Scientific Program Committee

Scientific Program Committee Scientific Program Committee

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CROI 2008 Session 43 c Wednesday, 2-3 pm; Room 302-304 CME Session 42–Poster Discussion (see Session 107 on Tuesday for corresponding Poster Abstracts) Maternal ART and Feeding Practices: Impact on Infant Outcomes Discussants: Elaine Abrams, Columbia Univ, Mailman Sch of Publ Hlth, New York, NY, US Francois Dabis, Univ Victor Segalen, Bordeaux, France 636 18-Month HIV-free Survival by Infant Feeding Practices in Children of HIV-infected Women in South Africa: The Vertical Transmission Study Nigel Rollins* 1 , R Becquet 2,3,4 , R Bland 2,5 , A Coutsoudis 1 , H Coovadia 6 , and ML Newell 2,7 1 Univ of KwaZulu Natal, Durban, South Africa; 2 Africa Ctr for Hlth and Population Studies, Univ of KwaZulu Natal, Somkhele, South Africa; 3 INSERM U593, Bordeaux, France; 4 Inst for Publ Hlth, Epi and Devt, Univ Victor Segalen, Bordeaux, France; 5 Univ of Glasgow, UK; 6 Ctr for HIV/AIDS Networking, Univ of KwaZulu Natal, Durban, South Africa; and 7 Ctr for Pediatric Epi and Biostatistics, Inst of Child Hlth, Univ Coll London, UK 637 Risk Factors for Mother-to-Child Transmission of HIV-1 from Breastfeeding in a Randomized Clinical Trial in Botswana: The Mashi Study Roger Shapiro* 1 , L Smeaton 2 , S Lockman 3 , I Thior 4 , R Rossenkhan 4 , C Wester 4 , L Stevens 4 , J Leidner 2 , J Makhema 4 , and M Essex 5 1 Beth Israel Deaconess Med Ctr, Boston, MA, US; 2 Harvard Sch of Publ Hlth, Ctr for Biostatistics in AIDS Res, Boston, MA, US; 3 Brigham and Women’s Hosp, Boston, MA, US; 4 Botswana Harvard Sch of Publ Hlth AIDS Initiative Partnership for HIV Res and Ed, Gaborone; and 5 Harvard Sch of Publ Hlth, Boston, MA, US 638 HIV-free Survival at 12 Months among Children Born to HIV-infected Women Receiving Antiretrovirals from 34 to 36 Weeks of Pregnancy Isabelle de Vincenzi* and the Kesho Bora Study Group WHO, Geneva, Switzerland 639 Decrease in HIV-1 Mother-to-Child Transmission in Women Receiving Postnatal HAART: 12-Month Follow-up Data M Marazzi 1 , L Palombi 2 , G Liotta 2 , P Germano 3 , N Abdul Majid 4 , I Zimba 4 , A Doro Altan 2 , G Bortolot 3 , and Karin Nielsen-Saines* 5 1 LUMSA Univ, Rome, Italy; 2 Univ of Tor Vergata, Rome, Italy; 3 DREAM Prgm, Community of St Egidio, Italy; 4 Benfica Hlth Ctr, Maputo, Mozambique; and 5 David Geffen Sch of Med, Univ of California, Los Angeles, US 640 Comparison of Adverse Fetal Outcomes in HIV-1-infected Antiretroviral- naïve Pregnant Women Who Have Received Combivir and Either Nevirapine or Nelfinavir for Prevention of Mother-to-Child Transmission Antenatally Rose Masaba* 1 , R Ndivo 1 , I Nyangau 1 , K Achola 1 , C Zeh 2 , M Thigpen 3 , P Weidle 3 , and T Thomas 2 1 Kenya Med Res Inst, Kisumu; 2 CDC Kenya, Kisumu; and 3 CDC, Atlanta, GA, US 641 Low Birth Weight with Nevirapine-based ART in Abidjan, Côte d’Ivoire: The ANRS Ditrame Plus Cohort and MTCT- Plus Initiative, 2001 to 2007 Didier Koumavi Ekouevi* 1,2 , B Tonwe-Gold 1,3 , R Becquet 1 , P Coffie 1,2 , P Toure 3 , V Leroy 1 , I Viho 2 , S Blanche 4 , F Dabis 1 , and E Abrams 5 1 INSERM U593, Inst for Publ Hlth, Epi and Devt, Bordeaux, France; 2 Natl Agency for AIDS Res Ditrame Plus Project, Abidjan, Côte d’Ivoire; 3 ACONDA, NGO, Abidjan, Côte d’Ivoire; 4 Hosp Necker, Paris France; and 5 MTCT-Plus Initiative, New York, NY, US e Wednesday, 4-6 pm; Ballroom A Session 43–Symposium CME Accessory Proteins and Intrinsic Resistance Conveners: Ned Landau, New York Univ, NY, US Aine McKnight, Barts and The London Sch of Med and Dentistry, UK 147 Vif and APOBEC: What We Know Xiao-Fang Yu Johns Hopkins Univ, Baltimore, MD, US 148 The Role of Vpu in Retrovirus Particle Release Paul Spearman Emory Univ Sch of Med, Atlanta, GA, US 149 Genetic Variation in TRIM5α and Related Genes Sara Sawyer* 1 , M Emerman 2 , and H Malik 2 1 Univ of Texas, Austin, US and 2 Fred Hutchinson Cancer Res Ctr, Seattle, WA, US 150 HIV Vpr Protein as a Mediator of Ubiquitylation Carlos de Noronha*, X Wen, L Casey, J Sharifi, and K Duus Albany Med Coll, NY, US Objectives: This session is directed to clinicians and scientists interested in HIV molecular biology, viral accessory genes, mechanisms of intracellular resistance to viruses and co-evolution of viruses and hosts. It is assumed that participants are familiar with basic cell and molecular biology, and the HIV genome and replication cycle. At the completion of the session participants will be knowledgeable about the HIV Vif, Vpr, and Vpu accessory proteins and about the APOBEC3 and Trim-5a host restriction factors. Program 23 Wednesday February 6 Sessions

