Scientific Program Committee

CROI 2008 Session 55
b Tuesday, 1-4 pm; Hall D
Session 52–Poster Abstracts
Viral Fitness, Evolution and Recombination
253 Molecular Characterization of SIV in Wild Gorillas
gor
Jun Takehisa* 1 , M Kraus1 , Y Li1 , R Rudicell1 , B Keele1 , J Decker1 ,
E Bailes2 , P Sharp3 , M Peeters4 , and B Hahn1 1 2 3 Univ of Alabama at Birmingham, US; Univ of Nottingham, UK; Univ of
Edinburgh, Scotland; and 4Univ of Montpellier, France
254 Generation of in vivo Intersubtype BG Recombinants
of HIV-1 and Analysis of Intersubtype Breakpoints:
Comparison to BG Recombinants Generated in vivo
Mercedes Munoz-Nieto* 1 , L Perez-Alvarez1 , M Pinilla1 , Y Vega1 ,
E Delgado1 , V Garcia1 , M Sierra1 , M Thomson1 , C Miralles2 , and
R Najera1 1 2 Inst Salud Carlos III, Madrid, Spain and Hosp Xeral-Cies, Vigo,
Pontevedra, Spain
255 Immune-driven HIV-1 Recombination and Loss of Control
following Superinfection
Hendrik Streeck* 1 , B Li1 , A Poon2 , A Schneidewind1 , A Gladden1 ,
K Power1 , B Walker1 , M Altfeld1 , S Frost2 , and T Allen1 1Partners AIDS Res Ctr, Massachusetts Gen Hosp, Harvard Med Sch,
Boston, US and 2Univ of California, San Diego, US
256 Identifying the Important HIV-1 Recombination Breakpoints
John Archer* 1 , J Pinney1 , J Fan1 , E Simon-Loriere2 , E Arts3 ,
M Negroni2 , and D Robertson1 1 2 3 Univ of Manchester, UK; Pasteur Inst, Paris, France; and Case
Western Reserve Univ, Cleveland, OH, US
257 Molecular Characterization of Recombinant CCR5- and
CXCR4-utilizing HIV-1 Subtype C gp120
Katherine Michler*, W Stevens, M Papathanasopoulos, and
A Capovilla
Univ of the Witwatersrand Med Sch, Johannesburg, South Africa
258 A New Algorithm to Detect HIV-1 Intra-patient Recombinant
Sequences and Investigate the Role of Recombination in the
Emergence of CXCR4-using Viral Variants
M Salemi1 , R Gray1 , J Sleasman2 , S Koch1 , and Maureen Goodenow* 1
1 2 Univ of Florida, Gainsville, US and Univ of South Florida, St
Petersburg, US
259 Meta-evolutionary Analysis of Selection on HIV and Other
Viruses: Functional and Subtype Correlates
Sergei Kosakovsky Pond* 1 , C Woelk1 , A Poon1 , S Pillai2,3 , D Richman1,4 ,
and S Frost1 1 2 Univ of California, San Diego, US; Univ of California, San Francisco,
US; 3VAMC, San Francisco, CA, US; and 4VA San Diego Hlthcare
System, La Jolla, CA, US
260 Analysis of HIV-1 CA Residues under Positive Selective
Pressure
Angela Ciuffi*, K Zhang, M Munoz, R Martinez, and A Telenti
Inst of Microbio, Univ Hosp Ctr and Univ of Lausanne, Switzerland
261 Models of Neutralization and Sequence Variation in HIV-1
Selene Zarate* 1 , D Richman2,3 , J Overbaugh4,5 , and S Frost2 1 2 Univ Autonoma de la Ciudad de Mexico, Mexico City; Univ of
California, San Diego, US; 3VA Hlthcare System, San Diego, CA,
US; 4Fred Hutchinson Cancer Res Ctr, Seattle, WA, US; and 5Univ of
Washington, Seattle, US
262 Construction of Replication-competent Chimeric HIV-1
Reporter Viruses to Study Fitness Costs of Mutations in Non-
Clade B Contexts
Markus Bickel*, M Lewis, A Ali, and O Yang
Univ of California, Los Angeles, US
263 Differential Evolution of HIV-1 Reverse Transcriptase in
Treatment-naïve Female Genital Tract and Plasma
Uma Shanmugasundaram*, N Kumarasamy, K Murugavel, S Solomon,
and P Balakrishnan
YRGCARE, Voluntary Hlth Svcs, Chennai, India
b Wednesday, 1-4 pm; Hall D
Session 53–Poster Abstracts
HIV-1 Macrophage Studies
264 Visualization of HIV-1 Gag Trafficking to the Virological
Synapse in Living Infected Macrophages
K Gousset1 , S Ablan1 , L Coren2 , D Ott2 , and Eric Freed* 1
1 2 HIV Drug Resistance Prgm, NCI-Frederick, MD, US and SAIC-
Frederick and NCI-Frederick, MD, US
265 Galectin-1 Increases Transfer of HIV-1 from Macrophages to
