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29. Shimizu N, Yoshikawa N, Ito N, Maruyama T, Suzuki Y, Takeda S, Nakae j, Tagata Y, Nishitani S, Takehana K, Sano M, Fukuda K, Suematsu M, Morimoto C, Tanaka H. Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle. Cell Metab. 2011;13(2):170-82. 30. Xu j, Winkler j, Derendorf H. A pharmacokinetic/pharmacodynamic approach to predict total prednisolone concentrations in human plasma. j <strong>Pharma</strong>cokinet <strong>Pharma</strong>codyn. 2007;34(3):355-72. 31. van Raalte DH, van Genugten RE, Linssen MM, Ouwens DM, Diamant M. Glucagon-Like Peptide-1 Receptor Agonist Treatment Prevents Glucocorticoid-Induced Glucose Intolerance and Islet-Cell Dysfunction in Humans. Diabetes Care. 2011. 32. Cunha DA, Ladriere L, Ortis F, Igoillo-Esteve M, Gurzov EN, Lupi R, Marchetti P, Eizirik DL, Cnop M. Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and junB. Diabetes. 2009;58(12):2851-62. 33. Yusta B, Baggio LL, Estall jL, Koehler jA, Holland DP, Li H, Pipeleers D, Ling Z, Drucker Dj. GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress. Cell Metab. 2006;4(5):391-406. 71 3 Chapter 3
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Diabetogenic Effects of Glucocortic
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VRIjE UNIVERSITEIT Diabetogenic Eff
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Leescommissie: prof.dr. M. Boers pr
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Chapter 12 Angiopoietine-like prote
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Chapter 1 General Introduction and
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Figure 1. Overview of the therapeut
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inding to the intracellular GR, fol
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further explored the effects of bot
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17. Kaplan SA, Shimizu CS. Effects
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Chapter 2 Novel Insights into Gluco
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1. INTRoDUCTIoN Glucocorticoid (GC)
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which GCs enhance gene transcriptio
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after GC-treatment has been propose
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oral), the vulnerability of the pop
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4.2. Glucocorticoids modulate adipo
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metabolism by reducing the expressi
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At older age, these mice developed
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mice with adipose tissue-specific 1
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REFERENCES 1. McMahon M, Gerich j,
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31. Henriksen jE, Alford F, Vaag A,
Page 90: 60. Opherk C, Tronche F, Kellendonk
Page 94: 89. Seckl jR, Morton NM, Chapman KE
Page 98: 118. Matsumoto K, Yamasaki H, Akaza
Page 106: PART Glucocorticoids and islet-cell
Page 112: Chapter 3 Glucocorticoids induce be
Page 150: Chapter 4 Acute and 2-Week Exposure
Page 154: Glucocorticoids (GCs), such as pred
Page 158: meal beginning immediately after th
Page 162: Table 1 (Acute study). Subject char
Page 166: Figure 3. A two-week treatment with
Page 170: prednisolone, as the most widely pr
Page 174: REFERENCES 1. Schacke H, Docke WD,
Page 182: Chapter 5 Islet-cell Dysfunction In
Page 186: Glucocorticoids (GCs) are the corne
Page 190: Hyperinsulinemic-euglycemic clamp a
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called the potentiation factor rati
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iAUC: β=0.126; P=0.638; R 2 =0.119
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Figure 3. Postprandial responses at
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Safety and tolerability: One subjec
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towards withdrawal of vagal activit
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REFERENCES 1. Schacke H, Docke WD,
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29. Hamamdzic D, Duzic E, Sherlock
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Supplementary Figure 3. Patient flo
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Chapter 6 Glucocorticoid Receptor G
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Excess glucocorticoid (GC) levels i
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Figure 1. Schematic overview of the
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N363S (rs6195) AA 222 766 (722-812)
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possibility to have missed subtle e
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14. Russcher H, Smit P, van den Akk
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SUPPLEMENTAL FILES Supplementary Fi
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Supplemental Table 2. Major inclusi
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Haplotype 5 0 223 767 (724-813) 248
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Chapter 7 GLP-1 prevents glucocorti
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PART Mechanisms of glucocorticoid-i
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Chapter 8 Glucocorticoids affect in
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Chapter 9 Glycosphingolipid Metabol
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INTRoDUCTIoN Glucocorticoids (GCs)
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Experimental protocol: The design o
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oxidative phosphorylation (OXPHOS)
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Table 3. Mitochondrial respiration
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prednisolone 30 mg group, and the c
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REFERENCES 1. Schacke H, Docke WD,
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29. Kabayama K, Sato T, Saito K, Lo
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Chapter 10 Glucocorticoid Treatment
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Glucocorticoids (GCs) represent the
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capillary recruitment. Capillary re
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elatively small numbers in each gro
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Table 2. Metabolic parameters and b
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Table 3. Capillary density before a
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Prednisolone and insulin signaling
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DISCUSSIoN This is the first study
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glucose uptake suggesting that the
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15. de jongh RT, Serne EH, RG Ij, d
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SUPPLEMENTARy MATERIAL Supplemental
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Chapter 11 Glucocorticoids alter Su
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Glucocorticoids (GCs) are important
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Adipose tissue was washed with ster
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Figure 1. Effects of glucocorticoid
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Impaired insulin action in adipose
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REFERENCES 1. van Raalte DH, Ouwens
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30. Ouchi N, Parker JL, Lugus JJ, W
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Chapter 12 Angptl4 in glucocorticoi
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PART Metabolic Effects of Glucocort
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Chapter 13 Glucocorticoids in acute
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Chapter 14 Glucose Tolerance, Insul
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INTRoDUCTIoN Rheumatoid arthritis (
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independent ethics committee approv
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Glucose tolerance state: The preval
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Data represent means ± standard de
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**** Number of DMARDs (both synthet
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Effect modification: As compared to
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described here, may even be underes
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15. Wolfe F, Michaud K. Corticoster
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PART Discussion V
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Chapter 15 General Discussion Gluco
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Chapter 15 General Discussion Studi
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Chapter 15 General Discussion Figur
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Chapter 15 General Discussion AMP-a
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Chapter 15 General Discussion shown
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Chapter 15 General Discussion decre
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Chapter 15 General Discussion Inter
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Chapter 15 General Discussion Mecha
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Chapter 15 General Discussion and a
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Chapter 15 General Discussion and p
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Chapter 15 General Discussion short
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Chapter 15 General Discussion Table
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Chapter 15 General Discussion REFER
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Chapter 15 General Discussion 30. S
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Chapter 15 General Discussion 58. L
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Chapter 15 General Discussion 88. F
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Chapter 15 General Discussion 119.
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Nederlandse Samenvatting Diabetogen
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het bleek ook heel effectief bij de
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door prednisolon behandeling. In di
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In deel 4 van mijn proefschrift bes
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Dankwoord Acknowledgements
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Geachte Dr. Ouwens, beste Margriet.
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Dr. Kersten, beste Sander, veel dan
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Biography
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Daniël Henri van Raalte was born o
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List of Publications 1. van Genugte
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List of Publications 20. van Raalte
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List of co-author affiliations Andr
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List of co-author affiliations Jos
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List of co-author affiliations Timo
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Color Figures Chapter 1 Figure 1. O
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