Scientific Program Committee

Poster Litings
Session 65 CROI 2008
375b Disturbed Gut Microbiota in HAART-naïve HIV +
Adults: Effect of Intervention with a Specific Prebiotic
Oligosaccharide Mixture
Kaouther Ben Amor* 1 , G Rizzardini2 , C Torti3 , T Quirino4 , M Moroni2 ,
J Knol1 , D Bray5 , A Vriesema1 , M Clerici6 , and A Gori7 1 2 Numico Res, Wageningen, The Netherlands; Hosp Luigi Sacco, Milan,
Italy; 3Univ of Brescia, Italy; 4Hosp Busto Arsizio, Italy; 5ImmunoClin, Paris, France; 6Univ of Milan, Italy; and 7Hosp San Gerardo, Univ of
Milan-Bicocca, Monza, Italy
376 Functional Analysis of Intestinal Epithelial Cells Isolated by
Laser Dissection from SIV-infected Rhesus Macaques in vivo
Michael George*, S Sankaran, I Grishina, and S Dandekar
Univ of California, Davis, US
377 Microbial Translocation Is a Determinant of Persisting
T Cell Hyperactivation in HIV-infected Patients Failing to
Recover CD4 following Long-term HAART
Giusi Maria Bellistri* 1 , V Pegorer1 , C Tincati1 , L Meroni2 , A Gori3 ,
A d’Arminio Monforte1 , and G Marchetti1 1 2 San Paolo Hosp, Univ of Milan, Italy; Luigi Sacco Hosp, Univ of Milan,
Italy; and 3San Gerardo Hosp, Monza, Italy
b Wednesday, 1-4 pm; Hall D
Session 66–Poster Abstracts
Monocyte/Macrophage Studies
378 Up-regulation of PD-L1 on Monocytes and Dendritic Cells by
HIV-1-derived ssRNA
Angela Meier* 1 , A Bagchi2 , H Sidhu1 , G Alter1 , T Suscovich1 ,
H Streeck1 , M Brockman1 , S LeGall1 , J Hellman2 , and M Altfeld1 1Partners AIDS Res Ctr, Massachusetts Gen Hosp, Harvard Med Sch,
Charlestown, US and 2Massachusetts Gen Hosp, Harvard Med Sch,
Boston, US
379 Monocyte Heterogeneity Underlying Phenotypic Changes in
Monocytes according to SIV Disease Stage
Woong-Ki Kim* 1 and K Williams2 1 2 Eastern Virginia Med Sch, Norfolk, US and Boston Coll, Chestnut Hill,
MA, US
380 HIV-mediated Dysregulation of Zinc Homeostasis Confers
Resistance to Apoptosis in Circulating Monocytes during
Viremia
A Raymond1 , B Gekonge1 , A Hancock1 , J Chehimi1 , E Papasavvas1 ,
K Mounzer2 , and Luis Montaner* 1
1 2 Wistar Inst, Philadelphia, PA, US and Philadelphia Field Initiating
Group for HIV Trials, PA, US
381 HIV Modulates Host Gene Expression in Macrophages after
IFN-α2 Treatment
Melissa Sirois* 1 , L Robitaille1 , M Shah1 , C Woelk2 , and J Corbeil1 1 2 Infectious Disease Res Ctr, Laval Univ, Canada and Univ of California,
San Diego, US
382 HIV-1 Activates Macrophages Independent of Toll-like
Receptors, a Potential Mechanism for Dysregulation of
Innate Immunity
Joseph Brown* 1 , J Kohler2 , C Coberley1 , J Sleasman3 , and M Goodenow1 1 2 Univ of Florida Coll of Med, Gainesville, US; Emory Univ, Atlanta, GA,
US; and 3Univ of South Florida Coll of Med and All Children’s Hosp, St
Petersburg, US
383 HIV-1 ssRNA Triggers a Vitamin D-dependent Antiviral
Pathway in Human Monocytes
P Hong, K Corcoran, R Modlin, B Lee, and Stephan Krutzik*
