Scientific Program Committee

Poster Litings
Session 49 CROI 2008
b Tuesday, 1-4 pm; Hall D
Session 49–Poster Abstracts
(see Session 40 on Wednesday for corresponding Poster Discussion)
New Insights into APOBEC Proteins
229 Deamination in 3D: Intra- and Intersegmental Transfer of
APOBEC3G Cytidine Deaminase
Roni Nowarski*, M Kotler, and E Britan
Hebrew Univ, Hadassah Med Sch, Jerusalem, Israel
230 APOBEC3G’s Cytoplasmic Localization Is Actively
Regulated but Not Required for HIV-1 Restriction
Mark Stenglein* and R Harris
Univ of Minnesota, Minneapolis, US
231 Enzymatically Active APOBEC3G Is Required for Efficient
Inhibition of HIV-1
E Miyagi, S Opi, H Takeuchi, M Khan, R Goila-Gaur, S Kao, and
Klaus Strebel*
NIH, Bethesda, MD, US
232 Distinct Packaging Mechanisms of Human Cytidine
Deaminase APOBEC3 Proteins into HIV-1 Virions
Lindi Tan*, T Wang, and X Yu
Johns Hopkins Univ, Baltimore, MD, US
233 Effect of Impaired Processivity of HIV-1 Reverse
Transcriptase on the G-to-A Mutation Rate Induced by
APOBEC-3G/-3F
Stefanie Knoepfel*, P Rauch, N Salisch, K Allers, P Huelsmann, and
K Metzner
Univ of Erlangen-Nuremberg, Germany
234 Protein Kinase A-mediated Phophorylation of APOBEC3G
Antagonizes Its Degradation by Vif
Kotaro Shirakawa*, A Takaori-Kondo, T Izumi, K Io, M Matsui, and
T Uchiyama
Kyoto Univ, Japan
b Tuesday, 1-4 pm; Hall D
Session 50–Poster Abstracts
Viral Replication Cycle: Molecular Studies
235 Dimerization of HIV-1 Spliced RNA in vitro
Lucile Sinck* 1 , D Richer1 , J Howard2 , M Alexander2 , D Purcell2 ,
R Marquet1 , and JC Paillart1 1 2 Inst of Molecular and Cellular Bio, CNRS, Strasbourg, France and Univ
of Melbourne, Parkville, Australia
236 Equine Infectious Anemia Virus Entry Occurs through
Clathrin-mediated Endocytosis
Melinda Brindley* and W Maury
Univ of Iowa, Iowa City, US
237 Changes to the HIV Long Terminal Repeat and to HIV
Integrase Differentially Affect HIV Integrase Assembly,
Activity, and the Binding of Strand Transfer Inhibitors
Ira Dicker* 1 , H Samanta1 , Z Li1 , Y Hong2 , Y Tian2 , J Banville1 ,
R Remillard1 , M Walker1 , D Langley1 , and M Krystal1 1 2 Bristol-Myers Squibb, Wallingford, CT, US and Bristol-Myers Squibb,
Princeton, NJ, US
238 Examination of HIV Integration Sites in Quiescent CD4
T Cells: Implications for Viral Mechanisms of Infection and
Gene Therapy
Dimitrios Vatakis*, S Kim, G Bristol, S Chow, and J Zack
David Geffen Sch of Med, Univ of California, Los Angeles, US
239 TRBP Directs HIV-1 mRNA to Polysomes for Efficient
Translation
S Campbell1 , F Fangsi Ke1 , J Waters1 , H Christensen1 , J Howard1 ,
M Alexander1 , A Gatignol2 , and Damian Purcell* 1
1 2 Univ of Melbourne, Parkville, Australia and McGill Univ, Lady Davis
Inst for Med Res, Montreal, Canada
240 The Effect of Episomal Overexpression of the HIV Wild Type
NC Protein on the Viral Particle Formation
Seonhee Kim*, S Jang, and J You
Catholic Univ of Korea, Sch of Med, Seoul, South Korea
26 15th Conference on Retroviruses and Opportunistic Infections
b Tuesday, 1-4 pm; Hall D
Session 51–Poster Abstracts
Viral Envelope: Tropism Co-receptor Studies
241 Selection of Replication-competent Strains of Simian
Immunodeficiency Virus Which Are Deficient in Sites for
Carbohydrate Attachment
Elizabeth Stansell* and R Desrosiers
New England Primate Res Ctr, Harvard Med Sch, Southborough, MA, US
242 A Single Residue in the HIV-1 Envelope V3 Domain
