Scientific Program Committee

CROI 2008 Session 60
307a HIV-specific B Cells Are Enriched in a Dysfunctional Memory
B Cell Compartment in HIV-infected Viremic Individuals
Susan Moir*, J Ho, A Malaspina, W Wang, A DiPoto, M O’Shea,
G Roby, J Arthos, TW Chun, and A Fauci
NIAID, NIH, Bethesda, MD, US
307b KIR/HLA Genotypes that Inhibit NK Cell Activation Are
Associated with Protection against HIV-1 Disease Progression
Wim Jennes* 1 , S Verheyden2 , C Demanet2 , O Tossou3 , B Vuylsteke1 , and
L Kestens1 1 2 Inst of Tropical Med, Antwerp, Belgium; Univ Hosp Brussels, Belgium;
and 3Project RETRO-CI, Abidjan, Côte d`Ivoire
307c Severe Primary Sexually Transmitted HIV Infection Due to
Dual-tropic HIV-1
J Dalmau1 , M Puertas1 , M Azuara2 , A Marino3 , N Izquierdo-Useros1 ,
M Buzon1 , R Paredes1 , C Rodrigo2 , Bonaventura Clotet* 1,2 , and
J Martinez-Picado1,4 1 2 Fndn irsiCaixa, Badalona, Spain; Hosp Univ Germans Trias i Pujol,
Badalona, Spain; 3Hosp Arquitecto Marcide, El Ferrol, Spain; and
4ICREA, Barcelona, Spain
b Monday, 1-4 pm; Hall D
Session 58–Poster Abstracts
Factors Impacting Viral Replication in vivo
308 Increased Levels of APOBEC3G mRNA in Highly Exposed
Persistently Seronegative Individuals and Individuals with
Long Term Low Viral Loads
Joel Vazquez-Perez*, R Hernandez, C Ormsby, and G Reyes-Teran
Natl Inst of Respiratory Diseases, Mexico City, Mexico
309 Levels of APOBEC3G and APOBEC3F mRNA Increase Post
HIV-1 Infection Associated with Low Viral Set-point
Nzovu Ulenga* 1 , A Dieng Sarr1 , S Thakore-Meloni1 , JL Sankale1 ,
G Eisen1 , A Gueye-NDiaye2 , S MBoup2 , and P Kanki1 1 2 Harvard Sch of Publ Hlth, Boston, MA, US and Cheikh Anta Diop Univ,
Dakar, Senegal
310 Viral Replication is Sustained by Short-lived Infected Cells in
SIVagm-infected African Green Monkeys
Ivona Pandrea* 1 , R Ribeiro2 , R Gautam1 , T Gaufin1 , C Monjure1 ,
M Pattison1 , G Silvestri3 , M Miller4 , A Perelson2 , and C Apetrei1 1 2 Tulane Natl Primate Res Ctr, Covington, LA, US; Los Alamos Natl
Lab, NM, US; 3Univ of Pennsylvania, Philadelphia, US; and 4Gilead Sci,
Foster City, CA, US
311 Evolution in HIV-1 gag and env Is Differentially Associated
with Viral Load and the Immune Response at Different
Times in Infection
Anne Piantadosi* 1,2 , B Chohan1,2 , D Panteleeff1 , Z Jalalian-Lechak1 ,
J Baeten2 , and J Overbaugh1 1 2 Fred Hutchinson Cancer Res Ctr, Seattle, WA, US and Univ of
Washington, Seattle, US
312 Genome-wide HLA-associated Selection in HIV-1 and
Protein-specific Correlations with Viral Load: An ACTG
5142 Study
M John1 , D Heckerman2 , L Park1 , S Gaudieri1 , A Chopra1 , J Carlson2 ,
I James1 , D Nolan1 , R Haubrich3 , Simon Mallal* 1 , and ACTG 5142 Study
Team
1Ctr for Clinical Immunology and Biomed Statistics, Murdoch Univ, Royal
