Scientific Program Committee

Tuesday
February 5 Sessions
Session 29 CROI 2008
c Tuesday, 2-3 pm; Ballroom A
CME
Session 29–Poster Discussion
(see Session 165 on Wednesday for corresponding Poster Abstracts)
TB-associated Immune Reconstitution
Inflammatory Syndrome
Discussants:
Philippa Easterbrook, Infectious Disease Inst, Kampala, Uganda
Andrew Zolopa, Stanford Univ, Palo Alto, CA, US
1006 M. tuberculosis-specific T Cell Expansions and the
Pathogenesis of the HIV-TB-associated Immune
Reconstitution Inflammatory Syndrome
G Meintjes 1 , K Wilkinson 2 , K van Veen 1 , K Rebe 3 , D Pepper 3 ,
K Skolimowska 4 , M Rangaka 1 , R Seldon 1 , G Maartens 5 , and Robert Wilkinson* 1
1 Inst of Infectious Disease and Moleculr Med, Univ of Cape Town, South
Africa; 2 Natl Inst of Med Res, London, UK; 3 GF Jooste Hosp, Manenberg,
South Africa; 4 Imperial Coll London, UK; and 5 Univ of Cape Town, South
Africa
1007 Biomarkers of Immune Activation Are Predictors of HIV
Immune Reconstitution Inflammatory Syndrome
David Boulware* 1 , D Meya 2 , T Bergemann 1 , I Vlasova 1 , A Kambugu 2 ,
K McAdam 2 , E Janoff 3 , and P Bohjanen 1
1 Univ of Minnesota, Minneapolis, US; 2 Infectious Disease Inst, Makerere
Univ, Kampala, Uganda; and 3 Univ of Colorado Hlth Sci Ctr, Denver, US
1008 Immunologic Markers as Predictors of TB-associated
Immune Reconstitution Inflammatory Syndrome in HIV
and TB Co-infected Persons in Thailand
Hong Van Tieu* 1 , J Ananworanich 2 , A Avihingsanon 3,4 ,
W Apateerapong 2 , S Sirivichayakul 4,5 , S Klongugkara 6 , B Boonchokchai 2 ,
U Siangphoe 2 , S Hammer 1 , and W Manosuthi 6
1 Columbia Univ Coll of Physicians and Surgeons, New York, NY, US;
2 South East Asia Res Collaboration with Univ of Hawaii, Bangkok,
Thailand; 3 HIV Netherlands Australia Thailand Res Collaboration,
Bangkok; 4 Thai Red Cross AIDS Res Ctr, Bangkok; 5 Chulalongkorn
Univ, Bangkok, Thailand; and 6 Bamrasnaradura Infectious Diseases Inst,
Nonthaburi, Thailand
1009 High Rates of Drug-resistant TB among Patients with
Suspected TB Immune Reconstitution Inflammatory
Syndrome in South Africa
Kevin Rebe* 1,2 , G Meintjes 1,2 , M Rangaka 1 , D Pepper 2 , C Morroni 1 ,
G Maartens 1 , and R Wilkinson 1,2,3
1 Univ of Cape Town, South Africa; 2 GF Jooste Hosp, Manenberg, South
Africa; and 3 Imperial Coll, London, UK
16 15th Conference on Retroviruses and Opportunistic Infections
e Tuesday, 4-6 pm; Room 302-304
Session 30–Symposium CME
The Emerging Science of HIV Prevention in Women
Conveners:
Sharon Hillier, Univ of Pittsburgh, Magee-
Womens Res Inst, PA, US
Renee Ridzon, Bill and Melinda Gates Fndn,
Seattle, WA, US
93
Vaginal Flora, Co-infections, and Immune Cells
in the Genital Mucosa: Implications for HIV
Transmission
Rupert Kaul, Univ of Toronto, Canada
94
Impact of Hormonal Contraception on HIV
Acquisition, Cervico-Vaginal Viral Shedding, and
Disease Progression
Elizabeth Stringer
Univ of Alabama at Birmingham, Lusaka, Zambia
95
Genital Compartmentalization of Orally and
Topically Administered Antiretrovirals
Angela Kashuba
Univ of North Carolina at Chapel Hill, US
96
Microbicides: Rapid Evolution since 2000
Quarraisha Abdool Karim
Columbia Univ, NY, New York, US and Univ of Kwazulu Natal,
Durban, South Africa
Objectives: This session is directed to clinicians and scientists interested in
gender-specific issues related to genital distribution of antiretrovirals, immune
cells in the genital tract, the effect of female reproductive hormones on HIV,
and new biomedical HIV prevention options for women. It is assumed that
participants are familiar with risk factors for HIV transmission to women. At
the completion of the session, participants will be knowledgeable about the
effect of the vaginal ecology on immune cells in the female reproductive tract,
the influence of contraceptives on HIV susceptibility and disease progression,
the pharmacokinetics of orally and vaginally administered antiretrovirals in the
female genital tract, and ongoing research in topical microbicides.