Univ of California, Los Angeles, US
b Monday, 1-4 pm; Hall D
Session 67–Poster Abstracts
Therapy and CNS Infection
384 Predictors of Clinical Outcome and Viro-immunological
Response to cART in an Italian Cohort of HIV-infected Naïve
Patients Affected by Neurological Disorders
M Giancola1 , P Lorenzini1 , A Cingolani2 , M Bongiovanni3 , S Bossolasco4 ,
B Vigo5 , M Finazzi6 , S Casari7 , P Cinque4 , Andrea Antinori* 1 , and Italian
Registry Investigative Neuro AIDS (IRINA) Study Group
1Natl Inst for Infectious Diseases “Lazzaro Spallanzani”, IRCCS, Rome,
Italy; 2Univ Cattolica del Sacro Cuore, Rome, Italy; 3Univ of Milan, Italy;
4 5 6 San Raffaele Sci Inst, Milan, Italy; Niguarda Hosp, Milan, Italy; Hosp
Riuniti, Bergamo, Italy; and 7Univ degli Studi, Brescia, Italy
385 Intracerebral Penetrating ART Are More Efficient on
Survival of HIV + Patients with Progressive Multifocal
Leukoencephalopathy (ANRS CO4 - FHDH)
Jacques Gasnault* 1 , E Lanoy2,3 , M Bentata4 , M Guiguet2,3 , and
D Costagliola2,3 1 2 Hosp Bicetre, Le Kremlin Bicetre, France; INSERM U720, Paris,
France; 3Univ Pierre and Marie Curie, Paris, France; and 4Hosp Avicenne, Bobigny, France
32 15th Conference on Retroviruses and Opportunistic Infections
386 Effect of Combined ART on Brain and Lymphoid Tissue
Virus Burden in An Accelerated Model of SIV Encephalitis in
Rhesus Macaques
Lakshmanan Annamalai* 1 , S Westmoreland1 , D Pauley1 , K Williams2 ,
E Ratai3 , M Lentz3 , R Schinazi4 , N Bischofberger5 , G Gonzalez3 , and
S O’Neil1 1New England Primate Res Ctr, Harvard Med Sch, Southborough, MA,
US; 2Boston Univ, MA, US; 3AA Martinos Ctr for Biomed Imaging,
Massachusetts Gen Hosp, Charlestown, US; 4Emory Univ Sch of Med and
VAMC, Atlanta, GA, US; and 5Gilead Sci, Foster City, CA, US
387 Intermediate (12 Months) and Long-term (6 Years) Cognitive
Response to HAART in 2 Thai Cohorts
V Valcour1,2,3 , P Sithinamsuwan4 , W Pumpradit5 , J Ananworanich1,3 ,
S Nidhinandana4 , W Apateerapong3 , K Robertson6 , R Paul7 , U Siangphoe3 ,
Cecilia Shikuma* 1,3 , and Southeast Asia Res Collaboration with Hawaii
(SEARCH) 001 Protocol Team
1 2 Hawaii AIDS Clinical Res Prgm, Univ of Hawaii, Honolulu, US; Univ of
California, San Francisco, US; 3South East Asia Res Collaboration with
Univ of Hawaii, Bangkok, Thailand; 4Phramongkutklao Hosp, Bangkok,
Thailand; 5HIV Netherlands Australia Thailand Res Collaboration,
Bangkok; 6Univ of North Carolina at Chapel Hill, US; and 7Univ of
Missouri, St Louis, US
388 Baseline Data from ACTG 5199: The International
Neurological Study
Kevin Robertson* 1 , J Kumwenda2 , K Supparatpinyo3 , S Evans4 , J Jiang4 ,
T Campbell5 , R Price6 , and ACTG 5199 Study Team
1 2 Univ of North Carolina at Chapel Hill, US; Queen Elizabeths, Blantyre,
Malawi; 3Chiang Mai Univ, Thailand; 4Harvard Univ, Boston, MA, US;
5 6 Univ of Colorado Hlth Sci Ctr, Denver, US; and Univ of California, San
Francisco, US