Perth Hosp, Australia; 2Microsoft Res, Redmond WA, US; and 3Antiviral Res Ctr, San Diego, CA, US
313 Contribution of NK Cells to the Control of Primary SIV
Infection in Rhesus Monkeys
Elisa Choi*, N Letvin, K Reimann, and Ctr for HIV/AIDS Vaccine
Immunology (CHAVI)
Beth Israel Deaconess Med Ctr, Boston, MA, US
314 Higher Frequencies of γ δ T Cells Are Associated with
Undetectable Plasma Viral Loads in HIV-2 Infections
N Zheng1,2 , J McElrath1,2 , S Sow3 , A Mesher1 , S Hawes1 , J Stern1 ,
Geoffrey Gottlieb* 1 , S De Rosa1,2 , and N Kiviat1 1 2 Univ of Washington, Seattle, US; Fred Hutchinson Cancer Res Ctr,
Seattle, WA, US; and 3Univ of Dakar, Senegal
315 HIV-1-induced Activation of CD4 + T Cells Creates New Targets
for HIV-1 Infection in Human Lymphoid Tissue ex vivo
Angelique Biancotto* 1 , JC Grivel1 , I Hirsch2 , C Vanpouille1 , A Lisco1 ,
and L Margolis1 1Natl Inst of Child Hlth and Human Devt, NIH, Bethesda, MD, US and
2INSERM UMR 599, Marseille, France
316 Alloantigen Exposure Alters the Susceptibility to Cellassociated
Mucosal FIV Challenge
Surender Kumar*, S Leavell, B Assogba, and M Burkhard
Ohio State Univ, Columbus, US
317 WFDC1/ps20 Is a Novel Innate Immunomodulatory Signature
Protein of HIV permissive CD4 + CD45RO + Memory T Cells
that Promotes Infection by Up-regulating CD54 Integrin
Expression and Is Elevated in HIV-1 Infection
Raymond Alvarez*, J Reading, P Easterbrook, and A Vyakarnam
King’s Coll London, UK
318 Foreskin Langerhans’ Cell Density of HIV Infected and
Uninfected Men in Rakai, Uganda
Kristine Johnson* 1 , J Taube 1 , R Sharma 1 , A Rabkin 2 , D Serwadda 3 ,
G Kigozi 3 , S Watya 3 , M Wawer 3,4 , R Gray 3,4 , and T Quinn 1,5
1 Johns Hopkins Univ Sch of Med, Baltimore, MD, US; 2 Stanford Univ,
Palo Alto, CA, US; 3 Rakai Hlth Sci Prgm, Kalisizo, Uganda; 4 Johns
Hopkins Univ Bloomberg Sch of Publ Hlth, Baltimore, MD, US; and
5 NIAID, NIH, Bethesda, MD, US
b Monday, 1-4 pm; Hall D
Session 59–Poster Abstracts
Studies on Viral Evolution in vivo
319 Nonlinear Accumulation of Genetic Diversity in HIV-1
Infection
Mary Kearney* 1 , F Maldarelli 1 , W Shao 1 , E Daar 2 , J Margolick 3 ,
V Boltz 1 , J Mellors 4 , J Coffin 5 , and S Palmer 1
1 NCI-Frederick, MD, US; 2 Univ of California, Los Angeles AIDS Inst, US;
3 Johns Hopkins Univ Bloomberg Sch of Publ Hlth, Baltimore, MD, US;
4 Univ of Pittsburgh, PA, US; and 5 Tufts Univ, Boston, MA, US
320 Sequence Conservation and Viral Fitness in Circulating
HIV-1 Sequences
Morgane Rolland* 1 , L Heath 1 , W Deng 1 , D Heckerman 2 , and J Mullins 1
1 Univ of Washington Sch of Med, Seattle, US and 2 Machine Learning and
Applied Statistics Group, Microsoft Res, Redmond, WA, US
321 Increasing Mutations in HIV-1 DNA from Sputum vs
Peripheral Blood during Effective ART
