Scientific Program Committee

Poster Litings
Session 55
280a Latent/Persistent HIV-1 Infection Is Most Likely to Develop
in Minimally Activated Bystander CD4 T Cells
Paula Soto*, V Terry, and C Spina
Univ of California, San Diego and VA San Diego Hlthcare System, US
280b HIV-1 Replicates Locally in Sub-compartments of Female
Genital Tract
MariaPia De Pasquale* 1 , L Sutton2 , J Ingersoll3 , A Caliendo3 ,
J Kurpewski1 , S Chapman1 , S Cu-Uvin1 , and R D’Aquila2 1 2 Brown Univ, Providence, RI, US; Vanderbilt Univ, Nashville, TN, US;
and 3Emory Univ, Atlanta, GA, US
b Wednesday, 1-4 pm; Hall D
Session 56–Poster Abstracts
Viral Transmission: Molecular Studies
281 Visualization of HIV Interaction with Adult Human Foreskin
Explants
Minh Dinh* 1 , S McCoombe2 , M McRaven2 , N Byers2 , and T Hope2 1Feinberg Sch of Med, Northwestern Univ, Chicago, IL, US and
2Northwestern Univ, Chicago, IL, US
282 The DCIR Lectin, a New Receptor Involved in the
Transmission of HIV-1 from Dendritic Cells to CD4 + T Cells
Alexandra Lambert*, C Gilbert, and M Tremblay
Ctr Hosp of Laval Univ, Canada
283 The Evolutionary History of the CD209 (DC-SIGN) Family in
Human and Non-human Primates
Millan Ortiz*, K Zhang, and A Telenti
Inst of Microbio, Univ of Lausanne, Switzerland
284 Single Variant Transmission Predominates in HIV-1 Subtype
C Infection, with Multiple Variant Transmission Associated
with Increased Genital Inflammatory Cytokines
Carolyn Williamson* 1 , M Abrahams1 , F Treurnicht1 , C Seioghe1 ,
JA Passmore1 , N Wood1 , K Mlisana2 , B Hahn3 , S Abdool Karim2 , and the
CAPRISA002 Study and the Ctr for HIV/AIDS Vaccine Immunology
Consortium
1 2 Univ of Cape Town, South Africa; Univ of KwaZulu Natal, Durban,
South Africa; and 3Univ of Alabama at Birmingham, US
285 Transmission of Simian Immunodeficiency Virus by
Plasma Collected Prior to Detectable Viremia, and Relative
Infectivity of Ramp-up versus Chronic Stage Plasma
ZM Ma1 , M Piatak2 , L Fritts1 , D Lu1 , J Lifson2 , M Busch3 , and
Christopher Miller* 1
1California Natl Primate Res Ctr and Ctr for Comparative Med, Univ of
California, Davis, US; 2SAIC-Frederick and NCI-Frederick, MD, US; and
3Blood Systems Res Inst and Univ of California, San Francisco, US
286 Mucosally Transmissible R5 SHIV-2873Nip Encoding
env from a Child with Rapid Progression of HIV Clade C
Infection: A Tool for Vaccine Development
Siddappa Nagadenahalli* 1,2 , R Song1,2 , A Chenine1,2 , R Grisson1,2 ,
V Karmor1 , C Wood3 , G Bhat4 , R Amara5 , F Novembre5 , and R Ruprecht1,2 1 2 Dana-Farber Cancer Inst, Boston, MA, US; Harvard Med Sch, Boston,
MA, US; 3Nebraska Ctr for Virology and Sch of Biological Sci, Univ
of Nebraska, Lincoln, US; 4Univ Teaching Hosp, Lusaka, Zambia; and
5Yerkes Natl Primate Res Ctr, Emory Univ, Atlanta, GA, US
287 Uptake and Intracellular Behavior of HIV-1 in Human
Hepatoma Cells Leading to Virus Recycling and Transfer to
T Cells
Remi Fromentin*, R Lodge, M Tremblay, and D Leclerc
Infectious Disease Res Ctr, Quebec, Canada
288 Nuclear Receptor Ligands Inhibit HIV-1 cis- and transinfection
Timothy Hanley* and G Viglianti
Boston Univ Sch of Med, MA, US
289 Characterization of a Novel Mechanism of an Envelope
Glycoprotein-independent HIV-1 Capture and Transmission
Mediated by Mature Dendritic Cells
Nuria Izquierdo-Useros* 1 , I Erkizia-Jauregi1 , J Blanco1 , R Wiley2 ,
E Newton2 , J Archer2 , S Hatch2 , B Clotet1 , J Martinez-Picado1 , and
R Gummuluru2 1 2 Fndn irsiCaixa, Badalona, Spain and Boston Univ Sch of Med, MA, US
290 Cell-type and Envelope/Virion Dependence of Galectin-1mediated
Enhancement of HIV-1 Infection
Patrick Hong*, J Fulcher, and B Lee
David Geffen Sch of Med, Univ of California, Los Angeles, US
291 Mechanism of Human Defensins 5- and 6-mediated
Enhancement of HIV-1 Infectivity
A Rapista1 , W Lu2 , and Theresa Chang* 1
1 2 Mt Sinai Sch of Med, New York, NY, US and Univ of Maryland Biotech
Inst, Baltimore, US