Modulates Exposure of the CD4 Binding Site
Rebecca Lynch* 1 , R Rong1 , W Honnen2 , J Mulenga3 , S Allen1 ,
J Blackwell1 , A Pinter2 , S Gnanakaran4 , and C Derdeyn1 1 2 Emory Univ, Atlanta, GA, US; Univ of Med and Dentistry of New
Jersey, New Jersey Med Sch, Newark, US; 3Zambia Blood Transfusion
Svc, Lusaka; and 4Los Alamos Natl Lab, NM, US
243 Functional Analysis of Intracellular Targeting Motifs within
HIV-1 Envelope Cytoplasmic Domain
Sushma Bhakta*, E Hunter, P Spearman, and N Tsurutani
Emory Univ, Atlanta, GA, US
244 Cross-reactive HIV-neutralizing Human Monoclonal
Antibody Recognizes Novel Conformational Epitope on gp41
and Lacks Reactivity against Self-antigens
Mei-Yun Zhang* 1,2 , B Vu1 , M Alam3 , R Ruprecht4 , G Quinnan5 , S Jiang6 ,
D Montefiori7 , C Broder5 , B Haynes3 , and D Dimitrov1 1 2 3 NCI-Frederick, MD, US; SAIC-Frederick MD, US; Human Vaccine
Inst, Durham, NC, US; 4Dana-Farber Cancer Inst, Boston, MA, US;
5 6 Uniformed Svcs Univ of the Hlth Sci, Bethesda, MD, US; Lindsley F
Kimball Res Inst, New York Blood Ctr, NY, US; and 7Duke Univ Med Ctr,
Durham, NC, US
245 Genotypic and Phenotypic Analysis of HIV-1 env Gene
Populations in Subjects with Dual or Mixed Entry
Phenotypes
Milloni Patel* 1,2 , G Schnell1,2 , M Pagan1,2 , and R Swantrom1,2 1 2 Univ of North Carolina at Chapel Hill, US and Ctr For AIDS Res, Univ
of North Carolina at Chapel Hill, US
246 Characterization of V2 and V3 Envelope Determinants and
their Correlation with Co-receptor Usage from a Cohort of
East London Patients Infected with HIV-1 Clade CRF02_AG
Ronald D’Amico* 1,2 , H Dreja2 , K Aubin3 , C Orkin4 , J Hand4 , C DeSouza4 ,
M Dittmar2 , and A McKnight2 1 2 London Sch of Hygiene and Tropical Med, UK; Barts and the London,
Queen Mary’s Univ, UK; 3Wohl Virion Ctr, Univ Coll London, UK; and
4St Bartholomew’s Hosp, London, UK
247 X4-tropic and Dualtropic Subtype C Biological Clones from
Syncytia Inducing Isolates
Elizabeth Johnston White*, B McColgan, S Kassaye, and D Katzenstein
Stanford Univ, Palo Alto, CA, US
248 Variation in HIV-1 R5 Macrophage-tropism Correlates
with Sensitivity to Reagents that Block Envelope: CD4
Interactions
P Peters1 , M Duenas-DeCamp1 , M Sullivan1 , R Brown2 ,
C Ankghuambom2 , K Luzuriaga1 , J Robinson3 , D Burton4 , J Ball2 , and
Paul Clapham* 1
1 2 Univ of Massachusetts Med Sch, Worcester, US; Univ of Nottingham,
UK; 3Tulane Univ Med Ctr, New Orleans, LA, US; and 4Scripps Res Inst,
La Jolla, CA, US
249 HIV-1 Viruses with Different Co-receptor Tropisms Are Not
Highly Compartmentalized in the Peripheral Blood
William Ince*, P Harrington, K Dang, G Schnell, J Eron, C Burch, and
R Swanstrom
Univ of North Carolina at Chapel Hill, US
250 Low CCR5 Expression Levels on Primary CD4 +
Lymphocytes Are a Major Obstacle to CCR5-mediated
Infection by R5X4 Viruses
Lamorris Loftin*, L Wang, Y Yi, J Isaacman-Beck, M Kienzle, and
R Collman
Univ of Pennsylvania, Philadelphia, US
251 The gp41 Transmembrane Subunit of HIV-1 Envelope
Influences CD4 Receptor-dependent Virus Entry
Jonathan Toma*, S Fransen, T Wrin, J Whitcomb, N Parkin,
C Petropoulos, and W Huang
Monogram Biosci, South San Francisco, CA, US
252 Susceptibility of Human Prostate to HIV-1 Infection
Anna le Tortorec1 , AP Satie1 , H Denis1 , L Havard2 , N Rioux-Leclercq2 ,
A Ruffault2 , B Jegou1 , and Nathalie Dejucq-Rainsford* 1
1 2 INSERM U625, Rennes, France and Ctr Hosp Univ Regional
Pontchaillou, Rennes, France