Scientific Program Committee

CROI 2008 Session 48
b Monday, 1-4 pm; Hall D
Session 46–Poster Abstracts
Cellular Co-factors
200 Visualization of the HIV Host Protein Interaction Network
Jonathan Dickerson* 1 , J Pinney1 , R Ptak2 , W Fu2 , B Sanders-Beer2,3 , and
D Robertson1 1 2 Univ of Manchester, UK; Southern Res Inst, Frederick, MD, US; and
3Bioqual, Inc, Rockville, MD, US
201 ADAM10: A Cellular Metalloprotease Required at or Just
Prior to HIV Integration
B Friedrich1 , J Murray2 , D Rubin3 , T Hodge2 , and William O’Brien* 1
1 2 Univ of Texas Med Branch, Galveston, US; Zirus, Buford, GA, US; and
3VA Tennessee Valley Hlthcare System and Vanderbilt Univ, Nashville, US
202 Transient Knockdown of the Von Hippel Lindau Binding
Protein 1 in HeLaP4 Cells Enhances HIV-1 Replication
Wannes Thys*, F Christ, J De Rijck, and Z Debyser
Katholieke Univ Leuven, Flanders, Belgium
203 Activator Protein 1 Synergizes with NF-κB to Activate Latent
HIV Provirus Transcription following T Cell Receptor
Activation
Joseph Hokello*, YK Kim, R Pearson, and J Karn
Case Western Reserve Univ, Cleveland, OH, US
204 Overexpression of NF90 or Its Mutants Together with Its
N-ter Region, Decrease Rev Export Activity and HIV-1
Replication
Claudia Patino* 1 , X Zapata1 , G St Laurent2 , A Kumar2 ,
D Hernandez-Verdun3 , and S Urcuqui-Inchima1 1 2 Univ de Antioquia, Colombia; George Washington Univ, Washington,
DC, US; and 3UMR 7592, Univ Paris VI and VII, France
205 The Receptor Tyrosine Kinase RON Represses HIV-1
Transcription by Targeting RNA Polymerase II Processivity
A Klatt1 , Z Zhang2 , P Kalantari1 , P Hankey1 , D Gilmour1 , and
Andrew Henderson* 3
1 2 Penn State Univ, Univ Park, US; Fox Chase Cancer Ctr, Philadelphia,
PA, US; and 3Boston Univ Sch of Med, MA, US
206 Dominant Negative Cyclin T1 Protein That Inhibits HIV
Transcription by Specifically Degrading Tat
Julie Jadlowsky* 1 , K Fujinaga1 , M Nojima1 , M Geyer2 , and
T Okamoto3 1 2 Case Western Reserve Univ, Cleveland, OH, US; Max-Planck-Inst for
Molecular Physiology, Dortmund, Germany; and 3Nagoya City Univ
Graduate Sch of Med Sci, Japan
207 PRMT6 Fine-tunes Localization Patterns of HIV-1 Proteins
Tat and Rev
Rita Schildknecht*, C Invernizzi, S Colby-Germinario, K Dahl,
J Martinez, B Spira, B Brenner, and M Wainberg
McGill Univ AIDS Ctr, Montreal, Canada
208 Roles for IST1 in VPS4 Regulation and HIV-1 Budding
Monika Bajorek*, E Morita, J Skalicky, M Babst, and W Sundquist
Univ of Utah, Salt Lake City, US
209 Functional Role of Alix in HIV-1 Replication
Ken Fujii*, U Munshi, S Ablan, and E Freed
NCI-Frederick, MD, US
210 Structure of Yeast Vps4p by Electron Microscopy and X-ray
Crystallography
Malgorzata Gonciarz* 1 , Z Yu2 , F Whitby1 , C Kieffer1 , G Jensen2 ,
W Sundquist1 , and C Hill1 1 2 Univ of Utah, Salt Lake City, US and California Inst of Tech, Pasadena,
US
211 Role of Kinases of the PIKK Family in Retroviral Replication
Y Yang, V Guen, and Lionel Berthoux*
Univ of Quebec, Trois-Rivieres, Canada
b Monday, 1-4 pm; Hall D
Session 47–Poster Abstracts
Cellular Restrictions
212 APOBEC3G Protein Expression in Blood Resting and
Activated CD4 + and CD8 + T Cells: Its Effect on Susceptibility
to HIV Infection and Progression
H Oliva1 , Montserrat Plana* 1 , A Lopez1 , J Martinez-Navio2 , R Franco2 ,
J Miro1 , F Garcia1 , J Gatell1 , N Navaratnam3 , and T Gallart1 1 2 Hosp Clin-IDIBAPS, Univ of Barcelona, Spain; Faculty of Bio, Univ of
Barcelona, Spain; and 3Med Res Council, Hammersmith Hosp, London,
UK
213 Target Cell APOBEC3C Can Induce Limited G-to-A
Mutation in HIV-1
K Bourara1 , T Liegler2 , and Robert Grant* 1,2
1Gladstone Inst of Virology and Immunology, San Francisco, CA, US and
2Univ of California, San Francisco, US
214 Determinants of HIV-1 Vif Regulation of APOBEC3 Proteins
Anna Maria Niewiadomska*, W Zhang, and XF Yu
Johns Hopkins Univ Bloomberg Sch of Publ Hlth, Baltimore, MD, US
215 The Anti-HIV-1 Potency of APOBEC1 Cytidine Deaminase
