2 - TI Pharma

CoNTENT
Part I Introduction
Chapter 1 General introduction and outline of the thesis 11
Chapter 2 Novel insights into glucocorticoid-mediated diabetogenic 23
effects: towards expansion of therapeutic options?
Part II Glucocorticoids and islet-cell fuction
Chapter 3 Prednisolone-induced beta-cell dysfunction is associated with 55
impaired endoplasmic reticulum homeostasis in INS-1E cells.
Chapter 4 Acute and 2-week exposure to prednisolone impair different 75
aspects of beta-cell function in healthy men.
Chapter 5 Islet-cell dysfunction induced by glucocorticoid treatment: 91
role for altered sympathovagal balance?
Chapter 6 Glucocorticoid receptor gene polymorphisms are associated 115
with reduced first-phase glucose-stimulated insulin secretion
and disposition index in women, but not in men.
Chapter 7 GLP-1 receptor agonist treatment prevents glucocorticoid 133
induced glucose intolerance and islet-cell dysfunction in
humans.
Part III Mechanisms of glucocorticoid-induced insulin resistance
Chapter 8 Low-dose glucocorticoid treatment affects multiple aspects
of intermediary metabolism in healthy humans: a randomized
controlled trial.
151
Chapter 9 Glycosphingolipid metabolism and mitochondrial function do
not explain glucocorticoid-induced insulin resistance in
healthy men
175
Chapter 10 Glucocorticoid treatment impairs microvascular function in
healthy males, in association with its adverse effects on
glucose metabolism and blood pressure.
193
Chapter 11 Glucocorticoids alter subcutaneous adipose tissue function
and adipokine secretion in vivo in healthy men
217