CROI 2008 Session 43<br />

c Wednesday, 2-3 pm; Room 302-304<br />

CME<br />

Session 42–Poster Discussion<br />

(see Session 107 on Tuesday for corresponding Poster Abstracts)<br />

Maternal ART and Feeding Practices: Impact on<br />

Infant Outcomes<br />

Discussants:<br />

Elaine Abrams, Columbia Univ, Mailman Sch of Publ Hlth, New York, NY, US<br />

Francois Dabis, Univ Victor Segalen, Bordeaux, France<br />

636 18-Month HIV-free Survival by Infant Feeding Practices<br />

in Children of HIV-infected Women in South Africa: The<br />

Vertical Transmission Study<br />

Nigel Rollins* 1 , R Becquet 2,3,4 , R Bland 2,5 , A Coutsoudis 1 , H Coovadia 6 , and<br />

ML Newell 2,7<br />

1 Univ of KwaZulu Natal, Durban, South Africa; 2 Africa Ctr for Hlth and<br />

Population Studies, Univ of KwaZulu Natal, Somkhele, South Africa;<br />

3 INSERM U593, Bordeaux, France; 4 Inst for Publ Hlth, Epi and Devt,<br />

Univ Victor Segalen, Bordeaux, France; 5 Univ of Glasgow, UK; 6 Ctr for<br />

HIV/AIDS Networking, Univ of KwaZulu Natal, Durban, South Africa;<br />

and 7 Ctr for Pediatric Epi and Biostatistics, Inst of Child Hlth, Univ Coll<br />

London, UK<br />

637 Risk Factors for Mother-to-Child Transmission of HIV-1<br />

from Breastfeeding in a Randomized Clinical Trial in<br />

Botswana: The Mashi Study<br />

Roger Shapiro* 1 , L Smeaton 2 , S Lockman 3 , I Thior 4 , R Rossenkhan 4 ,<br />

C Wester 4 , L Stevens 4 , J Leidner 2 , J Makhema 4 , and M Essex 5<br />

1 Beth Israel Deaconess Med Ctr, Boston, MA, US; 2 Harvard Sch of Publ<br />

Hlth, Ctr for Biostatistics in AIDS Res, Boston, MA, US; 3 Brigham and<br />

Women’s Hosp, Boston, MA, US; 4 Botswana Harvard Sch of Publ Hlth<br />

AIDS Initiative Partnership for HIV Res and Ed, Gaborone; and 5 Harvard<br />

Sch of Publ Hlth, Boston, MA, US<br />

638 HIV-free Survival at 12 Months among Children Born to<br />

HIV-infected Women Receiving Antiretrovirals from 34 to<br />

36 Weeks of Pregnancy<br />

Isabelle de Vincenzi* and the Kesho Bora Study Group<br />

WHO, Geneva, Switzerland<br />

639 Decrease in HIV-1 Mother-to-Child Transmission in Women<br />

Receiving Postnatal HAART: 12-Month Follow-up Data<br />

M Marazzi 1 , L Palombi 2 , G Liotta 2 , P Germano 3 , N Abdul Majid 4 , I Zimba 4 ,<br />

