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The primary emulsion was still
viscous. However when the SLS
concentration increases (10 CMC), it
was possible to obtain a double
emulsion structure with biglicined iron
in the acuose internal phase. The
inner drop diameter was 0.25-0.47
mm and the outer drop diameter was
15-30 mm.
Figure 4 presents the double
emulsions prepared with 32% of
SPAN 80. The dispersion of the
primary emulsion is better, but there
were some clusters. The high
concentration of emulsifying agent
span 80, was too much and increases
the viscosity, stopping the
desegregation of the primary
emulsion.
CONCLUSSION
According to this study, it is possible
to prepare double emulsions W/O/W
containing 90% of biglicined iron
solution in the primary emulsion by
using a span 80 concentration of 17%
as oleic emulsifying agent, SLS at 10
CMC (8E-2M) and 5% of hydropropil
cellulose.
BIBLIOGRAPHY
1. Alexey Kabalnov (1996)
Macroemulsion Stability: The Oriented
Wedge Theory Revisited. Langmuir
1996, 12, 276-292.
2. Dhanorkar et al., (2001) Formation
and Stability Studies of multiple (w/o/w)
Emulsions Prepared with Newly
Synthesized Rosin-Based Polymeric
Surfactants. Drug Development and
Industrial Pharmacy, 27(6), 591–598.
a)
b)
c)
Fig. 4. Doubles Emulsions obtained with 32%
Span80 and: a) 0.1CMC de SLS; b) CMC de
SLS; c) 10CMC de SLS as emulsifying
agents