from Small Animal Species
Terumasa Ikeda* 1 , T Ohsugi 2 , T Kimura 1 , S Matsushita 3 , Y Maeda 1 ,
S Harada 1 , and A Koito 1
1 Grad Sch of Med Sci, Kumamoto Univ, Japan; 2 Ctr for Animal Resources
and Devt, Kumamoto Univ, Japan; and 3 Ctr for AIDS Res, Kumamoto
Univ, Japan
216 A Single Amino Acid of the HIV-2 Capsid Determines Its
Replication in the Presence of Cynomolgus Monkey and
Human TRIM5α
Haihan Song* 1 , E Nakayama1 , M Yokoyama2 , H Sato2 , J Levy3 , and
T Shioda1 1 2 Res Inst for Microbial Diseases, Osaka Univ, Japan; Natl Inst of
Infectious Diseases, Tokyo, Japan; and 3Univ of California, San
Francisco Sch of Med, Cancer Res Inst, US
217 Analysis of the Role of Cytoplasmic Bodies in TRIM5α
Restriction
Cindy Danielson*, E Campbell, M McRaven, and T Hope
Northwestern Univ, Chicago, IL, US
218 Using a Restriction-deficient Cell Line in the Search for
Cellular Proteins Important for TRIM5α Activity
Julie Berube*, A Bouchard, and L Berthoux
Univ of Quebec, Trois-Rivieres, Canada
b Monday, 1-4 pm; Hall D
Session 48–Poster Abstracts
Viral Accessory Genes
219 Co-variation Networks in HIV-1 Nef Sequences from
Phylogenetic and Mixtures Analysis
Art Poon* 1 , R Harrigan2 , and S Frost1 1 2 Univ of California, San Diego, US and BC Ctr for Excellence in HIV/
AIDS, Vancouver, Canada
220 Nef Proteins Derived from HIV-1 Subtypes C and F Fail to
Up-regulate Invariant Chain Cell Surface Expression
Gabriela Turk* 1 , P Benaroch2 , and H Salomon1 1Natl Reference Ctr for AIDS, Univ of Buenos Aires, Argentina and
2INSERM U653, Inst Curie, Paris, France
221 Nucleo-cytoplasmic Transport of Vpx Play a Critical Role in
HIV-2/SIV Replication in Non-dividing Cells
P Singhal1 , P Rajendra Kumar1 , and Sundarasamy Mahalingam* 1,2
1Ctr for DNA Fingerprinting and Diagnostics, Hyderabad, India and
2Indian Inst of Tech Madras, Chennai
222 CTIP2 Inhibits HIV-1 Vpr-induced Cell Cycle Arrest by
Repressing p21WAF1 Gene Expression
Stella Suzanne* 1 , T Cherrier1 , C Marban1 , B Samah2 , R Mukerjee3 ,
C Schwartz1 , S Zeichner4 , D Aunis1 , C Van Lint5 , and O Rohr1 1 2 INSERM U575, Univ Strasbourg 1, France; CEA, Fontenay aux Roses,
France; 3Ctr for Neurovirology and Cancer Bio, Coll of Sci and Tech,
Temple Univ, Philadelphia, PA, US; 4NCI, NIH, Bethesda, MD, US; and
5Inst for Molecular Bio and Med, Univ of Bruxelles, Gosselies, Belgium
223 Functional Properties of Naturally Occurring Truncated
Forms of HIV-1 Vif
Mohammad Khan* 1 , R Goila-Gaur1 , N Choudry2 , E Miyagi1 , S Kao1 ,
and K Strebel1 1 2 NIAID, NIH, Bethesda, MD, US and Univ of Maryland, US
224 HIV-1 Vif Causes G2 Cell Cycle Arrest via the p53 Pathway
Taisuke Izumi*, A Takaori-Kondo, K Shirakawa, K Io, M Matsui, and
T Uchiyama
Kyoto Univ, Japan
225 Genetic Patterns Associated with Functional Adaptation of
Nef to Down-regulate MHC-I and Evade CTL
Martha Lewis*, P Lee, A Rusmevichientong, L Hultin, and O Yang
David Geffen Sch of Med, Univ of California, Los Angeles, US
226 HIV-1-mediated Cell Cycle Arrest and Apoptosis in Human
CD4 + T Cells Is Independent of HIV-1 Env and Vpr
Alicja Dabrowska*, N Kim, and A Aldovini
Children’s Hosp Boston, MA, US
227 Importance of SIVmac239 Vpr Induced Cell Cycle Arrest for
Disease Progression
Sandra Mueller* 1,2 , B Scholz3 , S Weiler4 , N Stolte-Leeb5 ,
C Stahl-Hennig5 , B Fleckenstein3 , S Lang6 , and German Competence
Network on HIV/AIDS
1 2 Univ Hosp Erlangen, Germany; German Competence Network on
HIV/AIDS; 3Inst of Clinical and Molecular Virology, Univ Hosp
Erlangen, Germany; 4Univ of Erlangen, Germany; 5German Primate Ctr,
Goettingen; and 6Yale Univ Sch of Med, New Haven, CT,US
228 Vpr-mediated Inhibition of IL-12 and Disruption of
Upstream Signaling Receptors CD14, TLR4, and the
Glucocorticoid Receptor
Fiona Frappier* 1,2 , J Boucher1,2 , A O’Connor1,2 , and J Angel1,2 1 2 Univ of Ottawa, Canada and Ottawa Hlth Res Inst, Canada
Program 25
Poster Listings