CD4 + T Cells
Simon Mercier*, C St-Pierre, M Ouellet, M Tremblay, and S Sato
Laval Univ, Canada
266 Links between Cellular Factors Expressed during Monocyte
Differentiation and Productive HIV-1 Replication
Irena Kadiu* 1 , T Wang1 , M Ricardo-Dukelow2 , J Schlautman1 ,
P Ciborowski1 , and H Gendelman1 1 2 Univ of Nebraska Med Ctr, Omaha, US and Univ of Hawaii at Manoa,
Honolulu, US
267 HIV-1 Replication Is Enhanced by Macrophage Migration
Inhibitory Factor
Eduardo Regis* 1 , V Barreto-de-Souza1 , L Leng2 , R Bucala2 , M Bozza3 ,
and D Bou-Habib1 1 2 Oswaldo Cruz Inst, Fiocruz, Rio de Janeiro, Brazil; Yale Univ Sch of
Med, New Haven, CT, US; and 3Federal Univ of Rio de Janeiro, Brazil
268 Entry Co-receptor Use and Fusion Inhibitor T20 Sensitivity
of Dual-tropic R5X4 HIV-1 in Primary Macrophage
Infection
Yanjie Yi*, L Loftin, L Wang, S Ratcliffe, J Issacman-Beck, and
R Collman
Univ of Pennsylvania Sch of Med, Philadelphia, US
b Wednesday, 1-4 pm; Hall D
Session 54–Poster Abstracts
Co-infection: Virus/Virus Interactions
269 HIV Post-entry Inhibition by Non-structural GBV-C Proteins
Susan Jung*, R Muller, N Donhauser, B Fleckenstein, and H Reil
Univ Hosp, Erlangen, Germany
270 E2, a Novel and Potent HIV Entry Inhibitor Derived from the
Non-pathogenic GBV-C—Characterization of the Detailed
Mechanism
Kristin Hanel*, S Jung, B Fleckenstein, and H Reil
Univ Hosp Erlangen, Germany
271 Establishment of a Cord Blood Lymphocytes-based Cell
Culture System to Study GBV-C and HIV in vitro
Susan Jung*, S Weber, B Fleckenstein, and H Reil
Univ Hosp Erlangen, Germany
272 Interference between HSV-2 and HIV-1 in Co-infected
Human Lymphoid Tissue ex vivo
Christophe Vanpouille*, A Lisco, JC Grivel, A Biancotto,
B Brichacek, and L Margolis
NIH, Bethesda, MD, US
273 GBV-C Infection Is Associated with Less T Cell Activation
in Recently HIV-1-infected Subjects and Is Independent of
HIV-1 Viral Load
Maria Teresa Maidana Giret* 1 , T Silva1 , E Levi2 , H Tomiyama1 ,
K Bassichetto3 , A Nishiya4 , E Sabino4 , R Palacios1 , and E Kallas1 1 2 Federal Univ of Sao Paulo, Brazil; Inst of Tropical Diseases of Sao
Paulo, Brazil; 3Publ Hlth Dept of Sao Paulo, Brazil; and 4Blood Ctr of
Sao Paulo, Brazil
b Wednesday, 1-4 pm; Hall D
Session 55–Poster Abstracts
Viral Reservoirs
274 Phylodynamic Analysis of SIV Populations in Lymphoid
Tissues Reveals the Central Role of the Gut-associated
Lymphoid Tissue as a Reservoir during Suppressive ART
Thomas Ndolo* 1 , M Syvanen1 , J Pan1 , D Verhoeven1 , C Bedford2 ,
R Donovan2 , and S Dandekar1 1 2 Univ of California, Davis, US and California Dept of Hlth Svcs,
Richmond, US
275 HIV-1 Transmission from Infected Dendritic Cells and
Infection of Primary CD4 + T Lymphocytes in the Presence of
Entry Inhibitors Targeting Co-receptors or gp41
Jose Este* 1,2 , I Clotet1 , B Bosch1 , M Fernandez-Figueras2 , R Pena1 ,
M Bofill1 , and B Clotet1,2 1 2 Fndn irsiCaixa, Spain and Hosp Germans Trials i Pujol, Badalona, Spain
276 Different Activation Stimuli Induce Differential
Sequestration of HIV-1 in Human Dendritic Cells
Morgan Reuter*, H Yu, and D McDonald
Case Western Reserve Univ, Cleveland, OH, US
277 A Novel Model for the Establishment of HIV Latency
in Primary CD4 + Cells Demonstrates Epigenetic
Transcriptional Shutdown Due to Chromatin Restrictions
Mudit Tyagi* and J Karn
Case Western Reserve Univ Sch of Med, Cleveland, OH, US
278 CCL2 Enhances Permissiveness of Resting CD4 + T Cells to
Infection with X4-tropic HIV-1
Grant Campbell* and S Spector
Univ of California, San Diego, US
279 HIV-1 Tat Association with Cellular Promoters in Human
Immature Dendritic Cells
Nayoung Kim*, S Kukkonen, and A Aldovini
Children’s Hosp Boston, MA, US
Program 27
Poster Listings