Scientific Program Committee

CROI 2008 Session 36
i Wednesday, 8:30-9 am; Auditorium
Session 34–Plenary CME
Advances in the Management of Treatmentexperienced
Patients: A 2 nd Wave of HAART
113
Sharon Walmsley
Univ of Toronto, Canada
Objectives: This session is directed to clinicians and scientists interested
in the current clinical management of persons living with HIV who have
developed resistant viruses. It is assumed that participants are familiar with
the major classes of antiretroviral agents and their mechanism of action. At the
completion of the session, participants will be knowledgeable about the goal
of maximal viral suppression in treatment-experienced patients, and the role
of new agents within existing classes and new targets for ART to help achieve
this goal.
j Wednesday, 9-9:30 am; Auditorium
Session 35–Plenary CME
New Insights into Retrovirus-Host-cell
Interactions
114
Paul Bieniasz
Aaron Diamond AIDS Res Ctr, The Rockefeller Univ, New
York, NY, US
Objectives: This session is directed to clinicians and scientists interested
in retrovirus-host interactions, in particular how host cells mount a defense
against retrovirus infection and how HIV-1 has evolved strategies to evade
or counteract these host defenses. It is assumed that participants are familiar
with the basic features of HIV-1 and its replication cycle. At the completion
of the session, participants will be knowledgeable about concepts associated
with intrinsic and innate cellular defenses that inhibit the HIV-1 replication
cycle, about a newly discovered cellular inhibitor called “tetherin” that blocks
the release of HIV-1 and other virus particles from infected cells, and how an
HIV-1 accessory gene antagonizes the function of this antiviral molecule.
k Wednesday, 10 am-12 noon; Room 302-304
CME
Session 36–Oral Abstracts
New Insights into Mechanisms of Viral
Pathogenicity
Moderators:
Satya Dandekar, Univ of California, Davis, US
Ivona Pandrea, Tulane Natl Primate Res Ctr, Covington, LA, US
10:00 115 Preferential Loss of Th17 CD4 T Cells in the
Gastrointestinal Tract of HIV-infected Individuals but
Not SIV-infected Sooty Mangabeys
Barbara Cervasi* 1 , J Brenchley2 , M Paiardini1 , S Gordon1 ,
A Asher2 , I Frank1 , J Else3 , D Douek2 , and G Silvestri1 1 2 Univ of Pennsylvania, Philadelphia, US; Vaccine Res Ctr, NIAID,
NIH, Bethesda, MD, US; and 3Yerkes Natl Primate Res Ctr, Emory
Univ, Atlanta, GA, US
10:15 116 Preferential Loss of Th17 T Cells at Mucosal Sites
Predicts AIDS Progression in Simian Immunodeficiency
Virus-infected Macaques
Valentina Cecchinato* 1 , C Trindade1 , JM Heraud1 , A Laurence2 ,
J Brenchley3 , E Tryniszewska1,4 , D Venzon1 , D Douek3 , J O’Shea2 ,
and G Franchini1 1 2 NCI, NIH, Bethesda, MD, US; Natl Inst of Arthritis and
Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, US;
3 4 NIAID, NIH, Bethesda, MD, US; and Med Univ of Bialystok,
Poland
10:30 117LB Primary SIV Infection Causes Rapid Loss of the Balance
between TH17 and T Regulatory Cell Populations in
Pathogenic Infection of Non-human Primates
David Favre* 1 , S Lederer2 , B Kanwar1 , ZM Ma3 , S Proll2 , Z Kasakow1 ,
C Miller3 , M Katze2 , and J McCune1 1 2 Univ of California, San Francisco, US; Univ of Washington,
Seattle, US; and 3Univ of California, Davis, US
10:45 118 SIVrcm, a Unique CCR2-tropic Virus, Selectively
Depletes Memory CD4 + T Cells in Pigtailed Macaques
Due to Rapid Co-receptor Expansion in vivo
Rajeev Gautam*, T Gaufin, I Butler, A Gautam, C Monjure,
M Barnes, M Pattison, P Marx, I Pandrea, and C Apetrei
Tulane Natl Primate Res Ctr, Covington, LA, US
11:00 119 Bacterial DNA Are Measurable in Plasma of HIVinfected
Patients and Are Diminished by ART
Wei Jiang* 1 , K Haley1 , S Sieg1 , M Lederman1 , A Aasher2 ,
D Douek2 , and J Brenchley2 1 2 Case Western Reserve Univ, Cleveland, OH, US and Vaccine Res
Ctr, NIAID, NIH, Bethesda, MD, US
11:15 120 Evidence for Persistent Viral Replication in Lymph
Node and GALT of ARV-treated Persons
Timothy Schacker* 1 , M Stevenson2 , J Brenchley3 , D Douek3 , and
A Haase1 1 2 Univ of Minnesota, Minneapolis, US; Univ of Massachuesetts,
Boston, US; and 3Vaccine Res Ctr, NIAID, NIH, Bethesda, MD, US
11:30 121 HIV-1 Rebound during ART Interruption Is Associated
with a Preferential Depletion of CD4 + T Cells from the
Gastrointestinal Tract
Saurabh Mehandru* 1,2 , M Poles1,3 , K Tenner-Racz4 , M LaRoche1 ,
K Rodriguez1 , T Evering1 , D Castor1 , A Lloyd1 , P Racz4 , and
M Markowitz1 1Aaron Diamond AIDS Res Ctr, The Rockefeller Univ, New York,
NY, US; 2Mt Sinai Sch of Med, New York, NY, US; 3New York Univ
Sch of Med, New York, US; and 4Bernhard Nocht Inst for Tropical
Med, Hamburg, Germany
11:45 122 Syndecan-3 Is a Dendritic Cell-specific Attachment
Receptor for HIV-1
L De Witte1 , M Bobardt2 , T Geijtenbeek1 , and Philippe Gallay* 2
1 2 VU Univ Med Ctr, Amsterdam, The Netherlands and Scripps Res
Inst, La Jolla, CA, US
Program 19
Wednesday
February 6 Sessions