389 Adverse Effect of ddI, ddC, and d4T as a Component of
HAART on Cognitive Function during HIV Infection
Ingo Husstedt*, B Hudelmeier, U Oelker-Gruneberg, N Gregor,
K Kloenne, K Biehl, O Summ, and S Evers
Univ Hosp Muenster, Germany
390 CEP-1347 as an Adjunctive Therapy for HIV-associated
Cognitive Impairment
Dawn Eggert* 1 , S Gorantla1 , H Dou1 , L Poluektova1 ,
D Bozyczko-Coyne2 , L Aimone2 , S Dewhurst3 , S Maggirwar3 ,
H Gelbard3 , and H Gendelman1 1 2 Univ of Nebraska Med Ctr, Omaha, US; Cephalon, Inc, West Chester,
PA, US; and 3Univ of Rochester Med Ctr, NY, US
b Monday, 1-4 pm; Hall D
Session 68–Poster Abstracts
(see Session 26 on Tuesday for corresponding Poster Discussion)
Clinical Developments in Neuropathogenesis
391 Changes in Cognition during HAART: Comparison of 2
Different Scoring Systems to Measure Antiretroviral Drug
Efficacy on HIV Dementia
Valerio Tozzi*, P Balestra, M Salvatori, C Vlassi, G Liuzzi,
S Menichetti, M Zaccarelli, S Cerilli, A Antinori, and P Narciso
Natl Inst for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy
392 CSF Neural Marker Profile Distinguishes AIDS Dementia
Complex from Alzheimer’s Disease
Magnus Gisslen* 1 , K Blennow1 , B Brew2 , P Cinque3 , L Hagberg1 ,
R Price4 , and H Zetterberg1 1 2 Sahlgrenska Univ Hosp, Gothenburg, Sweden; St Vincent’s Hosp, Univ
of New South Wales, Sydney, Australia; 3San Raffaele Hosp, Milan, Italy;
and 4Univ of California, San Francisco, US
393 HIV Protease Inhibitors and Risk of Peripheral Neuropathy
Ronald Ellis* 1 , J Marquie-Beck1 , P Delaney1 , T Alexander1 , D Clifford2 ,
J McArthur3 , D Simpson4 , C Ake1 , A Collier5 , B Gelman6 , and the
CHARTER Group
1 2 Univ of California, San Diego, US; Washington Univ, St Louis, MO, US;
3 4 Johns Hopkins Univ, Baltimore, MD, US; Mt Sinai Sch of Med, New
York, NY, US; 5Univ of Washington, Seattle, US; and 6Univ of Texas Med
Branch, Galveston, US
394 ART Resistance Influences CSF HIV RNA Levels and
Neuropsychological Performance in HIV-infected Individuals
George Hightower* 1 , S Letendre1 , M Cherner1 , S Gibson1 , R Ellis1,2 ,
C Ignacio1 , R Heaton1 , I Grant1,2 , D Richman1,2 , D Smith1,2 , and San Diego
HIV Neurobehavioral Res Ctr (HNRC) Group
1 2 Univ of California, San Diego, US and San Diego VA Hlthcare Systems,
CA, US
395 CSF t-τ, p-τ and Amyloid-β 1-42 in HIV Infection
Bruce Brew* 1 , M Gisslen2 , L Pemberton1 , P Cinque3 , L Hagberg2 ,
R Price4 , K Blennow2 , H Zetterberg2 , and S Spudich4 1 2 3 St Vincent’s Hosp, Sydney Australia; Gothenburg Univ, Sweden; San
Raffaele Hosp, Milan, Italy; and 4Univ of California, San Francisco, US
396a Comparative Analysis of HIV-specific CD8 + T Cells in
Cerebrospinal Fluid and Peripheral Blood among Treatmentnaïve
HIV-immune Controllers
Shanmugalakshmi Sadagopal*, S Lorey, L Barnett, R Basham,
L Lebo, H Erdem, K Haman, M Avison, D Haas, and S Kalams
Vanderbilt Univ, Nashville, TN, US