Thor Wagner* 1,2 , N Tobin 3 , J McKernnan 2 , K Mohan 2 , A Melvin 1,2 ,
M Xu 1,2 , G Learn 1 , J Mullins 1 , and L Frenkel 1,2
1 Univ of Washington, Seattle, US; 2 Children’s Hosp and Regional Med Ctr,
Seattle, WA, US; and 3 Santa Clara Valley Med Ctr, San Jose, CA, US
322 High Viral Load and Weak Humoral Immunity, but Not
Target Cell Availability, Are Factors Driving X4 Virus
Evolution and Emergence in Rhesus Macaques
Amy Li*, SH Ho, V Sahi, and C Cheng-Mayer
Aaron Diamond AIDS Res Ctr, The Rockefeller Univ, New York, NY, US
323 Envelope Modifications over the Course of Infection Confer a
Greater Ability to Utilize the CCR5 Receptor
A Fellows1 , A Kamat1 , B Kwambana1 , J Overbaugh2 , and Manish Sagar* 1
1 2 Brigham and Women’s Hosp, Cambridge, MA, US and Fred Hutchinson
Cancer Res Ctr, Seattle, WA, US
b Tuesday, 1-4 pm; Hall D
Session 60–Poster Abstracts
CTL Studies and Consequences of Immune Escape
324 Transmission of HIV-1 CTL Escape Variants Provides HLAmismatched
Recipients with a Survival Advantage
Denis Chopera* 1 , Z Woodman1 , M Mlotshwa2 , D Martin1 , C Seoighe1 ,
D Assis de Rosa2 , K Mlisana3 , S Abdool Karim3 , C Gray2 , and
C Williamson1 1 2 Univ of Cape Town, South Africa; Natl Inst for Communicable Diseases,
Johannesburg, South Africa; and 3Univ of KwaZulu Natal, Durban, South
Africa
325 Long-term Stability of Compensated CD8 Escape Mutations
following HIV Transmission to HLA-Mismatched Individuals
Arne Schneidewind*, B Li, A Gladden, R Allgaier, E Rosenberg,
B Walker, and T Allen
Partners AIDS Res Ctr, Massachusetts Gen Hosp, Harvard Med Sch,
Boston, US
326 HIV-1 CTL Escape Mutation Contribute to Dendritic
Cell Dysfunction by Increasing pMHC Class I Binding to
Inhibitory Myelomonocytic Receptors
Huang Jinghe*, M Lichterfeld, D Kavanagh, K Williams, T Miura,
F Pereyra, A Trocha, R Gandhi, B Walker, and X Yu
Partners AIDS Res Ctr, Massachusetts Gen Hosp, Harvard Univ Ctr for
AIDS Res, Boston, US
327 Dense Networks of Correlated Substitutions Accompany
Adaptations to HLA-restricted CTL Epitopes
Jonathan Carlson* 1,2 , Z Brumme3 , C Brumme3 , L Swenson4 , S Szeto4 ,
I Tao4 , C Kadie1 , B Walker3,5 , R Harrigan4 , and D Heckerman1 1 2 Microsoft Res, Redmond, WA, US; Univ of Washington, Seattle, US;
3 4 Partners AIDS Res Ctr, Boston, MA, US; BC Ctr for Excellence in HIV/
AIDS, Vancouver, Canada; and 5Howard Hughes Med Inst, Chevy Chase,
MD, US
328 CTL Escape Mutations within the HIV-1 Nef HLA-
B8-restricted CTL Epitope FL8 Correlate with Disease
Progression in HLA-B8 Patients
Katja Maurer*, E Harrer, A Goldwich, K Eismann, S Bergmann,
M Schmitt-Haendle, B Spriewald, S Mueller, and T Harrer
Univ Erlangen-Nuremberg, Germany
Program 29
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