A Doro Altan 2 , G Bortolot 3 , and Karin Nielsen-Saines* 5<br />

1 LUMSA Univ, Rome, Italy; 2 Univ of Tor Vergata, Rome, Italy; 3 DREAM<br />

Prgm, Community of St Egidio, Italy; 4 Benfica Hlth Ctr, Maputo,<br />

Mozambique; and 5 David Geffen Sch of Med, Univ of California, Los<br />

Angeles, US<br />

640 Comparison of Adverse Fetal Outcomes in HIV-1-infected<br />

Antiretroviral- naïve Pregnant Women Who Have<br />

Received Combivir and Either Nevirapine or Nelfinavir for<br />

Prevention of Mother-to-Child Transmission Antenatally<br />

Rose Masaba* 1 , R Ndivo 1 , I Nyangau 1 , K Achola 1 , C Zeh 2 , M Thigpen 3 ,<br />

P Weidle 3 , and T Thomas 2<br />

1 Kenya Med Res Inst, Kisumu; 2 CDC Kenya, Kisumu; and 3 CDC, Atlanta,<br />

GA, US<br />

641 Low Birth Weight with Nevirapine-based ART in Abidjan,<br />

Côte d’Ivoire: The ANRS Ditrame Plus Cohort and MTCT-<br />

Plus Initiative, 2001 to 2007<br />

Didier Koumavi Ekouevi* 1,2 , B Tonwe-Gold 1,3 , R Becquet 1 , P Coffie 1,2 ,<br />

P Toure 3 , V Leroy 1 , I Viho 2 , S Blanche 4 , F Dabis 1 , and E Abrams 5<br />

1 INSERM U593, Inst for Publ Hlth, Epi and Devt, Bordeaux, France;<br />

2 Natl Agency for AIDS Res Ditrame Plus Project, Abidjan, Côte d’Ivoire;<br />

3 ACONDA, NGO, Abidjan, Côte d’Ivoire; 4 Hosp Necker, Paris France;<br />

and 5 MTCT-Plus Initiative, New York, NY, US<br />

e Wednesday, 4-6 pm; Ballroom A<br />

Session 43–Symposium CME<br />

Accessory Proteins and Intrinsic Resistance<br />

Conveners:<br />

Ned Landau, New York Univ, NY, US<br />

Aine McKnight, Barts and The London Sch<br />

of Med and Dentistry, UK<br />

147<br />

Vif and APOBEC: What We Know<br />

Xiao-Fang Yu<br />

Johns Hopkins Univ, Baltimore, MD, US<br />

148<br />

The Role of Vpu in Retrovirus Particle Release<br />

Paul Spearman<br />

Emory Univ Sch of Med, Atlanta, GA, US<br />

149<br />

Genetic Variation in TRIM5α and Related Genes<br />

Sara Sawyer* 1 , M Emerman 2 , and H Malik 2<br />

1 Univ of Texas, Austin, US and 2 Fred Hutchinson Cancer Res Ctr,<br />

Seattle, WA, US<br />

150<br />

HIV Vpr Protein as a Mediator of Ubiquitylation<br />

Carlos de Noronha*, X Wen, L Casey, J Sharifi, and K Duus<br />

Albany Med Coll, NY, US<br />

Objectives: This session is directed to clinicians and scientists interested in<br />

HIV molecular biology, viral accessory genes, mechanisms of intracellular<br />

resistance to viruses and co-evolution of viruses and hosts. It is assumed that<br />

participants are familiar with basic cell and molecular biology, and the HIV<br />

genome and replication cycle. At the completion of the session participants<br />

will be knowledgeable about the HIV Vif, Vpr, and Vpu accessory proteins<br />

and about the APOBEC3 and Trim-5a host restriction factors.<br />

<strong>Program</strong> 23<br />

Wednesday<br />

February 6 Sessions

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