28 15th Conference on Retroviruses and Opportunistic Infections
CROI 2008
292 Cell-to-cell HIV Transmission Targets CD45RO + CD4 T Cells
through LFA-1-dependent and -independent Mechanisms
Isabel Puigdomenech*, M Massanella, N Izquierdo-Useros, M Curriu,
R Ruiz-Hernandez, M Bofill, J Martinez-Picado, M Juan, B Clotet, and
J Blanco
Fndn irsiCaixa, Hosp Univ Germans Trias i Pujol, Spain
293 Impact of TLR2, 4, 5, 7, and 9 Stimulations on Dendritic Cell
HIV-1 Infection and Transfer to CD4 + T Cells
Sandra Thibault*, M Tardif, and M Tremblay
Infectious Diseases Res Ctr, Quebec, Canada
294 Phylogenetic Clustering of HIV-1 from Acutely Infected
Individuals Does Not Reflect a Higher per-Act Transmission
Probability
Erik Volz* and S Frost
Univ of California, San Diego AIDS Vaccine Res Ctr, US
b Monday, 1-4 pm; Hall D
Session 57–Poster Abstracts
Factors Impacting Disease Progression
295 Identification of an IL-7RA Risk Allele for Rapid Progression
to AIDS: Results of a Genomic IL-7/IL-7RA Study in the
GRIV Cohort
Sophie Limou* 1,2,3 , C Coulonges1 , H Do2 , A Vasilescu2 , T Labib1,3 , I Gut2 ,
JD Lelievre3 , Y Levy3 , and JF Zagury1,3 1 2 Conservatoire Natl des Arts et Metiers, Paris, France; CEA, Evry,
France; and 3Hosp Henri Mondor, INSERM U84, Creteil, France
296 CCL3L1 Variable Gene Copy Number Influence on the
Susceptibility to HIV-1/AIDS among Estonian Intravenous
Drug Users
Maarja Sadam*, K Huik, R Avi, T Karki, K Ruutel, and I Lutsar
Inst of Microbio, Univ of Tartu, Estonia
297 Interferon-γ Genotype (874T>A) Is Associated with CCR5
Expression in HIV + Patients
N Liptrott, B Chandler, S Khoo, D Back, and Andrew Owen*
Univ of Liverpool, UK
298 Use of a Dually Inducible Cell Line Reveals Distinct Patterns
of CD4 and CCR5 Usage among Laboratory and Primary
HIV-1 and SIV Strains
Samantha Johnston* 1 , M Lobritz2 , S Nguyen1 , C Garibay1 , B Ank1 ,
Y Bryson1 , E Arts2 , T Chou1 , and B Lee1 1 2 Univ of California, Los Angeles, US and Case Western Reserve Univ,
Cleveland, OH, US
299 Lack of Effect of Short Viremic Episodes in LPS Plasma
Levels in Chronically HIV-1-infected Subjects
Emmanouil Papasavvas* 1 , M Pistilli1 , A Hancock1 , G Reynolds1 ,
A Mackiewicz1 , C Gallo2 , J Kostman2,3 , K Mounzer2 , J Shull2 , and
L Montaner1 1 2 Wistar Inst, Philadelphia, PA, US; Philadelphia Field Initiating Group
for HIV Trials, PA, US; and 3Univ of Pennsylvania, Philadelphia, US
300 Reduction in the Absolute Number of Myeloid Dendritic
Cells and Plasmacytoid Dendritic Cells in HIV Infection
Correlates with Disease Progression
Meera Singh*, M Thakar, S Suregaonkar, M Ghate, and R Paranjape
Natl AIDS Res Inst, Pune, India
301 Role of TLR in HIV-1 Pathogenesis
Beda Brichacek*, A Biancotto, Y Kiselyeva, C Vanpouille, A Lisco,
J Grivel, and L Margolis
NIH, Bethesda, MD, US
302 Alternative pre-mRNA Splicing and Expression of ILT4 in
HIV-1 Chronic Infection
Danlei Mou*, M Lichterfeld, K Williams, D Kavanagh, H Duong,
B Walker, and X Yu
Partners AIDS Res Ctr, Massachusetts Gen Hosp, Boston, US
304 Micro-RNA of Host and HIV Origin Play a Major Role in the
Pathogenesis of HIV Infection and Its Control
Zvi Bentwich* 1,2 , E Meiri2 , A Levy2 , O Carmi1 , and Y Shemer1 1 2 Ben Gurion Univ Faculty of Hlth Sci, Beer Sheba, Israel and Rosetta
Genomics Inc, Rehovot, Israel
305 Chemokine Receptor Gene (CCR5 and CCR2) Haplotypes as
Risk Factors for HIV-1 Acquisition and Pathogenesis
Rakhi Malhotra* 1 , W Song1 , I Brill1 , D Chanda2 , J Mulenga2 , S Allen2,3 ,
E Hunter3 , J Tang1 , and R Kaslow1 1 2 Univ of Alabama at Birmingham, US; Rwanda-Zambia HIV-1 Res
Group, Lusaka; and 3Emory Univ, Atlanta, GA, US
306 Viroverse: A Research Database and Bioinformatics Analysis
Framework
Brandon Maust* 1 , W Deng1 , J Stoddard1 , Z Frazier2 , M Guerquin1 ,
G Learn1 , R Samudrala1 , R Bumgarner1 , and J Mullins1 1 2 Univ of Washington, Seattle, US and Univ of Southern California, Los
Angeles, US