EURON and THEME joint PhD meeting

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66 EURON and THEME joint meeting 2011 Abnormal functional connectivity between areas involved in emotion and executive control in psychogenic non-epileptic seizures (PNES) S.J.M. van der Kruijs 1,2 , N.M.G. Bodde 1 , M.J. Vaessen 1,2 , R.H. Lazeron 1 , P.A. Hofman 1,2 , W.H. Backes 2 , A.P. Aldenkamp 1,2 , J.F.A. Jansen 2 1 Epilepsy Center Kempenhaeghe, Heeze, Netherlands; 2 Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands. Introduction Psychogenic non-epileptic seizures (PNES) are paroxysmal episodes without epileptiform brain activity as recorded by EEG. Instead, there is positive evidence for psychogenic factors that may underlie the seizures. One important predisposition factor for PNES is dissociation, i.e. disrupted integration of conscious functioning. We explored whether fMRI could identify biomarkers of brain alterations associated with dissociation in PNES. Methods Patients with PNES (n=11) and healthy volunteers (n=12) completed dissociation questionnaires (DIS-Q, DES and SDQ-20), and the Raven’s Progressive Matrices Test. The fMRI protocol consisted of 4 scans: Resting state fMRI (rsfMRI) 1, picture encoding, Stroop color naming, and rsfMRI 2. All MR images were preprocessed in SPM8, and between-group differences in cerebral activation were assessed. Subsequently, ROIs with strong activation were defined, based on the activation patterns during the tasks, averaged over all subjects. Based on the ROIs, functional connectivity maps were obtained from resting-state fMRI. Multiple regression was performed to assess between-group differences (p
67 EURON and THEME joint meeting 2011 Conclusion The abnormal strong functional connectivity in PNES patients provides a neurophysiological correlate for an underlying dissociation mechanism where emotion can result in altered motor control, resulting in seizure-like episodes.
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Information about THEME 3 EURON and
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EURON a short introduction 7 EURON
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Programme 13 EURON and THEME joint
Page 17 and 18: Thursday September 22 nd 9:00 - 10:
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Page 25 and 26: EURON Lecture Frank Kirchhoff ADDRE
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Page 29 and 30: THEME Lecture Eckhard Mandelkow POS
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Page 35 and 36: 33 Euron PhD meeting 2010 Methodolo
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Page 105 and 106: List of Participants 103 EURON and
Page 107 and 108: Nuersailike Abuduwali University of
Page 109 and 110: Marianne Eisenhardt University of B
Page 111 and 112: Sabine Klein University of Bonn PhD
Page 113 and 114: Viktoriya Peeva University of Bonn
Page 115: Sylvie van der Kruijs Maastricht Un
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EURON and THEME joint PhD meeting

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