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Chapter 15 General Discussion Inter
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Chapter 15 General Discussion Mecha
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Chapter 15 General Discussion and a
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Chapter 15 General Discussion and p
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Chapter 15 General Discussion short
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Chapter 15 General Discussion Table
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Chapter 15 General Discussion REFER
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Chapter 15 General Discussion 30. S
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Chapter 15 General Discussion 58. L
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Chapter 15 General Discussion 88. F
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Chapter 15 General Discussion 119.
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Nederlandse Samenvatting Diabetogen
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het bleek ook heel effectief bij de
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door prednisolon behandeling. In di
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In deel 4 van mijn proefschrift bes
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Dankwoord Acknowledgements
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Geachte Dr. Ouwens, beste Margriet.
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Dr. Kersten, beste Sander, veel dan
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Biography
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Daniël Henri van Raalte was born o
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List of Publications 1. van Genugte
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List of Publications 20. van Raalte
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List of co-author affiliations Andr
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List of co-author affiliations Jos
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List of co-author affiliations Timo
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Color Figures Chapter 1 Figure 1. O
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